知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.02 秒)

    Truss semi-submersible offshore floating structure
    1.
    发明申请
    Truss semi-submersible offshore floating structure 审中-公开
    桁架半潜式离岸浮式结构

    公开(公告)号：US20070166109A1

    公开(公告)日：2007-07-19

    申请号：US11332707

    申请日：2006-01-13

    申请人： Yun Ding ,  William Soester

    发明人： Yun Ding ,  William Soester

    IPC分类号： E02D5/54

    CPC分类号： B63B39/06 ,  B63B1/04 ,  B63B1/107 ,  B63B9/065 ,  B63B11/00 ,  B63B35/4413 ,  B63B2001/044 ,  B63B2009/067 ,  B63B2039/067 ,  B63B2207/02

    摘要： A semi-submersible structure. The hull includes four columns that are supported by two pontoons. The columns support the topsides and the topsides structural framing serves as horizontal framing between the columns. A truss frame is attached to the columns. The truss frame preferably includes heave plates. The truss frame extends downward below the pontoons a sufficient distance in the water such that it minimizes motions caused by environmental forces. The hull section and the truss space frame are constructed separately and assembled together at the offshore site where the structure is used for drilling and/or production.

    摘要翻译： 半潜式结构。 船体包括由两个浮筒支撑的四列。 支柱支撑顶部，顶部结构框架用作柱之间的水平框架。 桁架架连接到柱子上。 桁架框架优选地包括升沉板。 桁架架在水下向下延伸到水下足够的距离，使其最小化由环境力引起的运动。 船体部分和桁架空间框架分别构造在组合在一起的结构用于钻井和/或生产的海上场地。

    HEAVE PLATE ON FLOATING OFFSHORE STRUCTURE
    2.
    发明申请
    HEAVE PLATE ON FLOATING OFFSHORE STRUCTURE 审中-公开
    浮标式海洋结构

    公开(公告)号：US20100260554A1

    公开(公告)日：2010-10-14

    申请号：US12420903

    申请日：2009-04-09

    申请人： Yun Ding ,  William Lawrence Soester ,  Cheng-Yo Chen

    发明人： Yun Ding ,  William Lawrence Soester ,  Cheng-Yo Chen

    IPC分类号： E02D29/00

    CPC分类号： B63B35/4413

    摘要： A floating offshore structure having a buoyant hull with an open truss frame having heave plates vertically spaced along the truss frame. One or more of the heave plates include a skirt plate that is attached around the outer perimeter of the heave plate and increases the effectiveness of the heave plate at trapping water mass between the heave plates for reducing heave motions of the floating offshore structure. A skirt plate is attached to one or more heave plates at essentially a right angle to the heave plate. The skirt plate may extend beyond the upper and lower surfaces of the heave plate or be positioned so as to be flush with the one surface of the heave plate and extend only beyond the opposite surface of the heave plate.

    摘要翻译： 浮式海上结构具有浮力船体，开放的桁架架具有沿着桁架框架垂直间隔开的升降板。 一个或多个升沉板包括围绕升沉板的外周边附接的裙板，并且增加了在沉积板之间捕获水质量的升沉板的有效性，以减少浮动海上结构的起伏运动。 裙板以与升沉板基本上成直角的方式附接到一个或多个升沉板。 裙板可以延伸超过升沉板的上表面和下表面，或者定位成与升沉板的一个表面齐平并且仅延伸到升沉板的相对表面。

    sEH inhibitors and their use
    3.
    发明授权
    sEH inhibitors and their use 有权
    sEH抑制剂及其用途

    公开(公告)号：US08212032B2

    公开(公告)日：2012-07-03

    申请号：US12757089

    申请日：2010-04-09

    申请人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, Jr.

    发明人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, Jr.

    IPC分类号： C07D251/50 ,  A61K31/53 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P11/00 ,  A61P13/12

    CPC分类号： C07D241/46 ,  C07D251/18 ,  C07D251/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/04

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to (Cis)-N-{[4-cyano-2-(trifluoromethyl)phenyl]methyl}-3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxamide; or a pharmaceutically acceptable salt thereof, and N-{[4-cyano-2-(trifluoromethyl)phenyl]methyl}-3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxamide; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。 具体地，本发明涉及（C 1）-N - {[4-氰基-2-（三氟甲基）苯基]甲基} -3 - {[4-甲基-6-（甲基氨基）-1,3,5-三嗪 -2-基]氨基}环己烷甲酰胺; 或其药学上可接受的盐和N - {[4-氰基-2-（三氟甲基）苯基]甲基} -3 - {[4-甲基-6-（甲基氨基）-1,3,5-三嗪-2-基 - 吡啶-2-基]氨基}环己烷甲酰胺; 或其药学上可接受的盐。

    NOVEL sEH INHIBITORS AND THEIR USE
    4.
    发明申请
    NOVEL sEH INHIBITORS AND THEIR USE 审中-公开
    新型抑制剂及其用途

    公开(公告)号：US20100210655A1

    公开(公告)日：2010-08-19

    申请号：US12682068

    申请日：2008-10-10

    申请人： Yun Ding ,  Allyn T. Londregan ,  Joseph Paul Marino, JR.

    发明人： Yun Ding ,  Allyn T. Londregan ,  Joseph Paul Marino, JR.

