公开(公告)号：US09826945B2

公开(公告)日：2017-11-28

申请号：US13821999

申请日：2011-06-09

申请人： Yoav Kimchy ,  Rafi Sommer

发明人： Yoav Kimchy ,  Rafi Sommer

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B1/00 ,  A61B1/04 ,  A61B6/06

CPC分类号： A61B6/4057 ,  A61B1/00027 ,  A61B1/041 ,  A61B5/6861 ,  A61B6/06 ,  A61B6/425 ,  A61B6/548 ,  A61B2562/162

摘要： An aspect of an embodiment of the invention, relates to an imaging capsule for scanning inside a living body with a fail-safe radiation mechanism that prevents the emission of radiation from the imaging capsule until the imaging capsule is instructed to emit radiation and power is available to activate a motor to unblock the emission of radiation. Optionally, when power is not available the imaging capsule automatically, blocks the emission of radiation.

公开(公告)号：US09392961B2

公开(公告)日：2016-07-19

申请号：US12825797

申请日：2010-06-29

申请人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

发明人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

IPC分类号： A61B5/05 ,  A61B5/07 ,  A61B5/03 ,  A61B5/00 ,  A61B6/00

CPC分类号： A61B5/073 ,  A61B5/036 ,  A61B5/42 ,  A61B6/4057 ,  A61B6/4241 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/482

摘要： An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.

摘要翻译： 公开了一种用于检测受试者的胃肠（GI）道的临床相关特征的装置和方法。 该装置包括被被检体吞咽并穿过被检体的胃肠道的胶囊，胶囊壳体，发射辐射的辐射源，被配置为相对于壳体旋转的可旋转准直器，并准直由第 辐射源和被配置为检测诸如光子，γ辐射，β辐射和响应于所发射的辐射产生的电子光子的颗粒的辐射检测器。 该装置还包括被配置为分析关于光子的数据的控制单元。 可以检测胶囊在GI道中的移动。 辐射源，辐射检测器和控制单元可以有利地集成在单个壳体内。

公开(公告)号：US09844354B2

公开(公告)日：2017-12-19

申请号：US12525672

申请日：2008-02-06

申请人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

发明人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

IPC分类号： A61B6/00

CPC分类号： A61B6/4057 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/485 ,  G06F19/00

摘要： An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected from a comparison between at least two images acquired with the apparatus. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.

公开(公告)号：US20130172740A1

公开(公告)日：2013-07-04

申请号：US13821999

申请日：2011-06-09

申请人： Yoav Kimchy ,  Rafi Sommer

发明人： Yoav Kimchy ,  Rafi Sommer

IPC分类号： A61B6/00

CPC分类号： A61B6/4057 ,  A61B1/00027 ,  A61B1/041 ,  A61B5/6861 ,  A61B6/06 ,  A61B6/425 ,  A61B6/548 ,  A61B2562/162

摘要： An aspect of an embodiment of the invention, relates to an imaging capsule for scanning inside a living body with a fail-safe radiation mechanism that prevents the emission of radiation from the imaging capsule until the imaging capsule is instructed to emit radiation and power is available to activate a motor to unblock the emission of radiation. Optionally, when power is not available the imaging capsule automatically, blocks the emission of radiation.

摘要翻译： 本发明的一个实施例的一个方面涉及一种用于利用故障安全辐射机构在生物体内进行扫描的成像胶囊，其防止来自成像胶囊的辐射的发射直到成像胶囊被指示发射辐射和电力可用 激活电机以解除辐射的发射。 可选地，当功率不可用时，成像胶囊自动地阻止辐射的发射。

公开(公告)号：US20100174184A1

公开(公告)日：2010-07-08

申请号：US12525672

申请日：2008-02-06

申请人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

发明人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

IPC分类号： A61B6/00 ,  A61M36/12

CPC分类号： A61B6/4057 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/485 ,  G06F19/00

摘要： An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected from a comparison between at least two images acquired with the apparatus. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.

摘要翻译： 公开了一种用于检测受试者的胃肠（GI）道的临床相关特征的装置和方法。 该装置包括被被检体吞咽并穿过被检体的胃肠道的胶囊，胶囊壳体，发射辐射的辐射源，被配置为相对于壳体旋转的可旋转准直器，并准直由第 辐射源和被配置为检测诸如光子，γ辐射，β辐射和响应于所发射的辐射产生的电子光子的颗粒的辐射检测器。 该装置还包括被配置为分析关于光子的数据的控制单元。 胶囊在胃肠道中的移动可以从用该装置获取的至少两个图像之间的比较来检测。 辐射源，辐射检测器和控制单元可以有利地集成在单个壳体内。

