公开(公告)号：US08361795B2

公开(公告)日：2013-01-29

申请号：US12521135

申请日：2007-12-21

Applicant: Zuze Wu ,  Bingxing Shi ,  Chunping Cui ,  Shaojun Du ,  Danli Wu

Inventor： Zuze Wu ,  Bingxing Shi ,  Chunping Cui ,  Shaojun Du ,  Danli Wu

IPC: C12N5/06 ,  C12N5/08 ,  A61K38/16 ,  A61K31/70 ,  C07K14/475

CPC classification number: C07K14/4753 ,  A61K31/7088 ,  A61K38/00

Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.

Abstract translation: 提供了一种促肝细胞生成素PCn（HPPCn）及其同源蛋白，可以在体外促进肝细胞增殖，促进体内肝脏再生，抑制肿瘤细胞的生长，促进肿瘤细胞的凋亡。 肝细胞生成素PCn（HPPCn）及其同源蛋白可用于治疗急性和慢性肝损伤或治疗肝纤维化。

公开(公告)号：US20100144628A1

公开(公告)日：2010-06-10

申请号：US12521135

申请日：2007-12-21

Applicant: Zuze Wu ,  Bingxing Shi ,  Chunping Cui ,  Shaojun Du ,  Danli Wu

Inventor： Zuze Wu ,  Bingxing Shi ,  Chunping Cui ,  Shaojun Du ,  Danli Wu

IPC: A61K38/17 ,  C07K14/435 ,  C07H21/00 ,  A61K31/7052 ,  A61P1/16 ,  A61P35/00

CPC classification number: C07K14/4753 ,  A61K31/7088 ,  A61K38/00

Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.

Abstract translation: 提供了一种促肝细胞生成素PCn（HPPCn）及其同源蛋白，可以在体外促进肝细胞增殖，促进体内肝脏再生，抑制肿瘤细胞的生长，促进肿瘤细胞的凋亡。 肝细胞生成素PCn（HPPCn）及其同源蛋白可用于治疗急性和慢性肝损伤或治疗肝纤维化。