Invention Grant
- Patent Title: Induction of hemogenic endothelium from pluripotent stem cells by forced expression of transcription factors
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Application No.: US15684647Application Date: 2017-08-23
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Publication No.: US10106771B2Publication Date: 2018-10-23
- Inventor: Igor Slukvin , Irina Elcheva
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/0735 ; C12N15/00 ; C12N5/0789 ; C12N15/66 ; C12N5/071 ; C12N15/11
Abstract:
Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.
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