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![4-Nitro-2-[(4'-methoxy)-phenoxy]-methanesulfonanilide derivatives and their pharmaceutical use](/abs-image/US/2007/03/15/US20070060544A1/abs.jpg.150x150.jpg)
1.发明申请4-Nitro-2-[(4'-methoxy)-phenoxy]-methanesulfonanilide derivatives and their pharmaceutical use 审中-公开4-硝基-2 - [（4'-甲氧基） - 苯氧基] - 甲磺酰苯胺衍生物及其药物用途公开(公告)号：US20070060544A1
公开(公告)日：2007-03-15
申请号：US10541058
申请日：2003-12-30
Applicant: Zhuangrong Sun , Zuze Wu , Zhongdong Tang , Alquan Liu
Inventor： Zhuangrong Sun , Zuze Wu , Zhongdong Tang , Alquan Liu
IPC: A61K31/724 , A61K31/198 , A61K31/18 , C08B30/18
CPC classification number: A61K9/0014 , A61K9/0019 , A61K31/18 , A61K47/32 , A61K47/40 , C07C311/08
Abstract: 4-nitro-2-[4′-methoxy)-phenoxy]-methane-sulfonanilide or the pharmaceutical acceptable salts or solvates or hydrates thereof are provided. Also provided is their mixture with povidone, phospholipids or cyclodextrin, as well as their pharmaceutical uses, particularly the use as a non-steroidal anti-inflammatory, analgetic agent.
Abstract translation: 提供4-硝基-2- [4'-甲氧基） - 苯氧基] - 甲烷 - 磺酰苯胺或其药学上可接受的盐或溶剂合物或水合物。 还提供了它们与聚维酮，磷脂或环糊精的混合物，以及它们的药物用途，特别是用作非甾体抗炎镇痛剂的用途。
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2.发明授权Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes 有权顺式1,2-取代的二苯乙烯衍生物及其在制备用于治疗和/或预防糖尿病的药物中的用途公开(公告)号：US08039513B2
公开(公告)日：2011-10-18
申请号：US11658239
申请日：2005-07-20
Applicant: Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
Inventor： Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
IPC: A01N33/00 , A01N37/18 , A61K31/13 , A61K31/16 , A61K31/165 , C07C43/02 , C07C233/00 , C07C235/00 , C07C237/00
CPC classification number: C07C235/34 , C07B2200/09 , C07C39/23 , C07C43/23 , C07C59/64 , C07C69/017 , C07C69/54 , C07C235/36 , C07D295/185 , C07D307/14 , C07H15/203
Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
Abstract translation: 本发明涉及顺式1,2-取代的二苯乙烯衍生物或其药学上可接受的盐，葡糖苷或溶剂化物，包含该化合物的药物组合物和所述化合物用于制备用于治疗和/或预防糖尿病的药物的用途 或改善糖尿病并发症。
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3.发明申请Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes 有权顺式1,2-取代的二苯乙烯衍生物及其在制备用于治疗和/或预防糖尿病的药物中的用途公开(公告)号：US20090076114A1
公开(公告)日：2009-03-19
申请号：US11658239
申请日：2005-07-20
Applicant: Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
Inventor： Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
IPC: A61K31/085 , C07C43/23 , A61K31/192 , A61K31/341 , A61P3/10 , A61K31/40 , A61K31/165 , C07C59/64
CPC classification number: C07C235/34 , C07B2200/09 , C07C39/23 , C07C43/23 , C07C59/64 , C07C69/017 , C07C69/54 , C07C235/36 , C07D295/185 , C07D307/14 , C07H15/203
Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
Abstract translation: 本发明涉及顺式1,2-取代的二苯乙烯衍生物或其药学上可接受的盐，葡糖苷或溶剂化物，包含该化合物的药物组合物和所述化合物用于制备用于治疗和/或预防糖尿病的药物的用途 或改善糖尿病并发症。
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4.发明申请公开(公告)号：US20060127389A1
公开(公告)日：2006-06-15
申请号：US10526682
申请日：2003-09-03
Applicant: Bingxing Shi , Zuze Wu , Aiping Yu , Chunna Dong
Inventor： Bingxing Shi , Zuze Wu , Aiping Yu , Chunna Dong
CPC classification number: C07K14/47 , A61K38/00 , C07K14/31 , C07K14/815 , C07K19/00 , C07K2319/00 , C07K2319/50 , C12N9/6459 , C12N15/62 , C12Y304/21069
Abstract: This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
Abstract translation: 本申请涉及融合蛋白，其由溶血栓蛋白，抗凝血蛋白和接头肽组成。 特别地，融合蛋白由抗凝血蛋白和具有纤溶酶原激活活性的蛋白质分子组成，其中所述两种蛋白质通过接头肽连接在一起，可通过凝血因子识别和切割。 本申请还涉及所述融合蛋白的医学用途，以及使用凝血因子可以识别血液凝固蛋白和抗凝蛋白的接头肽。
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公开(公告)号：US20100234291A2
公开(公告)日：2010-09-16
申请号：US12519309
申请日：2009-12-22
Applicant: Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
Inventor： Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
CPC classification number: C12N15/62 , A61K38/00 , C07K14/46 , C07K14/4711 , C07K14/8128 , C07K14/815 , C07K2319/00 , C12N9/6432 , C12N9/6443 , C12Y304/21006 , C12Y304/21027
Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
Abstract translation: 提供了一种抗凝血融合蛋白，其包含由XIa因子和因子Xa或凝血酶和因子Xa可识别和切割的寡肽。 还提供了抗凝血融合蛋白的制备方法及其药物用途。
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Patent Agency Ranking
公开(公告)号：US20100144628A1
公开(公告)日：2010-06-10
申请号：US12521135
申请日：2007-12-21
Applicant: Zuze Wu , Bingxing Shi , Chunping Cui , Shaojun Du , Danli Wu
Inventor： Zuze Wu , Bingxing Shi , Chunping Cui , Shaojun Du , Danli Wu
IPC: A61K38/17 , C07K14/435 , C07H21/00 , A61K31/7052 , A61P1/16 , A61P35/00
CPC classification number: C07K14/4753 , A61K31/7088 , A61K38/00
Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.
