公开(公告)号：US07635853B1

公开(公告)日：2009-12-22

申请号：US12250717

申请日：2008-10-14

Applicant: Yang Shi ,  Gregory Michael Burke

Inventor： Yang Shi ,  Gregory Michael Burke

IPC: G01N21/86 ,  B41J2/01

CPC classification number: B41J11/009 ,  G01N21/57 ,  G01N2021/4735 ,  G01N2021/556 ,  G01N2021/559 ,  G01N2021/8663

Abstract: A method is proved for analyzing frequency distribution of a reflection from a surface of a body to determine a type of body surface. Initially, a plurality of data points from a sensor that senses the reflection of the body's surface are provided. A first series of terms are summed together to provide a first magnitude, each term including a plurality of data points; wherein the plurality of data points being spaced apart by a first spacing. A second series of terms are summed together to provide a second magnitude, each term including a plurality of data points; wherein the plurality of data points being spaced apart by a second spacing. The first magnitude is compared to the second magnitude to determine the type of body surface.

Abstract translation: 证明了一种用于分析来自身体表面的反射的频率分布以确定体表的类型的方法。 首先，提供来自感测身体表面的反射的传感器的多个数据点。 将第一系列术语相加在一起以提供第一幅度，每个术语包括多个数据点; 其中所述多个数据点被间隔开第一间隔。 将第二系列项相加在一起以提供第二大小，每个术语包括多个数据点; 其中所述多个数据点间隔开第二间隔。 将第一幅度与第二幅度进行比较，以确定体表的类型。

公开(公告)号：US08971061B2

公开(公告)日：2015-03-03

申请号：US12687035

申请日：2010-01-13

Applicant: En Li ,  Yang Shi ,  Huanyu Lu ,  Junming Zhang ,  Yuancheng Ren

Inventor： En Li ,  Yang Shi ,  Huanyu Lu ,  Junming Zhang ,  Yuancheng Ren

IPC: H02M3/335

CPC classification number: H02M3/33507

Abstract: The present invention provides an off time control method and switching regulator using it. The current flowing through a switch is compared with a current threshold, and the switch is turned off if the current flowing through the switch is larger than the current threshold. The off time of the switch is determined by the load. The current threshold is variable at light load to prevent generating the audible noise and improve the whole efficiency.

Abstract translation: 本发明提供一种关闭时间控制方法和使用它的开关调节器。 将流过开关的电流与电流阈值进行比较，并且如果流过开关的电流大于电流阈值，则开关断开。 开关的关闭时间由负载决定。 电流阈值在轻负载时可变，防止产生可听噪声，提高整体效率。

公开(公告)号：US08238123B2

公开(公告)日：2012-08-07

申请号：US12817002

申请日：2010-06-16

Applicant: Junming Zhang ,  Yuanchang Ren ,  Jin Hu ,  Huanyu Lu ,  Yang Shi

Inventor： Junming Zhang ,  Yuanchang Ren ,  Jin Hu ,  Huanyu Lu ,  Yang Shi

IPC: H02M3/335

CPC classification number: H02M3/338 ,  H02M3/1563 ,  Y02B70/1425 ,  Y02B70/1433

Abstract: A frequency limitation method used in quasi-resonant control of a switching regulator is disclosed. The switching frequency is limited through setting a minimum time limit, such as a minimum switching period or a minimum OFF time. The minimum time limit may be a first time limit or a second time limit. The minimum time limit is changed into another value if the minimum voltage point approaches the minimum time limit point, so as to eliminate the audible noise.

Abstract translation: 公开了一种用于开关调节器的准谐振控制的频率限制方法。 通过设置最小时间限制（例如最小切换周期或最小关闭时间）来限制开关频率。 最小时限可以是第一时限或第二时间限制。 如果最小电压点接近最小时限，则将最小时间限制改为另一个值，以消除可听见的噪声。

公开(公告)号：US08223348B2

公开(公告)日：2012-07-17

申请号：US12332648

申请日：2008-12-11

Applicant: Thomas D. Pawlik ,  Yang Shi ,  David J. Glacherio ,  John S. Badger

Inventor： Thomas D. Pawlik ,  Yang Shi ,  David J. Glacherio ,  John S. Badger

IPC: G06F3/12 ,  G06K15/00

CPC classification number: B41J11/009 ,  B41J2/1752 ,  B41J2/1753 ,  G03G15/6508 ,  G03G2215/00616 ,  G03G2215/00751

Abstract: A printing system includes a media input location for storing a recording medium prior to transport within the printing system for subsequent printing; a light source directed toward an extended region of the media input location; an array of photosensors restricted to only a substantially perpendicular movement relative to a plane of the media input location; and an optical path including a first optical path section from the light source to the extended region of the media input location and a second optical path section from the extended region of the media input location to the array of photosensors.

Abstract translation: 打印系统包括用于在打印系统内传送之前存储记录介质以用于随后打印的介质输入位置; 指向所述媒体输入位置的扩展区域的光源; 光传感器阵列仅限于相对于介质输入位置的平面的基本上垂直的运动; 以及光路，其包括从介质输入位置的光源到扩展区域的第一光路部分和从介质输入位置的延伸区域到光电传感器阵列的第二光路部分。

公开(公告)号：US20110218144A1

公开(公告)日：2011-09-08

申请号：US12971678

申请日：2010-12-17

Applicant: John E. Baker ,  Yang Shi

Inventor： John E. Baker ,  Yang Shi

IPC: A61K38/18 ,  A61P7/04 ,  A61P9/10

CPC classification number: A61K38/196

Abstract: A therapeutic or prophylactic treatment method of ischemia, such as due to myocardial infarction, by administering thrombopoietin, alone or in combination with other drugs, to a patient suffering from or at risk of cardiac injury, such as myocardial ischemia. The thrombopoietin is administered in a concentration such that the subject's platelet count or production of platelets is not significantly affected.

