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69 条记录 (耗时 0.019 秒)

    5-substituted benzophenone hydrazone compounds
    2.
    发明授权
    5-substituted benzophenone hydrazone compounds 失效
    5-取代苯并噻吩氢化合物

    公开(公告)号：US3857887A

    公开(公告)日：1974-12-31

    申请号：US37366073

    申请日：1973-06-26

    申请人： CHUGAI PHARMACEUTICAL CO LTD

    发明人： SHINDO M ,  KAKIMOTO M ,  NAGANO H

    IPC分类号： C07C109/16

    CPC分类号： C07C251/72

    摘要： 5-Substituted benzophenone hydrazones which possess an activity on the central nervous system are disclosed. The 5-substituted benzophenone hydrazones are prepared by the reaction of 5substituted benzophenones with hydrazine.

    摘要翻译： 公开了在中枢神经系统上具有活性的5-取代的二苯甲酮腙。 5-取代的二苯甲酮腙通过5-取代的二苯甲酮与肼的反应制备。

    Method for detecting cancer tussue by polarograph
    5.
    发明授权
    Method for detecting cancer tussue by polarograph 失效
    通过极地检测癌症治疗方法

    公开(公告)号：US3827948A

    公开(公告)日：1974-08-06

    申请号：US37743773

    申请日：1973-07-09

    申请人： CHUGAI PHARMACEUTICAL CO LTD

    发明人： HATA S

    IPC分类号： A61B10/00 ,  G01N27/48 ,  G01N33/483

    CPC分类号： G01N27/48

    摘要： A METHOD FOR DETECTING A CANCER TISSUE BY MEASURING A POLAROGRAPHIC WAVE IN THE RANGE OF FROM -1.0 TO -2.0 V. VS. S.C.E. ON AN EXTRACT OF A SUSPECTED TISSUE AT A PH VALUE OF FROM 5 TO 7 IN THE PRESENCE OFF AN ALKALINE METAL HALIDE TO DETERMINE THE PRESENCE OF A POLAROGRAPHIC WAVE AT AROUND -1.90 TO -1.95 V. VS. S.C.E. WHICH IS A CHARACTERISRIC OF THE CANCER TISSUE IS DISCLOSED

    Macrotetrolide miticide and insecticide
    7.
    发明授权
    Macrotetrolide miticide and insecticide 失效
    麦芽糖苷和杀虫剂

    公开(公告)号：US3777023A

    公开(公告)日：1973-12-04

    申请号：US3777023D

    申请日：1970-09-08

    申请人： CHUGAI PHARMACEUTICAL CO LTD

    发明人： TANAKA N ,  TOGASHI K ,  SAGAWA T ,  HIRANO S

    IPC分类号： A01N43/02 ,  A01P7/02 ,  A01P7/04 ,  C07D493/22 ,  A01N9/36

    CPC分类号： C07D493/22

    摘要： WHEREIN R1, R2, R3 AND R4 ARE SELECTED FROM THE GROUP CONSISTING OF METHYL AND ETHYL, WITH OR WITHOUT CONTAINING ONE OR MORE PESTICIDES SELECTED FROM THE GROUP CONSISTING OF ORGANO-CHLORIC PESTICIDES, CARBAMATE PESTICIDES AND ORGANO-PHOSPHORUS PESTICIDES IS DISCLOSED.

    (2,5-TETRAHYDROFURYLENE)-CH(-CH3)-CO-)

    -CH2-(2,5-TETRAHYDROFURYLENE)-CH(-CH3)-COO-CH(-R4)-CH2-

    CH(-R2)-CH2-(2,5-TETRAHYDROFURYLENE)-CH(-CH3)-COO-CH(-R3)

    O
    AN AGRICULTURAL COMPOSITION COMPRISING, AS ACTIVE INGREDIENTS, ONE OR MORE MACROTETROLIDE COMPOUNDS REPRESENTED BY THE FORMULA

