公开(公告)号：US20100112699A1

公开(公告)日：2010-05-06

申请号：US12344931

申请日：2008-12-29

Applicant: Yu-Der LEE ,  Kuo-Yung Chang ,  Li-Wei Cheng

Inventor： Yu-Der LEE ,  Kuo-Yung Chang ,  Li-Wei Cheng

IPC: C12N5/06 ,  C07K14/00 ,  C08L89/00

CPC classification number: C08B37/0069 ,  C08L5/08

Abstract: The invention discloses a porous composite biomaterial comprising of poly(γ-glutamic acid)-g-chondroitin sulfate (γ-PGA-g-CS) copolymer and poly(ε-caprolactone). The composite biomaterial provides a three-dimensional microenvironment for using as a scaffold for tissue engineering and for supporting the attachment and proliferation of cells. The invention also discloses a method of producing a porous composite biomaterial.

Abstract translation: 本发明公开了一种由聚（γ-谷氨酸）-g-硫酸软骨素（γ-PGA-g-CS）共聚物和聚（ε-己内酯）组成的多孔复合生物材料。 复合生物材料提供了三维微环境，用于组织工程的支架和支持细胞的附着和增殖。 本发明还公开了一种生产多孔复合生物材料的方法。

公开(公告)号：US20120122219A1

公开(公告)日：2012-05-17

申请号：US13356322

申请日：2012-01-23

Applicant: Yu-Der LEE ,  Kuo-Yung Chang ,  Li-Wei Cheng

Inventor： Yu-Der LEE ,  Kuo-Yung Chang ,  Li-Wei Cheng

IPC: C12N5/077

CPC classification number: C08B37/0069 ,  C08L5/08

Abstract: The invention discloses a porous composite biomaterial comprising of poly(γ-glutamic acid)-g-chondroitin sulfate (γ-PGA-g-CS) copolymer and poly(ε-caprolactone). The composite biomaterial provides a three-dimensional microenviroment for using as a scaffold for tissue engineering and for supporting the attachment and proliferation of cells. The invention also discloses a method of producing a porous composite biomaterial.

Abstract translation: 本发明公开了一种由聚（γ-谷氨酸）-g-硫酸软骨素（γ-PGA-g-CS）共聚物和聚（ε-己内酯）组成的多孔复合生物材料。 复合生物材料提供了三维微环境，用于组织工程的支架和支持细胞的附着和增殖。 本发明还公开了一种生产多孔复合生物材料的方法。

公开(公告)号：US20100203150A1

公开(公告)日：2010-08-12

申请号：US12320843

申请日：2009-02-06

Applicant: Yu-Der Lee ,  Kuo-Yung Chang ,  Chia-Chun Lin

Inventor： Yu-Der Lee ,  Kuo-Yung Chang ,  Chia-Chun Lin

IPC: A61K9/14 ,  A61K31/7072

CPC classification number: A61K9/1075 ,  A61K31/00

Abstract: The present invention discloses a comb-like amphiphilic copolymer comprising a hydrophilic segment and a hydrophobic segment. It also discloses a novel fabrication method for synthesizing said amphiphilic copolymers. A novel initiator comprising a drug molecule, e.g. 5′-DFUR, bonded to one or two macromolecules of a hydrophobic polymer is provided. A spherical micelle with core-shell structure is formed by self-aggregation of said amphiphilic copolymer. It discloses a micelle-like nanoparticle comprising one or more said amphiphilic copolymers. The nanoparticles contain said drug molecules innately with no need to encapsulate the desired drug into the nanoparticles. The nanoparticles can serve as micellar drug carriers for delivering the drug. A nanocarrier comprising said nanoparticle and an active water-insoluble substance, e.g. SN-38, Camptothecin, encapsulated in the nanoparticle is also disclosed. The nanocarriers can serve as a means of cocktail therapy to deliver a mixture of two kinds of drugs to affected parts.

