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公开(公告)号：US20230323305A1
公开(公告)日：2023-10-12
申请号：US18296158
申请日：2023-04-05
申请人： 3-D Matrix, Ltd. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL1) , L’ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYON (CPE Lyon)
CPC分类号： C12N5/0656 , B33Y70/00 , C12N2513/00
摘要： A bioink comprises a cell solution comprising living cells and a cell culture medium, and a self-assembling peptide solution comprising a self-assembling peptide. The bioink is formed by mixing and extruding the cell solution and the self-assembling peptide solution together, and the bioink can be continuously extruded from the mixer after mixing. Useful methods of making bioinks and are also disclosed.
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公开(公告)号：US20230190864A1
公开(公告)日：2023-06-22
申请号：US18109096
申请日：2023-02-13
申请人： 3-D Matrix, Ltd.
发明人： Lisa Spirio , Zen Chu
IPC分类号： A61K38/10 , A61K9/00 , A61K38/00 , A61K45/06 , A61L27/54 , A61L27/22 , A61K47/42 , A61K45/00
CPC分类号： A61K38/10 , A61K9/0019 , A61K38/00 , A61K45/06 , A61L27/54 , A61L27/227 , A61K47/42 , A61K45/00 , A61L2400/12 , A61L2400/06
摘要： A plurality of amphiphilic peptide chains having alternating hydrophilic and hydrophobic amino acids, wherein the peptide contains at least 8 amino acids, are complementary and structurally compatible, and self-assemble into a beta-sheet macroscopic scaffold wherein peptide at least about 75% of the chains have the same sequence.
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公开(公告)号：US20220001047A1
公开(公告)日：2022-01-06
申请号：US17372424
申请日：2021-07-10
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Karl Patrick Gilbert
摘要： Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
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公开(公告)号：US20210170073A1
公开(公告)日：2021-06-10
申请号：US16865734
申请日：2020-05-04
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Marc Rioult , Keiji Nagano , Karl Patrick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
摘要： Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
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公开(公告)号：US10961274B2
公开(公告)日：2021-03-30
申请号：US16062801
申请日：2016-12-15
申请人： 3-D Matrix, Ltd.
发明人： Eun Seok Gil , Marc Rioult , Keiji Nagano , Karl Patrick Gilbert , Toshiro Kiyofuji , Yuya Hasegawa
摘要： Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.
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公开(公告)号：US10369237B2
公开(公告)日：2019-08-06
申请号：US15122749
申请日：2015-03-10
申请人： 3-D MATRIX, LTD.
发明人： Eun Seok Gil , Karl Patrick Gilbert
摘要： Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
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公开(公告)号：US10245299B2
公开(公告)日：2019-04-02
申请号：US15124636
申请日：2015-03-10
申请人： 3-D MATRIX, LTD.
发明人： Manav Mehta , Hisashi Tsukada , Eun Seok Gil , Karl Gilbert , Satoru Kobayashi
摘要： Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
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8.发明申请METHOD AND COMPOSITION FOR THE TREATMENT, PREVENTION, AND DIAGNOSIS OF CANCER CONTAINING OR DERIVED FROM CANCER STEM CELLS 审中-公开用于治疗，预防和诊断包含或从癌症干细胞衍生的癌症的方法和组合公开(公告)号：US20130236891A1
公开(公告)日：2013-09-12
申请号：US13817763
申请日：2011-01-24
申请人： Takahiro Ochiya
发明人： Takahiro Ochiya
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/7105 , C12N2310/14 , C12N2310/3513 , C12N2310/531 , C12N2320/32 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Y204/99018 , G01N33/574 , G01N33/57415 , G01N2333/91097
摘要： The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.
摘要翻译： 本发明提供了用于治疗，预防和诊断含有或衍生自癌症干细胞的癌症的方法和组合物。
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公开(公告)号：US12006085B2
公开(公告)日：2024-06-11
申请号：US17832612
申请日：2022-06-04
申请人： 3-D Matrix, Ltd.
发明人： Masahiro Nohara , Yuya Hasegawa
IPC分类号： C07K1/34 , B65B3/00 , B65B55/04 , B65B55/12 , B65B63/00 , C07K1/36 , C07K7/08 , A61K38/00 , C07K5/103 , C07K5/11
CPC分类号： B65B55/12 , B65B3/003 , B65B55/04 , B65B63/00 , C07K1/34 , C07K1/36 , C07K7/08 , A61K38/00 , C07K5/101 , C07K5/1019
摘要： The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US11801281B2
公开(公告)日：2023-10-31
申请号：US17568026
申请日：2022-01-04
申请人： 3-D Matrix, Ltd.
发明人： Kentaro Takamura , Satoshi Gojo , Satoru Kobayashi
IPC分类号： A61K38/10 , C07K7/08 , A61K38/16 , A61L31/14 , A61L31/04 , A61K31/7004 , A61K31/7016 , A61K38/08 , C07K7/06
CPC分类号： A61K38/10 , A61K31/7004 , A61K31/7016 , A61K38/08 , A61K38/16 , A61L31/047 , A61L31/148 , C07K7/06 , C07K7/08 , A61L2400/04 , A61L2430/36
摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.
The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.
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