公开(公告)号：US11980654B2

公开(公告)日：2024-05-14

申请号：US17481490

申请日：2021-09-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Anna Huttenlocher ,  Deane Mosher ,  Valeriu Bortnov ,  David Bennin ,  Ruth Anne Houseright ,  Frances M Smith

IPC: A61K38/18 ,  A61P17/02

CPC classification number: A61K38/18 ,  A61P17/02

Abstract: A method to inhibit neutrophil recruitment to damaged tissue, thereby inhibiting inflammation in a subject. The method includes administering to an anti-inflammatory amount of a myeloid-derived growth factor (“MYDGF”). Also disclosed are corresponding pharmaceutical compositions of matter containing the MYDGF.

公开(公告)号：US20240299494A1

公开(公告)日：2024-09-12

申请号：US18632978

申请日：2024-04-11

Applicant: Wisconsin Alumni Research Foundation

Inventor： Anna Huttenlocher ,  Deane Mosher ,  Valeriu Bortnov ,  David Bennin ,  Ruth Anne Houseright ,  Frances M. Smith

IPC: A61K38/18 ,  A61P17/02

CPC classification number: A61K38/18 ,  A61P17/02

Abstract: A method to inhibit neutrophil recruitment to damaged tissue, thereby inhibiting inflammation in a subject. The method includes administering to an anti-inflammatory amount of a myeloid-derived growth factor (“MYDGF”). Also disclosed are corresponding pharmaceutical compositions of matter containing the MYDGF.

公开(公告)号：US20230338420A1

公开(公告)日：2023-10-26

申请号：US18165244

申请日：2023-02-06

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Aditi Majumder ,  Portia Smith ,  Anna Huttenlocher ,  David Bennin

IPC: A61K35/15 ,  C12N5/0786 ,  C12N5/0787 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K35/15 ,  C12N5/0645 ,  C12N5/0642 ,  C12N15/907 ,  C12N15/11 ,  C12N9/22 ,  A61K39/39558 ,  A61P35/00 ,  C12N2506/45 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/22 ,  C12N2501/145 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2310/20 ,  C12N2800/80

Abstract: The disclosure generally relates to methods for producing macrophages and neutrophils serum-free and feeder-free conditions from SIRPα inhibited pluripotent stem cells. The disclosure further relates to SIRPα inhibited macrophages and neutrophils and uses thereof.

公开(公告)号：US20230323301A1

公开(公告)日：2023-10-12

申请号：US18296895

申请日：2023-04-06

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： Anna Huttenlocher ,  Igor Slukvin ,  Morgan Giese ,  Ho Sun Jung ,  David Bennin

IPC: C12N5/0787 ,  C12N5/074 ,  C12N9/22 ,  C12N9/12 ,  C07K14/705 ,  C07K14/74

CPC classification number: C12N5/0642 ,  C12N5/0696 ,  C12N9/22 ,  C12N9/12 ,  C07K14/70532 ,  C07K14/70539 ,  C12N5/0031

Abstract: This disclosure provides methods for producing neutrophils under serum-free and feeder-free conditions from protein tyrosine phosphatase 1B (PTP1b)-inhibited pluripotent stem cells. The disclosure further provides PTP1b inhibited neutrophils and uses thereof. Also disclosed are methods for producing human neutrophil-DC hybrid cells and human neutrophil-DC hybrid cells produced thereby.

公开(公告)号：US20220168390A1

公开(公告)日：2022-06-02

申请号：US17481490

申请日：2021-09-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Anna Huttenlocher ,  Deane Mosher ,  Valeriu Bortnov ,  David Bennin

IPC: A61K38/18 ,  A61P17/02

Abstract: A method to inhibit neutrophil recruitment to damaged tissue, thereby inhibiting inflammation in a subject. The method includes administering to an anti-inflammatory amount of a myeloid-derived growth factor (“MYDGF”). Also disclosed are corresponding pharmaceutical compositions of matter containing the MYDGF.