    Hemostatic agent and the process of preparing same
    8.
    发明授权
    Hemostatic agent and the process of preparing same 失效
    化学药剂及其制备方法

    公开(公告)号：US3761586A

    公开(公告)日：1973-09-25

    申请号：US3761586D

    申请日：1971-03-02

    申请人： CHUGAI PHARMACEUTICAL CO LTD

    发明人： MATSUMOTO Y ,  KOYAMA K ,  TAKEDA Y

    IPC分类号： A61K35/58 ,  A61K17/00

    CPC分类号： A61K35/58

    摘要： The hemostatic agent of the present invention is obtained by the following process: An aqueous solution of Trimeresurus okinavensis venom is treated with almost the same volume of an organic solvent such as chloroform, ether and ethyl acetate to remove lipids, and the water layer is collected and dialysed against a distilled water. Dyalysate is passed through dextran gel column, said dextran gel having a molecular weight fractionation range of 1,000 to 50,000, to adsorb thereon and eluted with phosphate buffered solution (pH 7 - 8). The fraction having strong coagulating activity is collected in the recalcification test and passed through a column filled with a basic ion exchange resin to allow the active substance to adsorb thereon and eluted with ethyl acetate (pH about 7). The fraction having the highest blood coagulating activity is collected in the recalcification test, and lyophilised.

    摘要翻译： 本发明的止血剂通过以下方法得到：用几乎相同体积的有机溶剂如氯仿，乙醚和乙酸乙酯处理Trimeresurus okinavensis毒液的水溶液以除去脂质，并收集水层 并用蒸馏水透析。 透明质酸钠通过葡聚糖凝胶柱，所述葡聚糖凝胶具有1,000至50,000的分子量分级范围，以吸附并用磷酸盐缓冲溶液（pH7-8）洗脱。 在再钙化试验中收集具有强凝结活性的级分，并通过填充有碱性离子交换树脂的柱，使活性物质吸附在其上并用乙酸乙酯（pH约7）洗脱。 在再钙化试验中收集具有最高凝血活性的级分，并冻干。

    Cell wall lytic enzyme and process for the production thereof
    9.
    发明授权
    Cell wall lytic enzyme and process for the production thereof 失效
    细胞壁LYTIC ENZYME及其生产方法

    公开(公告)号：US3658650A

    公开(公告)日：1972-04-25

    申请号：US3658650D

    申请日：1970-03-06

    申请人： CHUGAI PHARMACEUTICAL CO LTD ,  HIROSHI IIZUKA

    发明人： OKAZAKI HIROSHI

    IPC分类号： C12N1/06 ,  C12N9/14 ,  C07G7/02

    CPC分类号： C12N9/14 ,  C12N1/06 ,  Y10S435/814 ,  Y10S435/816 ,  Y10S435/822

    摘要： A cell wall lytic enzyme which possesses an ability to lyse the cell wall of Chlorella, yeasts, etc. is produced by aerobically culturing a microorganism belonging to Genus Micropolyspora which produces a cell wall lytic enzyme in a medium containing assimilable carbon sources, assimilable nitrogen sources and essential inorganic salts and organic nutrients until a substantial amount of the enzyme is accumulated in said medium and isolating said enzyme from the medium, and, if desired, subjecting the thus obtained crude enzyme to the purification step of salting out or dialysis to obtain a purified enzyme solution and further subjecting the enzyme solution to freezedrying to obtain a powder preparation of said enzyme.

    摘要翻译： 具有裂解小球藻，酵母等的细胞壁的能力的细胞壁溶解酶是通过有氧培养属于微孢子虫属的微生物产生的，该微生物在含有可同化碳源的培养基中产生细胞壁裂解酶，可同化的氮源 和必需的无机盐和有机营养素，直到大量的酶积累在所述培养基中并从培养基中分离所述酶，并且如果需要，将由此获得的粗酶经过盐析或透析的纯化步骤获得 纯化的酶溶液，并进一步对酶溶液进行冷冻干燥，得到所述酶的粉末制剂。