    IPC分类号： A61K31/53 ,  C07D403/14 ,  C07D403/04 ,  A61P9/00 ,  A61P1/16 ,  A61P11/06 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D403/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R5a, R6a, A, B, Y, I, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

    摘要翻译： 本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。 具体地，本发明涉及式I化合物：其中R1，R2，R5a，R6a，A，B，Y，I和m定义如下，及其药学上可接受的盐。 本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。

    Truss semi-submersible offshore floating structure
    5.
    发明授权
    Truss semi-submersible offshore floating structure 失效
    桁架半潜式离岸浮式结构

    公开(公告)号：US07871222B2

    公开(公告)日：2011-01-18

    申请号：US12037341

    申请日：2008-02-26

    申请人： Yun Ding ,  William Lawrence Soester

    发明人： Yun Ding ,  William Lawrence Soester

    IPC分类号： E21B17/08

    CPC分类号： B63B39/06 ,  B63B1/04 ,  B63B1/107 ,  B63B9/065 ,  B63B11/00 ,  B63B35/4413 ,  B63B2001/044 ,  B63B2009/067 ,  B63B2039/067 ,  B63B2207/02

    摘要： A semi-submersible structure. The hull includes four columns that are supported by two pontoons. The columns support the topsides and the topsides structural framing serves as horizontal framing between the columns. A truss frame is attached to the columns. The truss frame preferably includes heave plates. The truss frame extends downward below the pontoons a sufficient distance in the water such that it minimizes motions caused by environmental forces. The hull section and the truss space frame are constructed separately and assembled together at the offshore site where the structure is used for drilling and/or production.

    摘要翻译： 半潜式结构。 船体包括由两个浮筒支撑的四列。 支柱支撑顶部，顶部结构框架用作柱之间的水平框架。 桁架架连接到柱子上。 桁架框架优选地包括升沉板。 桁架架在水下向下延伸到水下足够的距离，使其最小化由环境力引起的运动。 船体部分和桁架空间框架分别构造在组合在一起的结构用于钻井和/或生产的海上场地。

    NOVEL sEH INHIBITORS AND THEIR USE
    6.
    发明申请
    NOVEL sEH INHIBITORS AND THEIR USE 有权
    新型抑制剂及其用途

    公开(公告)号：US20100210656A1

    公开(公告)日：2010-08-19

    申请号：US12682073

    申请日：2008-10-10

    申请人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, JR.

    发明人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, JR.

    IPC分类号： A61K31/53 ,  C07D401/04 ,  C07D251/18 ,  C07D409/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D251/52 ,  A61P9/10 ,  A61P9/00 ,  A61P9/04 ,  A61P11/06 ,  A61P11/00 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D241/46 ,  C07D251/18 ,  C07D251/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/04

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

    摘要翻译： 本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。 具体地，本发明涉及式I化合物：其中R1，R2，R4，R5，R6，A，B，Y，Z，n和m定义如下，及其药学上可接受的盐。 本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。

    sEH inhibitors and their use
    7.
    发明授权
    sEH inhibitors and their use 有权
    sEH抑制剂及其用途

    公开(公告)号：US08008483B2

    公开(公告)日：2011-08-30

    申请号：US12682077

    申请日：2008-10-10

    申请人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, Jr.

    发明人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, Jr.

    IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  A61K31/53 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P11/00 ,  A61P13/12 ,  A61P1/16

    CPC分类号： C07D401/04 ,  C07D251/54 ,  C07D401/14 ,  C07D403/04 ,  C07D409/14

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a A, B, Y, x, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

    摘要翻译： 本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。 具体地，本发明涉及式I化合物及其药学上可接受的盐，其中R1，R2，R3，R5a，R6aA，B，Y，x和m定义如下。 本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。

    NOVEL sEH INHIBITORS AND THEIR USE
    8.
    发明申请
    NOVEL sEH INHIBITORS AND THEIR USE 有权
    新型抑制剂及其用途

    公开(公告)号：US20100210628A1

    公开(公告)日：2010-08-19

    申请号：US12682077

    申请日：2008-10-10

    申请人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, JR.

    发明人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, JR.

    IPC分类号： A61K31/55 ,  C07D403/04 ,  A61K31/53 ,  C07D403/14 ,  C07D413/14 ,  A61K31/5377 ,  C07D401/14 ,  A61P3/10 ,  A61P3/04 ,  A61P1/16 ,  A61P9/00 ,  A61P11/06

    CPC分类号： C07D401/04 ,  C07D251/54 ,  C07D401/14 ,  C07D403/04 ,  C07D409/14

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a A, B, Y, x, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

    摘要翻译： 本发明涉及新型sEH抑制剂及其用于治疗由sEH酶介导的疾病的用途。 具体地，本发明涉及式I化合物及其药学上可接受的盐，其中R1，R2，R3，R5a，R6aA，B，Y，x和m定义如下。 本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。

    sEH inhibitors and their use
    9.
    发明授权
    sEH inhibitors and their use 有权
    sEH抑制剂及其用途

    公开(公告)号：US08173805B2

    公开(公告)日：2012-05-08

    申请号：US12682073

    申请日：2008-10-10

    申请人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, Jr.

    发明人： Yun Ding ,  Reema K. Thalji ,  Joseph P. Marino, Jr.

    IPC分类号： C07D251/54 ,  C07D403/12 ,  C07D403/14 ,  A61K31/53 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P11/00 ,  A61P13/12

    CPC分类号： C07D241/46 ,  C07D251/18 ,  C07D251/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/04

    摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

    摘要翻译： 本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。 具体地，本发明涉及式I化合物：其中R1，R2，R4，R5，R6，A，B，Y，Z，n和m定义如下，及其药学上可接受的盐。 本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。