公开(公告)号：US20240084257A1

公开(公告)日：2024-03-14

申请号：US18463211

申请日：2023-09-07

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Ho Sun Jung

IPC: C12N5/0783 ,  A61K35/17 ,  A61K35/19 ,  C12N5/078

CPC classification number: C12N5/0646 ,  A61K35/17 ,  A61K35/19 ,  C12N5/0644 ,  C12N2501/60 ,  C12N2506/45

Abstract: This disclosure provides reagents and methods for producing NK progenitor cells, NK cells, megakaryocytes and CAR derivatives thereof from hematopoietic stem cells. Pharmaceutical compositions comprising NK progenitor cells produced by the reagents and methods of the invention and immunotherapeutic methods using these pharmaceutical compositions are also provided.

公开(公告)号：US20210355441A1

公开(公告)日：2021-11-18

申请号：US17323715

申请日：2021-05-18

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Ho Sun Jung

IPC: C12N5/078 ,  C12N15/63

Abstract: The present invention provides methods of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. The methods involve inducing the expression of a SOX17 transgene in human pluripotent stem cells starting at day 2 of differentiation. Stem cells that express the SOX17 transgene are also provided.

公开(公告)号：US20240156963A1

公开(公告)日：2024-05-16

申请号：US18302636

申请日：2023-04-18

Applicant: Wisconsin Alumni Research Foundation

Inventor： James Thomson ,  Jue Zhang ,  Igor Slukvin ,  Aditi Majumder ,  Ho Sun Jung

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N5/0786 ,  C12N5/0787

CPC classification number: A61K39/464471 ,  A61K39/461 ,  A61K39/4613 ,  A61K39/4614 ,  A61K39/4631 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/3084 ,  C12N5/0642 ,  C12N5/0645 ,  C12N5/0646 ,  C12N2506/45 ,  C12N2510/00

Abstract: This disclosure provides genetically engineered immune cells that express an anti-GD2 chimeric antigen receptor, methods of generating these cells, and methods of treating tumors using the genetically engineered cells.

公开(公告)号：US20230323301A1

公开(公告)日：2023-10-12

申请号：US18296895

申请日：2023-04-06

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： Anna Huttenlocher ,  Igor Slukvin ,  Morgan Giese ,  Ho Sun Jung ,  David Bennin

IPC: C12N5/0787 ,  C12N5/074 ,  C12N9/22 ,  C12N9/12 ,  C07K14/705 ,  C07K14/74

CPC classification number: C12N5/0642 ,  C12N5/0696 ,  C12N9/22 ,  C12N9/12 ,  C07K14/70532 ,  C07K14/70539 ,  C12N5/0031

Abstract: This disclosure provides methods for producing neutrophils under serum-free and feeder-free conditions from protein tyrosine phosphatase 1B (PTP1b)-inhibited pluripotent stem cells. The disclosure further provides PTP1b inhibited neutrophils and uses thereof. Also disclosed are methods for producing human neutrophil-DC hybrid cells and human neutrophil-DC hybrid cells produced thereby.