公开(公告)号：US20100303200A1

公开(公告)日：2010-12-02

申请号：US12825797

申请日：2010-06-29

申请人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

发明人： Yoav Kimchy ,  Yitzak Klein ,  Gideon Baum ,  Rafi Sommer

IPC分类号： G01N23/223

CPC分类号： A61B5/073 ,  A61B5/036 ,  A61B5/42 ,  A61B6/4057 ,  A61B6/4241 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/482

摘要： An apparatus and a method for detecting clinically-relevant features of the gastrointestinal (GI) tract of a subject are disclosed. The apparatus includes a capsule to be swallowed by a subject and passing through the GI tract of the subject, a capsule housing, a radiation source emitting radiation, a rotatable collimator configured to rotate with respect to the housing and to collimate the radiation emitted by the radiation source, and a radiation detector configured to detect particles, such as photons, gamma radiation, beta radiation and electrons photons generated responsive to the emitted radiation. The apparatus also includes a control unit configured to analyze data regarding the photons. Movement of the capsule in the GI tract can be detected. The radiation source, radiation detector and control unit may advantageously be integrated inside a single housing.

摘要翻译： 公开了一种用于检测受试者的胃肠（GI）道的临床相关特征的装置和方法。 该装置包括被被检体吞咽并穿过被检体的胃肠道的胶囊，胶囊壳体，发射辐射的辐射源，被配置为相对于壳体旋转的可旋转准直器，并准直由第 辐射源和被配置为检测诸如光子，γ辐射，β辐射和响应于所发射的辐射产生的电子光子的颗粒的辐射检测器。 该装置还包括被配置为分析关于光子的数据的控制单元。 可以检测胶囊在GI道中的移动。 辐射源，辐射检测器和控制单元可以有利地集成在单个壳体内。

公开(公告)号：US10677920B2

公开(公告)日：2020-06-09

申请号：US16492189

申请日：2018-04-12

申请人： Yoav Kimchy ,  Hadar Kimchy

发明人： Yoav Kimchy ,  Hadar Kimchy

IPC分类号： G01S15/88 ,  G01S7/527 ,  G01S7/54

摘要： A system for searching for underground entities in ground of an area, including a search probe configured to generate and deliver an acoustic signal into the ground of the area, wherein the acoustic signal uses a low frequency signal so that wavelengths of the acoustic signal are between 0.01-500 times the depth to the sought underground entity, two or more sensors positioned on the ground at about an equal distance from the search probe at different angles, an analysis device that receives measurements from the two or more sensors in the form of a measured echo signal responsive to the delivered acoustic signal, wherein said analysis device designates pairs of sensors and subtracts their echo signals to identify a difference indicating the existence of an underground entity.

公开(公告)号：US07787926B2

公开(公告)日：2010-08-31

申请号：US10596065

申请日：2004-12-16

申请人： Yoav Kimchy

发明人： Yoav Kimchy

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： A61B5/073 ,  A61B5/42 ,  A61B6/4057 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/481 ,  A61B6/482 ,  A61B6/483 ,  A61B6/485 ,  A61B6/547 ,  G06F19/00

摘要： Apparatus (40) is provided, including a capsule (50), adapted to be swallowed by a subject (54), the capsule (50) including (a) at least one radiation source (60), adapted to emit radiation having an energy of at least 10 keV, and (b) at least one photon detector (62), adapted to detect photons generated responsively to the emitted radiation, the photons having an energy of at least 10 keV. The apparatus (40) additionally includes a control unit (64), adapted to analyze data regarding the photons in order to generate information useful for identifying a clinically-relevant feature of a gastrointestinal (GI) tract (72) of the subject (54).

摘要翻译： 提供了一种装置（40），包括适于被受试者（54）吞咽的胶囊（50），所述胶囊（50）包括（a）至少一个辐射源（60），适于发射具有能量 至少10keV，和（b）至少一个光子检测器（62），适于检测响应于所发射的辐射产生的光子，所述光子具有至少10keV的能量。 装置（40）还包括控制单元（64），适于分析关于光子的数据，以便产生用于识别对象（54）的胃肠（GI）道（72）的临床相关特征的信息， 。

公开(公告)号：US09037219B2

公开(公告)日：2015-05-19

申请号：US13825018

申请日：2011-09-22

申请人： Gideon Baum ,  Yoav Kimchy

发明人： Gideon Baum ,  Yoav Kimchy

IPC分类号： A61B5/107 ,  A61B5/07 ,  A61B6/00 ,  A61B1/00 ,  A61B1/04 ,  A61B1/31 ,  A61B5/00 ,  A61M31/00

CPC分类号： A61B5/1076 ,  A61B1/00016 ,  A61B1/041 ,  A61B1/043 ,  A61B1/31 ,  A61B5/073 ,  A61B5/4255 ,  A61B5/7278 ,  A61B6/4057 ,  A61B6/425 ,  A61B6/481 ,  A61B6/483 ,  A61B6/485 ,  A61B6/547 ,  A61M31/005

