公开(公告)号：US3786141A

公开(公告)日：1974-01-15

申请号：US3786141D

申请日：1971-09-30

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： TAKAGAKI Y ,  SUGAWARA Y ,  SUZUKI S ,  OGAWA H ,  YAMAMOTO A

IPC分类号： A61K9/14 ,  A61K9/19 ,  A61K35/74 ,  C12N1/06 ,  C12N1/20 ,  C12P1/04 ,  A01N15/00

CPC分类号： C12N1/20 ,  A61K35/744 ,  C12N1/06 ,  C12P1/04 ,  C12R1/46 ,  Y10S435/885

摘要： A WATER-INSOLUBLE ANTI-TUMOR ACTIVE SUBSTANCE IS PRE PARED FROM THE LIVING CELLS OF HEMOLYTIC STREPTOCOCCI BY LYSING THE CELLS OF HEMOLYTIC STREPTOCOCCI WITH A LYTIC ENZYME AND COLLECTING A WATER-INSOLUBLE FRACTION WHICH CORRESPONDS TO A PROTOPLAST MEMBRANE FRACTION OF THE CELLS. THE PREPARATION OF THE ANTI-TUMOR SUBSTANCE IS FAR SUPERIOR IN THE ANTI-TUMOR ACTIVITY TO THAT OF WATER-SOLUBLE FRACTION AND HAS LESS INFLAMMATION-, FEVER- AND PAINCAUSING PROPERTIES THAN ANY ONES OF PRIOR ART.

公开(公告)号：US3729554A

公开(公告)日：1973-04-24

申请号：US3729554D

申请日：1971-03-15

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： SUZUKI S ,  OKAZAKI H ,  SUGAWARA Y ,  OGAWA H ,  MATSUNO T ,  WADA S ,  YAMAMOTO A ,  NOTO T ,  TAKAGAKI Y

IPC分类号： A61K35/74 ,  C12K3/00

CPC分类号： A61K35/744 ,  Y10S435/885

摘要： BY ADDING CEPHALOSPORIN C OR CYCLOSERINE TO A LIVING CELL SUSPENSION OF HEMOLYTIC STREPTOCCI HAVING ANTITUMOR ACTIVITY IN A SUSPENSION MEDIUM TO TREAT THE CELLS WITH THE ANTIBIOTIC, IT IS POSSIBLE TO ELIMINATE TOXICITY WITH INCREASING ANTI-TUMOR ACTIVITY TO MAKE THEM USEFUL ANTITUMOR PREPARATIONS.