Abstract translation: 提供了一种促肝细胞生成素PCn（HPPCn）及其同源蛋白，可以在体外促进肝细胞增殖，促进体内肝脏再生，抑制肿瘤细胞的生长，促进肿瘤细胞的凋亡。 肝细胞生成素PCn（HPPCn）及其同源蛋白可用于治疗急性和慢性肝损伤或治疗肝纤维化。
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7.发明授权Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof 有权具有溶栓和抗凝活性的双功能融合蛋白及其用途公开(公告)号：US08212003B2
公开(公告)日：2012-07-03
申请号：US10526682
申请日：2003-09-03
Applicant: Bingxing Shi , Zuze Wu , Aiping Yu , Chunna Dong
Inventor： Bingxing Shi , Zuze Wu , Aiping Yu , Chunna Dong
CPC classification number: C07K14/47 , A61K38/00 , C07K14/31 , C07K14/815 , C07K19/00 , C07K2319/00 , C07K2319/50 , C12N9/6459 , C12N15/62 , C12Y304/21069
Abstract: This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
Abstract translation: 本申请涉及融合蛋白，其由溶血栓蛋白，抗凝血蛋白和接头肽组成。 特别地，融合蛋白由抗凝血蛋白和具有纤溶酶原激活活性的蛋白质分子组成，其中所述两种蛋白质通过接头肽连接在一起，可通过凝血因子识别和切割。 本申请还涉及所述融合蛋白的医学用途，以及使用凝血因子可以识别血液凝固蛋白和抗凝蛋白的接头肽。
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8.发明授权Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases 有权二苯乙烯化合物在制备用于预防和治疗糖尿病或逆转录病毒相关疾病的药物中的用途公开(公告)号：US07384920B2
公开(公告)日：2008-06-10
申请号：US10484821
申请日：2001-07-26
Applicant: Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
Inventor： Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
CPC classification number: A61K31/7034 , A61K31/015 , A61K31/05 , A61K31/085
Abstract: This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus associated diseases.
Abstract translation: 本发明涉及1,2-二苯乙烯衍生物或其药学上可接受的盐的新用途，特别是在制备用于预防和治疗糖尿病或逆转录病毒相关疾病的药物中。
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9.发明申请Use of stilbene compounds in preparing medicaments for treating or preventing diabetes and diseases associated with retrovirus 有权二苯乙烯化合物在制备用于治疗或预防糖尿病和与逆转录病毒有关的疾病的药物中的应用公开(公告)号：US20050020511A1
公开(公告)日：2005-01-27
申请号：US10484821
申请日：2001-07-26
Applicant: Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
Inventor： Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
IPC: A61K31/00 , A61K31/015 , A61K31/05 , A61K31/085 , A61K31/7034 , A61P3/10 , A61P31/12 , A61K31/704
CPC classification number: A61K31/7034 , A61K31/015 , A61K31/05 , A61K31/085
Abstract: This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus associated diseases.
Abstract translation: 本发明涉及1,2-二苯乙烯衍生物或其药学上可接受的盐的新用途，特别是在制备用于预防和治疗糖尿病或逆转录病毒相关疾病的药物中。
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公开(公告)号：US08361795B2
公开(公告)日：2013-01-29
申请号：US12521135
申请日：2007-12-21
Applicant: Zuze Wu , Bingxing Shi , Chunping Cui , Shaojun Du , Danli Wu
Inventor： Zuze Wu , Bingxing Shi , Chunping Cui , Shaojun Du , Danli Wu
IPC: C12N5/06 , C12N5/08 , A61K38/16 , A61K31/70 , C07K14/475
CPC classification number: C07K14/4753 , A61K31/7088 , A61K38/00
Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.
Abstract translation: 提供了一种促肝细胞生成素PCn（HPPCn）及其同源蛋白，可以在体外促进肝细胞增殖，促进体内肝脏再生，抑制肿瘤细胞的生长，促进肿瘤细胞的凋亡。 肝细胞生成素PCn（HPPCn）及其同源蛋白可用于治疗急性和慢性肝损伤或治疗肝纤维化。
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