摘要： A method of estimating distances in a colon of a subject, including: orally administering to a subject a contrast agent, orally administering an imaging capsule to the subject, emitting radiation from the imaging capsule at a location in the colon, detecting photons that are returned from an interaction of the radiation with an inner wall of the colon and contents of the colon, summating the detected photons with energies corresponding to X-ray fluorescence interactions to form a first count, summating the detected photons with energies corresponding to Compton back-scattering interactions to form a second count, determining the distance from the imaging capsule to the inner wall of the colon and a concentration of the contrast agent at the location of the imaging capsule in the colon using the values of the first count and the second count.

摘要翻译： 一种估计受试者的结肠中的距离的方法，包括：向受试者口服施用造影剂，向所述受试者口服施用成像胶囊，在所述结肠的位置处发射来自所述成像胶囊的辐射，检测返回的光子 从辐射与结肠的内壁和结肠内容物的相互作用中，将检测到的光子与对应于X射线荧光相互作用的能量相加以形成第一计数，将检测到的光子与对应于康普顿背散射的能量相加 相互作用以形成第二计数，使用第一计数和第二计数的值确定从成像胶囊到结肠的内壁的距离以及在冒号中的成像胶囊的位置处的造影剂的浓度。

公开(公告)号：US20140031642A1

公开(公告)日：2014-01-30

申请号：US13882503

申请日：2011-10-31

申请人： Yoav Kimchy ,  Anton Plotkin ,  Ronen Lifshitz ,  Oleg Obodovsky

发明人： Yoav Kimchy ,  Anton Plotkin ,  Ronen Lifshitz ,  Oleg Obodovsky

IPC分类号： A61B6/12

CPC分类号： A61B6/12 ,  A61B5/061 ,  A61B5/062 ,  A61B5/067 ,  A61B5/073 ,  A61B5/6882 ,  A61B5/7207 ,  A61B6/06 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/481 ,  A61B6/483 ,  A61B6/50 ,  A61B6/547 ,  A61B6/56

摘要： A system for detecting clinically-relevant features of a gastrointestinal (GI) tract of a subject. The system comprises an external magnetic field generator adapted to be affixed to a patient for generating at predetermined time intervals a magnetic field with respect to the subject. The magnetic field has a predetermined polarity and flux density, thereby establishing a patient coordinate system based upon the magnetic field. The system includes a capsule adapted to be swallowed by a subject. The system further includes at least one radiation source emitting X-ray or gamma radiation and at least one radiation detector. The radiation detector is configured to detect in a first energy window collimated X-ray fluorescence radiation from the X-ray contrast agent composition excited by the emitted radiation, and to detect a second energy window Compton-backscattered radiation from the X-ray contrast agent and the wall of the GI tract produced in response to the emitted radiation. The system includes a magnetic field detector configured to generate a first output responsive to a detected polarity and detected levels of flux density during exposure to the externally generated magnetic field. A processor generates a second output based upon relative changes in the first output, the first output varying as a function of relative changes in physical location or angular orientation of the capsule associated with movement of the capsule within the GI tract. A control unit configured to selectively enable or disable X-ray or gamma ray emissions from the capsule produced by the at least one radiation source based upon the second output, such that the GI tract is selectively irradiated upon detected movement of the capsule.

摘要翻译： 用于检测受试者的胃肠（GI）道的临床相关特征的系统。 该系统包括适于固定在患者身上的外部磁场发生器，用于以预定的时间间隔产生相对于被摄体的磁场。 磁场具有预定的极性和通量密度，从而基于磁场建立患者坐标系。 该系统包括适于被受试者吞咽的胶囊。 该系统还包括发射X射线或γ射线的至少一个辐射源和至少一个辐射探测器。 辐射检测器被配置为在第一能量窗口中检测来自由所发射的辐射激发的X射线造影剂组合物的准直X射线荧光辐射，并且检测来自X射线造影剂的第二能量窗康普顿背散射辐射 以及响应于所发射的辐射产生的胃肠道的壁。 该系统包括磁场检测器，其被配置为响应于检测到的极性而产生第一输出，并且在暴露于外部产生的磁场期间检测到磁通密度的水平。 处理器基于第一输出中的相对变化产生第二输出，第一输出作为与胶囊在GI道内的运动相关联的胶囊的物理位置或角度定向的相对变化的函数而变化。 控制单元，被配置为基于所述第二输出，选择性地启用或禁用由所述至少一个辐射源产生的所述胶囊的X射线或γ射线发射，使得根据检测到的所述胶囊的运动选择性地照射所述GI道。