Abstract translation: 本发明公开了一种包含亲水链段和疏水片段的梳状两亲性共聚物。 它还公开了一种用于合成所述两亲性共聚物的新型制备方法。 包含药物分子的新型引发剂。 提供了与一个或两个大分子的疏水性聚合物键合的5'-DFUR。 通过所述两亲共聚物的自聚集形成具有核 - 壳结构的球形胶束。 它公开了包含一种或多种所述两亲性共聚物的胶束样纳米颗粒。 纳米颗粒本身含有所述药物分子，而不需要将所需药物包封到纳米颗粒中。 纳米颗粒可以用作用于递送药物的胶束药物载体。 包含所述纳米颗粒和活性水不溶性物质的纳米载体，例如。 还公开了包封在纳米颗粒中的喜树碱SN-38。 纳米载体可以作为鸡尾酒疗法的一种手段，将两种药物的混合物递送到受影响的部位。

公开(公告)号：US07776223B2

公开(公告)日：2010-08-17

申请号：US12173030

申请日：2008-07-15

Applicant: Kuo-Yung Chang ,  Heng-Shiung Shen ,  Li Ma ,  Chung-Sheng Chen ,  Tsu-Man Chen

Inventor： Kuo-Yung Chang ,  Heng-Shiung Shen ,  Li Ma ,  Chung-Sheng Chen ,  Tsu-Man Chen

IPC: B01D21/02

CPC classification number: B01D21/2483 ,  C02F2001/007 ,  C02F2101/006 ,  G21F9/06 ,  G21F9/30

Abstract: This present invention is related to a method of collecting high-level radioactive contaminated uranium powder underwater. It utilizes a long rod fixed to the pipe of the sewage pump at bottom, and takes another end of the sewage pump to connect to the sediment bag to collect uranium powder which is dispersed and contaminates the pond. Inhaling the pond water contains uranium powder into the sediment bag by sewage pump that is joined to a collecting can under it and waiting for precipitation of the powder. When the uranium powder in the sediment bag is completely precipitated into the collecting can, operator can utilize submersible pump to drain the pond water from the sediment bag. Operator may hold the cable wire of the uranium powder collecting can manually to move it to the collecting shelf and repeat the process several times until the high-level radioactive uranium powder in the contaminated pond are all collected on the uranium powder collecting shelf.

公开(公告)号：US07798951B2

公开(公告)日：2010-09-21

申请号：US11848261

申请日：2007-08-31

Applicant: Kuo-Yung Chang

Inventor： Kuo-Yung Chang

IPC: B09B3/00

CPC classification number: G21F9/34 ,  G21F9/001 ,  G21F9/002 ,  Y10S588/90

Abstract: An apparatus for disposal of low-level surface radioactive pollutants has a container body which center has accommodating space with opening at its top. Around the accommodating space there is a layer of barrier space for holding water. At the periphery of the barrier space there is a non-barrier hollow channel for the accommodating space to connect outside. A rotating disk is located at the bottom of the accommodating space in the container body for holding and turning the low-level radioactive waste to be treated and also facilitating the worker to pass through the non-barrier hollow channel for cleaning task.

Abstract translation: 用于处置低水平表面放射性污染物的装置具有容器主体，其中心具有在其顶部开口的容纳空间。 在容纳空间周围有一层用于保持水的屏障空间。 在障碍空间的周边处有一个无障碍的中空通道，用于容纳空间连接到外面。 旋转盘位于容器主体的容纳空间的底部，用于保持和转动要处理的低放射性废物，并且还便于工人通过非屏障中空通道进行清洁任务。

公开(公告)号：US20090062592A1

公开(公告)日：2009-03-05

申请号：US11848261

申请日：2007-08-31

Applicant: Kuo-Yung Chang

Inventor： Kuo-Yung Chang

IPC: G21F9/00

CPC classification number: G21F9/34 ,  G21F9/001 ,  G21F9/002 ,  Y10S588/90

Abstract: An apparatus for disposal of low-level surface radioactive pollutants has a container body which center has accommodating space with opening at its top. Around the accommodating space there is a layer of barrier space for holding water. At the periphery of the barrier space there is a non-barrier hollow channel for the accommodating space to connect outside. A rotating disk is located at the bottom of the accommodating space in the container body for holding and turning the low-level radioactive waste to be treated and also facilitating the worker to pass through the non-barrier hollow channel for cleaning task.

Abstract translation: 用于处置低水平表面放射性污染物的装置具有容器主体，其中心具有在其顶部开口的容纳空间。 在容纳空间周围有一层用于保持水的屏障空间。 在障碍空间的周边处有一个无障碍的中空通道，用于容纳空间连接到外面。 旋转盘位于容器主体的容纳空间的底部，用于保持和转动要处理的低放射性废物，并且还便于工人通过非屏障中空通道进行清洁任务。