Abstract translation: 通过将血小板生成素单独或与其它药物组合施用于患有或有心脏损伤风险的患者（例如心肌缺血）的局部缺血的治疗或预防治疗方法，例如由于心肌梗塞。 血小板生成素的给药浓度使得受试者的血小板计数或血小板的产生不受显着影响。

公开(公告)号：US07879318B2

公开(公告)日：2011-02-01

申请号：US11624030

申请日：2007-01-17

Applicant: John E. Baker ,  Yang Shi

Inventor： John E. Baker ,  Yang Shi

IPC: C07K14/475 ,  C07K14/52 ,  C07K14/715

CPC classification number: A61K38/196

Abstract: A therapeutic or prophylactic treatment method of ischemia, such as due to myocardial infarction, by administering thrombopoietin, alone or in combination with other drugs, to a patient suffering from or at risk of cardiac injury, such as myocardial ischemia. The thrombopoietin is administered in a concentration such that the subject's platelet count or production of platelets is not significantly affected.

Abstract translation: 通过将血小板生成素单独或与其它药物组合施用于患有或有心脏损伤风险的患者（例如心肌缺血）的局部缺血的治疗或预防治疗方法，例如由于心肌梗塞。 血小板生成素的给药浓度使得受试者的血小板计数或血小板的产生不受显着影响。

公开(公告)号：US07800089B2

公开(公告)日：2010-09-21

申请号：US12037966

申请日：2008-02-27

Applicant: Greg M. Burke ,  Brian Sinofsky ,  Yang Shi

Inventor： Greg M. Burke ,  Brian Sinofsky ,  Yang Shi

IPC: G01N21/86

CPC classification number: B41J2/2142 ,  B41J11/009 ,  B41J29/393

Abstract: A printing system includes a platen; a photosensor including an integrated lens; a light source configured to provide light, the light source including an integrated lens; and an aperture disposed to provide a field of view, the field of view being a portion of a plane parallel to the platen, wherein reflected light from the light source passes through the aperture to the photosensor without passing through an external lens.

Abstract translation: 打印系统包括压板; 包括集成透镜的光电传感器; 配置为提供光的光源，所述光源包括集成透镜; 以及设置成提供视野的孔，所述视场是平行于所述压板的平面的一部分，其中来自所述光源的反射光通过所述光圈而不穿过外部透镜。

公开(公告)号：US08937039B2

公开(公告)日：2015-01-20

申请号：US14081695

申请日：2013-11-15

Applicant: Hao Zhang ,  Yang Shi ,  Hao Xu ,  Kirkwood A. Pritchard, Jr.

Inventor： Hao Zhang ,  Yang Shi ,  Hao Xu ,  Kirkwood A. Pritchard, Jr.

IPC: A61K38/06 ,  A61P9/12 ,  A61P19/02 ,  C07K5/09

CPC classification number: C07K5/0815 ,  A61K38/00 ,  C07K5/0821

Abstract: The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.

Abstract translation: 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。

公开(公告)号：US20140194342A1

公开(公告)日：2014-07-10

申请号：US14081695

申请日：2013-11-15

Applicant: Hao Zhang ,  Yang Shi ,  Hao Xu ,  Kirkwood A. Pritchard, JR.

Inventor： Hao Zhang ,  Yang Shi ,  Hao Xu ,  Kirkwood A. Pritchard, JR.

IPC: C07K5/09

CPC classification number: C07K5/0815 ,  A61K38/00 ,  C07K5/0821

Abstract: The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.

Abstract translation: 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。

公开(公告)号：US20130210888A1

公开(公告)日：2013-08-15

申请号：US13693601

申请日：2012-12-04

Applicant: Yang Shi ,  Yujiang Shi

Inventor： Yang Shi ,  Yujiang Shi

IPC: C12Q1/26 ,  A61K45/06 ,  A61K31/713

CPC classification number: C12Q1/26 ,  A61K31/713 ,  A61K45/06 ,  G01N2333/906 ,  G01N2500/02

Abstract: LSD1, a homolog of nuclear amine oxidases, functions as a histone demethylase and transcriptional co-repressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription. Lysine demethylation occurs via an oxidation reaction that generates formaldehyde. Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant de-repression of target genes, suggesting that LSD1 represses transcription via histone demethylation. The results thus identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histone methylases and demethylases.

Abstract translation: LSD1是核胺氧化酶的同源物，用作组蛋白脱甲基酶和转录共抑制子。 LSD1特异性去甲基化组蛋白H3赖氨酸4，其与活性转录相关。 通过产生甲醛的氧化反应发生赖氨酸去甲基化。 重要的是，RNAi抑制LSD1导致H3赖氨酸4甲基化和伴随的靶基因去抑制的增加，这表明LSD1通过组蛋白去甲基化抑制转录。 因此，结果鉴定了从耻垢分枝杆菌保守的人组蛋白去甲基化酶，并揭示组蛋白甲基化和脱甲基酶的组蛋白甲基化的动态调节。