公开(公告)号：US20230338420A1

公开(公告)日：2023-10-26

申请号：US18165244

申请日：2023-02-06

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Aditi Majumder ,  Portia Smith ,  Anna Huttenlocher ,  David Bennin

IPC: A61K35/15 ,  C12N5/0786 ,  C12N5/0787 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K35/15 ,  C12N5/0645 ,  C12N5/0642 ,  C12N15/907 ,  C12N15/11 ,  C12N9/22 ,  A61K39/39558 ,  A61P35/00 ,  C12N2506/45 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/22 ,  C12N2501/145 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2310/20 ,  C12N2800/80

Abstract: The disclosure generally relates to methods for producing macrophages and neutrophils serum-free and feeder-free conditions from SIRPα inhibited pluripotent stem cells. The disclosure further relates to SIRPα inhibited macrophages and neutrophils and uses thereof.