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    Well Plate
    1.
    发明申请
    Well Plate 有权
    井板

    公开(公告)号：US20090046832A1

    公开(公告)日：2009-02-19

    申请号：US12192762

    申请日：2008-08-15

    申请人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Rebecca L.E. Miller

    发明人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Rebecca L.E. Miller

    IPC分类号： G01N23/223

    CPC分类号： G01N23/2202 ,  G01N23/2204 ,  G01N23/223 ,  G01N2223/074 ,  G01N2223/076 ,  G01N2223/309 ,  G01N2223/64 ,  G03B42/02

    摘要： The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry.

    摘要翻译： 本发明包括通过X射线荧光光谱法制备用于测量的样品的装置。 该装置包括具有穿过板的一个或多个孔的板。 孔被板的一侧的薄膜覆盖。 在膜覆盖孔的一个维度上，孔小于500微米。 这部电影对于x射线是半透明的。 本发明还包括通过X射线荧光光谱法制备用于测量的样品的装置。 该装置包括具有穿过板的一个或多个孔的板。 孔通过可拆卸的盖子覆盖在板的一侧上，该盖子形成对板的防水密封。 该盖基本上不含锇，钇，铱，磷，锆，铂，金，铌，汞，铊，钼，硫，铅，铋，锝，钌，氯，铑，钯，氩， 和钍。 这些孔在一个尺寸上小于约500微米，其中盖覆盖孔。 本发明还包括通过X射线荧光光谱法制备用于测量的样品的方法。 该方法包括提供小于10微摩尔溶质的溶液和约2微升至约2毫升的体积。 使用x射线荧光光谱法浓缩溶液并进行分析。

    Well plate
    5.
    发明授权
    Well plate 有权
    井盘

    公开(公告)号：US08238515B2

    公开(公告)日：2012-08-07

    申请号：US12192762

    申请日：2008-08-15

    申请人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Rebecca L. E. Miller

    发明人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Rebecca L. E. Miller

    IPC分类号： G01N23/223

    CPC分类号： G01N23/2202 ,  G01N23/2204 ,  G01N23/223 ,  G01N2223/074 ,  G01N2223/076 ,  G01N2223/309 ,  G01N2223/64 ,  G03B42/02

    摘要： The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry.

    摘要翻译： 本发明包括通过X射线荧光光谱法制备用于测量的样品的装置。 该装置包括具有穿过板的一个或多个孔的板。 孔被板的一侧的薄膜覆盖。 在膜覆盖孔的一个维度上，孔小于500微米。 这部电影对于x射线是半透明的。 本发明还包括通过X射线荧光光谱法制备用于测量的样品的装置。 该装置包括具有穿过板的一个或多个孔的板。 孔通过可拆卸的盖子覆盖在板的一侧上，该盖子形成对板的防水密封。 该盖基本上不含锇，钇，铱，磷，锆，铂，金，铌，汞，铊，钼，硫，铅，铋，锝，钌，氯，铑，钯，氩， 和钍。 这些孔在一个尺寸上小于约500微米，其中盖覆盖孔。 本发明还包括通过X射线荧光光谱法制备用于测量的样品的方法。 该方法包括提供小于10微摩尔溶质的溶液和约2微升至约2毫升的体积。 使用x射线荧光光谱法浓缩溶液并进行分析。

    Methods for measuring analyte transport across barriers using x-ray fluorescence
    8.
    发明授权
    Methods for measuring analyte transport across barriers using x-ray fluorescence 有权
    使用X射线荧光测量跨屏障的分析物传输的方法

    公开(公告)号：US09063154B2

    公开(公告)日：2015-06-23

    申请号：US13871697

    申请日：2013-04-26

    申请人： XRpro Sciences, Inc.

    发明人： Benjamin P. Warner ,  Rebecca L. E. Miller ,  Lori J. Peterson ,  Jennifer A. Berger ,  Eva R. Birnbaum

    IPC分类号： C12Q1/02 ,  G01N21/76 ,  G01N23/223 ,  G01N33/50 ,  G01N33/68

    CPC分类号： G01N33/6872 ,  G01N23/2076 ,  G01N23/223 ,  G01N33/502 ,  G01N2223/076

    摘要： The present invention comprises a method for measuring the transport of analytes through a cell. The method comprises the steps of providing one or more cells containing at least 10 picograms of an analyte within a volume defined by the area of an x-ray excitation beam and a depth of live times the 1/e attenuation, depth for at least one characteristic x-ray signal of the analyte as attenuated by water. The method further comprises the step of removing at least a of portion of the analyte from the cells. The method also comprises the steps of exciting at least a portion of the analyte that has been removed from the cells with an x-ray beam; and using an x-ray detector to measure x-ray fluorescence.

    摘要翻译： 本发明包括用于测量分析物通过细胞的转运的方法。 该方法包括以下步骤：提供一个或多个细胞，其在由x射线激发束的区域限定的体积内的至少10皮克分析物和1 / e衰减深度的至少一个 分析物的特征X射线信号被水减弱。 该方法还包括从细胞中去除至少一部分分析物的步骤。 该方法还包括以x射线束激发已经从细胞中除去的分析物的至少一部分的步骤; 并使用X射线检测器来测量x射线荧光。

    Well Plate
    9.
    发明申请
    Well Plate 有权

    公开(公告)号：US20150023467A1

    公开(公告)日：2015-01-22

    申请号：US14508322

    申请日：2014-10-07

    申请人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Rebecca L.E. Miller

    发明人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Rebecca L.E. Miller

    IPC分类号： G01N23/223 ,  G01N23/22

    CPC分类号： G01N23/2202 ,  G01N23/2204 ,  G01N23/223 ,  G01N2223/074 ,  G01N2223/076 ,  G01N2223/309 ,  G01N2223/64 ,  G03B42/02

    摘要： The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry.

    Method and Apparatus for Measuring Protein Post-Translational Modification
    10.
    发明申请
    Method and Apparatus for Measuring Protein Post-Translational Modification 审中-公开

    公开(公告)号：US20090087919A1

    公开(公告)日：2009-04-02

    申请号：US12239459

    申请日：2008-09-26

    申请人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Lori J. Peterson-Court ,  Michael N. Harris ,  Rebecca L.E. Miller

    发明人： Eva R. Birnbaum ,  Benjamin P. Warner ,  Sharon M. Baldwin ,  Jennifer A. Berger ,  Lori J. Peterson-Court ,  Michael N. Harris ,  Rebecca L.E. Miller

    IPC分类号： G01N33/00 ,  G01N21/64

    CPC分类号： C12Q1/485 ,  C12Q1/37 ,  G01N21/75 ,  G01N23/223 ,  G01N33/20 ,  G01N33/6842 ,  G01N2223/076 ,  G01N2333/91215 ,  G01N2333/96441 ,  Y10T436/17 ,  Y10T436/200833

    摘要： The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.