公开(公告)号：US06462060B2

公开(公告)日：2002-10-08

申请号：US09930255

申请日：2001-08-16

申请人： Wesley Kwon Mung Chong ,  Rohit Kumar Duvadie

发明人： Wesley Kwon Mung Chong ,  Rohit Kumar Duvadie

IPC分类号： C07D28514

CPC分类号： C07D235/02 ,  C07D249/16 ,  C07D271/12 ,  C07D285/14

摘要： Compounds with heterocyclic-hydroxyimino-fluorene nuclei that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

公开(公告)号：US20050101595A1

公开(公告)日：2005-05-12

申请号：US10783887

申请日：2004-02-20

申请人： Shao Song Chu ,  Larry Alegria ,  Ted Bleckman ,  Wesley Chong ,  Rohit Kumar Duvadie ,  Lin Li ,  William Romines ,  Yi Yang

发明人： Shao Song Chu ,  Larry Alegria ,  Ted Bleckman ,  Wesley Chong ,  Rohit Kumar Duvadie ,  Lin Li ,  William Romines ,  Yi Yang

IPC分类号： A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61P35/00 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D513/04

CPC分类号： C07D417/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/08 ,  C07D513/04

摘要： Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, pharmaceutically active metabolite or pharmaceutically acceptable salt of said compound, or metabolite thereof, modulate and/or inhibit the cell proliferation and activity of protein kinases. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.

摘要翻译： 由式（I）表示的2-氨基位置的含N环烷基的氨基噻唑化合物或所述化合物的药学上可接受的前药，所述化合物或其代谢物的药学活性代谢物或药学上可接受的盐调节和/ 或抑制蛋白激酶的细胞增殖和活性。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及通过施用有效量的这些化合物来治疗恶性肿瘤和其它病症的方法。

公开(公告)号：US06566363B2

公开(公告)日：2003-05-20

申请号：US09923432

申请日：2001-08-08

申请人： Wesley Kwan Mung Chong ,  Rohit Kumar Duvadie

发明人： Wesley Kwan Mung Chong ,  Rohit Kumar Duvadie

IPC分类号： A61K31429

CPC分类号： C07D513/04 ,  C07D277/42

摘要： Pyrazole-thiazole compounds that modulate and/or inhibit the activity of cyclin-dependent kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating cyclin-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

摘要翻译： 描述了调节和/或抑制细胞周期蛋白依赖性激酶活性的吡唑 - 噻唑化合物。 这些化合物和含有它们的药物组合物能够介导细胞周期蛋白依赖性疾病调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管生成和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病，青光眼，类风湿性关节炎， 和银屑病，通过施用有效量的这种化合物。