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1.发明授权公开(公告)号：US06566363B2
公开(公告)日：2003-05-20
申请号：US09923432
申请日：2001-08-08
IPC分类号： A61K31429
CPC分类号： C07D513/04 , C07D277/42
摘要： Pyrazole-thiazole compounds that modulate and/or inhibit the activity of cyclin-dependent kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating cyclin-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制细胞周期蛋白依赖性激酶活性的吡唑 - 噻唑化合物。 这些化合物和含有它们的药物组合物能够介导细胞周期蛋白依赖性疾病调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管生成和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病，青光眼，类风湿性关节炎， 和银屑病，通过施用有效量的这种化合物。
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公开(公告)号：US07718656B2
公开(公告)日：2010-05-18
申请号：US11478129
申请日：2006-06-28
申请人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
发明人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
IPC分类号： A61K31/495 , A61K31/445 , A61K31/215 , C07D241/04 , C07D211/06 , C07C69/76
CPC分类号： C07C405/00 , C07D207/08 , C07D295/12 , C07D295/13
摘要： Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素酰胺的硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20090062296A1
公开(公告)日：2009-03-05
申请号：US11478129
申请日：2006-06-28
申请人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
发明人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
IPC分类号： A61K31/495 , C07C233/01 , A61K31/164 , C07C69/52 , A61K31/445 , A61P27/02 , A61P9/12 , C07D211/06 , A61K31/215 , C07D241/04
CPC分类号： C07C405/00 , C07D207/08 , C07D295/12 , C07D295/13
摘要： Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素酰胺的硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US07799784B2
公开(公告)日：2010-09-21
申请号：US12162529
申请日：2007-02-02
申请人： Francesca Benedini , Francesco Impagnatiello , Stefano Biondi , Ennio Ongini , Wesley Kwan Mung Chong
发明人： Francesca Benedini , Francesco Impagnatiello , Stefano Biondi , Ennio Ongini , Wesley Kwan Mung Chong
IPC分类号： A61K31/495
CPC分类号： C07D233/50 , C07D239/76
摘要： The present invention relates to alpha2-adrenergic receptor agonist nitrooxyderivatives, including the following structure, having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of ocular diseases, in particular high intraocular pressure and glaucoma.
摘要翻译： 本发明涉及具有改善的药理活性和增强的耐受性的α2-肾上腺素能受体激动剂硝基氧化酶，包括以下结构。 它们可用于治疗眼部疾病，特别是高眼内压和青光眼。
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公开(公告)号：US08101658B2
公开(公告)日：2012-01-24
申请号：US12991855
申请日：2009-05-11
申请人： Francesca Benedini , Stefano Biondi , Valerio Chiroli , Wesley Kwan Mung Chong , Liming Dong , Achim Hans-Peter Krauss , Fabio Nicoli , Ganesh Prasanna , William Francois Vernier , Yi Yang
发明人： Francesca Benedini , Stefano Biondi , Valerio Chiroli , Wesley Kwan Mung Chong , Liming Dong , Achim Hans-Peter Krauss , Fabio Nicoli , Ganesh Prasanna , William Francois Vernier , Yi Yang
IPC分类号： A61K31/04 , A61K31/16 , C07C203/04 , C07C291/00
CPC分类号： C07C405/00 , C07C291/02 , C07C2601/02 , C07C2601/08
摘要： Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素的硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20110092590A1
公开(公告)日：2011-04-21
申请号：US12991855
申请日：2009-05-11
申请人： Francesca Benedini , Stefano Biondi , Valerio Chiroli , Wesley Kwan Mung Chong , Liming Dong , Achim Hans-Peter Krauss , Fabio Nicoli , Ganesh Prasanna , William Francois Vernier , Yi Yang
发明人： Francesca Benedini , Stefano Biondi , Valerio Chiroli , Wesley Kwan Mung Chong , Liming Dong , Achim Hans-Peter Krauss , Fabio Nicoli , Ganesh Prasanna , William Francois Vernier , Yi Yang
IPC分类号： A61K31/21 , C07C203/04 , A61P27/02 , A61P27/06
CPC分类号： C07C405/00 , C07C291/02 , C07C2601/02 , C07C2601/08
摘要： Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素的硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20100256357A1
公开(公告)日：2010-10-07
申请号：US12376677
申请日：2007-07-30
申请人： Wesley Kwan Mung Chong , Andrew M. Haidle , Martha Alicia Ornelas , Lin Li , Seiji Nukui , Eugene Yuanjin Rui , Min Teng , William Francois Vernier , Joe Zhongxiang Zhou
发明人： Wesley Kwan Mung Chong , Andrew M. Haidle , Martha Alicia Ornelas , Lin Li , Seiji Nukui , Eugene Yuanjin Rui , Min Teng , William Francois Vernier , Joe Zhongxiang Zhou
IPC分类号： C07D413/06 , C07D249/12 , C07D413/12 , C07D401/06 , C07D403/06
CPC分类号： C07D249/10 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/54 , C07D233/90 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D498/04
摘要： Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
摘要翻译： 公开了含有可用于控制眼内压的化合物的磺酰胺和药物组合物。 还公开了通过施用组合物来控制眼内压的方法。
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公开(公告)号：US20080318965A1
公开(公告)日：2008-12-25
申请号：US12162529
申请日：2007-02-02
申请人： Francesca Benedini , Francesco Impagnatiello , Stefano Biondi , Ennio Ongini , Wesley Kwan Mung Chong
发明人： Francesca Benedini , Francesco Impagnatiello , Stefano Biondi , Ennio Ongini , Wesley Kwan Mung Chong
IPC分类号： C07D403/12 , A61K31/4985 , A61K31/4164 , C07D233/44 , A61P27/02
CPC分类号： C07D233/50 , C07D239/76
摘要： The present invention relates to alpha2-adrenergic receptor agonist nitrooxyderivatives having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of ocular diseases, in particular high intraocular pressure and glaucoma.
摘要翻译： 本发明涉及具有改善的药理活性和增强的耐受性的α2-肾上腺素能受体激动剂硝基氧化酶。 它们可用于治疗眼部疾病，特别是高眼内压和青光眼。
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9.发明授权Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation 失效噻唑苯甲酰胺衍生物和抑制细胞增殖的药物组合物公开(公告)号：US06720346B2
公开(公告)日：2004-04-13
申请号：US10190219
申请日：2002-07-05
申请人： Shao Song Chu , Larry Andrew Alegria , Ted Michael Bleckman , Wesley Kwan Mung Chong , Rohit K. Duvadie , Lin Li , Siegfried Heinz Reich , William Henry Romines, III , Michael B. Wallace , Yi Yang
发明人： Shao Song Chu , Larry Andrew Alegria , Ted Michael Bleckman , Wesley Kwan Mung Chong , Rohit K. Duvadie , Lin Li , Siegfried Heinz Reich , William Henry Romines, III , Michael B. Wallace , Yi Yang
IPC分类号： A61K31425
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/12 , C07D491/10
摘要： Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.
摘要翻译： 描述了具有单 - 二取代苯甲酰胺的氨基噻唑化合物由式（I）表示，并且描述了其药学上可接受的盐，药学上可接受的前药，药学活性代谢物和所述代谢物的药学上可接受的盐。这些试剂调节和/或抑制 蛋白激酶的细胞增殖和活性，并且可用作治疗恶性肿瘤和其它疾病的药物。
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