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公开(公告)号：US20180119104A1
公开(公告)日：2018-05-03
申请号：US15835850
申请日：2017-12-08
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Akhilesh Kumar
CPC classification number: C12N5/0661 , A61K35/28 , A61K35/34 , A61K35/44 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2501/999 , C12N2506/02 , C12N2506/1346 , C12N2506/45
Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.
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2.发明申请公开(公告)号：US20210355441A1
公开(公告)日：2021-11-18
申请号：US17323715
申请日：2021-05-18
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Ho Sun Jung
Abstract: The present invention provides methods of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. The methods involve inducing the expression of a SOX17 transgene in human pluripotent stem cells starting at day 2 of differentiation. Stem cells that express the SOX17 transgene are also provided.
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公开(公告)号：US11091738B2
公开(公告)日：2021-08-17
申请号：US15835850
申请日：2017-12-08
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Akhilesh Kumar
Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.
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公开(公告)号：US20250145958A1
公开(公告)日：2025-05-08
申请号：US18819158
申请日：2024-08-29
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： Igor Slukvin , Akhilesh Kumar
Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitor, and methods and compositions for clinical applications in the field of regenerative medicine.
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公开(公告)号：US12098390B2
公开(公告)日：2024-09-24
申请号：US17403202
申请日：2021-08-16
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： Igor Slukvin , Akhilesh Kumar
CPC classification number: C12N5/0661 , A61K35/34 , A61K35/44 , A61K35/28 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2501/999 , C12N2506/02 , C12N2506/1346 , C12N2506/45
Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.
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Patent Agency Ranking
公开(公告)号：US10106771B2
公开(公告)日：2018-10-23
申请号：US15684647
申请日：2017-08-23
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Irina Elcheva
IPC: C12N5/00 , C12N5/0735 , C12N15/00 , C12N5/0789 , C12N15/66 , C12N5/071 , C12N15/11
Abstract: Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.
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7.发明公开公开(公告)号：US20240084257A1
公开(公告)日：2024-03-14
申请号：US18463211
申请日：2023-09-07
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Ho Sun Jung
IPC: C12N5/0783 , A61K35/17 , A61K35/19 , C12N5/078
CPC classification number: C12N5/0646 , A61K35/17 , A61K35/19 , C12N5/0644 , C12N2501/60 , C12N2506/45
Abstract: This disclosure provides reagents and methods for producing NK progenitor cells, NK cells, megakaryocytes and CAR derivatives thereof from hematopoietic stem cells. Pharmaceutical compositions comprising NK progenitor cells produced by the reagents and methods of the invention and immunotherapeutic methods using these pharmaceutical compositions are also provided.
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8.发明申请公开(公告)号：US20190144823A1
公开(公告)日：2019-05-16
申请号：US16143112
申请日：2018-09-26
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Irina Elcheva
IPC: C12N5/0735 , C12N15/00 , C12N15/66 , C12N5/0789 , C12N5/071 , C12N15/11
Abstract: Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.
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公开(公告)号：US09868939B2
公开(公告)日：2018-01-16
申请号：US14303428
申请日：2014-06-12
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： Igor Slukvin , Akhilesh Kumar
CPC classification number: C12N5/0661 , A61K35/28 , A61K35/34 , A61K35/44 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2501/999 , C12N2506/02 , C12N2506/1346 , C12N2506/45
Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.
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10.发明申请公开(公告)号：US20180010124A1
公开(公告)日：2018-01-11
申请号：US15684647
申请日：2017-08-23
Applicant: Wisconsin Alumni Research Foundation
Inventor： Igor Slukvin , Irina Elcheva
IPC: C12N15/11 , C12N15/66 , C12N5/0789 , C12N15/00
CPC classification number: C12N5/0606 , C12N5/0608 , C12N5/0647 , C12N15/00 , C12N15/11 , C12N15/66 , C12N2501/60 , C12N2501/998 , C12N2506/02 , C12N2506/45 , C12N2510/00 , C12N2740/16043
Abstract: Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.
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