公开(公告)号：US20230265149A1

公开(公告)日：2023-08-24

申请号：US18047856

申请日：2022-10-19

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  David ZHANG ,  Sudip MUKHERJEE ,  Maria RUOCCO ,  Michael DOERFERT ,  Amanda NASH ,  Samira AGHLARA-FOTOVAT

IPC分类号： C07K14/55 ,  C12N5/079 ,  C12N5/00 ,  A61P35/00

CPC分类号： C07K14/55 ,  C12N5/0621 ,  C12N5/0012 ,  A61P35/00

摘要： The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver antigenic therapeutic reagents, such as IL-2.

公开(公告)号：US20240041939A1

公开(公告)日：2024-02-08

申请号：US18067204

申请日：2022-12-16

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Amanda NASH ,  Samira AGHLARA-FOTOVAT

IPC分类号： A61K35/36 ,  C12N5/071 ,  C07K14/54 ,  C12N11/08 ,  A61P35/00

CPC分类号： A61K35/36 ,  C12N5/0602 ,  C07K14/5434 ,  C12N11/08 ,  A61P35/00

摘要： The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver therapeutic reagents, such as IL-12 and/or IL-12 and methods of using the same to treat conditions, such as cancer.

公开(公告)号：US20230210908A1

公开(公告)日：2023-07-06

申请号：US17904106

申请日：2021-02-11

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Amanda NASH ,  Bhagyashree Kishor BACHHAV ,  Carlos Alberto ORIGEL MARMOLEJO ,  Damon BERMAN ,  Christian SCHREIB ,  Laura SEGATORI ,  Alen TRUBELJA ,  Oleg A. IGOSHIN ,  Andrew D. HECHT

IPC分类号： A61K35/36 ,  C12N5/071 ,  C12N15/90 ,  C12N15/63 ,  C07K14/715 ,  C07K14/55

CPC分类号： A61K35/36 ,  C07K14/55 ,  C07K14/7155 ,  C12N5/0686 ,  C12N15/635 ,  C12N15/907 ,  A61K38/00 ,  C12N2830/001 ,  C12N2840/203

摘要： The present disclosure provides expression constructs designed to provide for expression of therapeutic proteins from engineered cells. The engineered cells may be encapsulated into implantable elements that allow for the therapeutic protein to be released into from the capsule while protecting the cell from the immune system of a patient into which the capsule is implanted.

公开(公告)号：US20240041755A1

公开(公告)日：2024-02-08

申请号：US18258550

申请日：2021-12-17

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Amanda NASH ,  Boram KIM ,  Damon BERMAN ,  Lauren CHENG ,  David ZHANG

IPC分类号： A61K9/00 ,  A61K47/36 ,  A61K9/50 ,  A61K35/12 ,  C07K14/52 ,  A61K39/00

CPC分类号： A61K9/0024 ,  A61K47/36 ,  A61K9/5036 ,  A61K35/12 ,  C07K14/52 ,  A61K39/0011

摘要： The present disclosure relates to implantable constructs and related compositions comprising a plurality of cells producing antigens and/or immune effector molecules.

公开(公告)号：US20220313599A1

公开(公告)日：2022-10-06

申请号：US17633716

申请日：2020-08-07

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Amanda NASH ,  Maria Isabel JARVIS-RUOCCO ,  Sudip MUKHERJEE ,  Michael David DOERFERT ,  Samira AGHLARA-FOTOVAT ,  David Yu ZHANG

IPC分类号： A61K9/00 ,  A61K45/06

摘要： The present disclosure relates to implantable constructs designed to deliver antigenic therapeutic reagents to a subject while providing protection from host immune responses. In certain aspects, the constructs are designed to degrade over time or upon a particular signal, thereby providing control of the length of time the therapeutic agent is delivered to the subject.