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公开(公告)号：US20230149387A1
公开(公告)日：2023-05-18
申请号：US17917853
申请日：2021-04-08
IPC分类号： A61K31/472 , A61K31/4439 , A61K33/22 , A61K47/18 , A61K47/26 , A61K47/10 , A61K31/519 , A61K47/02 , A61K9/00 , A61P31/14 , A61P27/02 , A61P11/00 , A61K31/4725
CPC分类号： A61K31/472 , A61K31/4439 , A61K33/22 , A61K47/183 , A61K47/26 , A61K47/186 , A61K47/10 , A61K31/519 , A61K47/02 , A61K9/008 , A61K9/0048 , A61P31/14 , A61P27/02 , A61P11/00 , A61K31/4725
摘要： Described herein are compounds, combinations of compounds, compositions, formulations, and methods of treating viruses, viral load, and manifestations of viral infections.
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公开(公告)号：US20220331156A1
公开(公告)日：2022-10-20
申请号：US17714333
申请日：2022-04-06
发明人： Leo Anthony Trevino , Cheng Lin , Tyler Pegoraro , Stuart Williams , Thomas Shepard , Peter Andrew Smith , Matthew Charles Walker , Andrew John Corson , Thomas Ralph Blackburn, III , Stephen James Couse
IPC分类号： A61F9/00
摘要： Implant delivery devices, methods of device assembly and methods of using those devices are presented where the delivery device uses an automatic implant delivery mechanism that eliminates variability in pusher wire speeds by providing a needle assembly having one or more implants positioned within a proximal end of a needle cannula, a dampener assembly and a shuttle assembly located within a housing along with the activation member which holds the shuttle assembly in cocked or pre-tensioned state. A lock can be engaged with the activation member to prevent premature firing or triggering of the device.
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公开(公告)号：US20210363141A1
公开(公告)日：2021-11-25
申请号：US17243272
申请日：2021-04-28
IPC分类号： C07D417/12 , C07C237/20 , C07D401/12 , C07D409/12 , C07D217/00 , C07C237/42 , C07D333/40 , C07D217/04 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D413/12 , C07D333/38
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
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公开(公告)号：US20210300874A1
公开(公告)日：2021-09-30
申请号：US17339828
申请日：2021-06-04
IPC分类号： C07D217/22 , A61K47/28
摘要： Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.
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公开(公告)号：US11116776B2
公开(公告)日：2021-09-14
申请号：US16712624
申请日：2019-12-12
发明人： Stuart Williams , Sanjib Kumar Das , Tomas Navratil , Melissa Sandahl , Janet Tully , Rozemarijn Verhoeven
IPC分类号： A61K31/58 , A61K9/00 , A61K9/08 , A61K9/10 , A61K9/16 , A61K31/573 , A61K47/26 , A61K47/36 , A61F9/00 , A61M31/00
摘要： The disclosure teaches precisely engineered biodegradable drug delivery systems and methods of making and utilizing such systems. In aspects, the biodegradable drug delivery systems taught herein comprise intravitreal ocular implants suitable for delivery of corticosteroids to the posterior segment of a human eye. The intravitreal ocular implants described herein have a desired extended drug release profile suitable for treating inflammation of the human eye.
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公开(公告)号：US11028081B2
公开(公告)日：2021-06-08
申请号：US16730058
申请日：2019-12-30
IPC分类号： C07D417/12 , C07C237/20 , C07D401/12 , C07D409/12 , C07D217/00 , C07C237/42 , C07D333/40 , C07D217/04 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D413/12 , C07D333/38
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
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公开(公告)号：US10849656B2
公开(公告)日：2020-12-01
申请号：US15695810
申请日：2017-09-05
发明人： Tomas Navratil , Jessie Delgado , Michael Hunter
摘要： Embodiments described herein relate generally to medical implant delivery apparatuses and methods. In some embodiments, an apparatus comprises a first cap, a needle hub at least partially disposed within the first cap, a pusher wire and a pusher wire connector disposed within the needle hub, a needle and a second cap. The first cap includes a proximal end, a distal end, and a longitudinal axis. The needle includes a first, beveled end configured to receive an implant, and a second end disposed within a hub pocket of the needle hub. The second cap is connected to the needle hub and disposed at a proximal end of the first cap. The pusher wire, the pusher wire connector, and the needle are substantially aligned with one another along the longitudinal axis of the first cap. In some embodiments, the pusher wire is sized to be received in the bore of the needle.
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公开(公告)号：US09849122B2
公开(公告)日：2017-12-26
申请号：US15142461
申请日：2016-04-29
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , C07D409/12 , A61K31/557 , A61K31/5575 , A61K31/559 , A61K9/00 , A61K9/08 , A61K47/48
CPC分类号： A61K31/472 , A61K9/0048 , A61K9/08 , A61K31/4725 , A61K31/557 , A61K31/5575 , A61K31/559 , A61K47/54 , A61K47/55 , C07D217/22 , C07D409/12 , A61K2300/00
摘要： Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.
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公开(公告)号：US09840468B1
公开(公告)日：2017-12-12
申请号：US15395068
申请日：2016-12-30
IPC分类号： C07D217/02 , C07D217/22
CPC分类号： C07D217/02 , C07C201/12 , C07D217/22 , C07C205/57
摘要： Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.
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公开(公告)号：US09365518B2
公开(公告)日：2016-06-14
申请号：US14583439
申请日：2014-12-26
IPC分类号： C07D217/02 , C07D215/38 , C07D401/02 , A61K31/47 , C07D217/04 , C07D401/12
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
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