公开(公告)号：US06620828B2

公开(公告)日：2003-09-16

申请号：US09783584

申请日：2001-02-15

申请人： Shao Song Chu ,  Larry Andrew Alegria ,  Steven Lee Bender ,  Suzanne Pritchett Benedict ,  Allen J. Borchardt ,  Robert Steve Kania ,  Mitchell David Nambu ,  Anna Maria Tempczyk-Russell ,  Sepehr Sarshar ,  Dilip Bhumralkar ,  Zhengwei Peng ,  Michelle Yang

发明人： Shao Song Chu ,  Larry Andrew Alegria ,  Steven Lee Bender ,  Suzanne Pritchett Benedict ,  Allen J. Borchardt ,  Robert Steve Kania ,  Mitchell David Nambu ,  Anna Maria Tempczyk-Russell ,  Sepehr Sarshar ,  Dilip Bhumralkar ,  Zhengwei Peng ,  Michelle Yang

IPC分类号： C07D41704

CPC分类号： C07D417/04 ,  C07D277/38 ,  C07D277/62 ,  C07D417/14 ,  C07F9/6539 ,  C07F9/65583

摘要： Diaminothiazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

公开(公告)号：US06720346B2

公开(公告)日：2004-04-13

申请号：US10190219

申请日：2002-07-05

申请人： Shao Song Chu ,  Larry Andrew Alegria ,  Ted Michael Bleckman ,  Wesley Kwan Mung Chong ,  Rohit K. Duvadie ,  Lin Li ,  Siegfried Heinz Reich ,  William Henry Romines, III ,  Michael B. Wallace ,  Yi Yang

发明人： Shao Song Chu ,  Larry Andrew Alegria ,  Ted Michael Bleckman ,  Wesley Kwan Mung Chong ,  Rohit K. Duvadie ,  Lin Li ,  Siegfried Heinz Reich ,  William Henry Romines, III ,  Michael B. Wallace ,  Yi Yang

IPC分类号： A61K31425

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/42 ,  C07D417/12 ,  C07D491/10

摘要： Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

摘要翻译： 描述了具有单 - 二取代苯甲酰胺的氨基噻唑化合物由式（I）表示，并且描述了其药学上可接受的盐，药学上可接受的前药，药学活性代谢物和所述代谢物的药学上可接受的盐。这些试剂调节和/或抑制 蛋白激酶的细胞增殖和活性，并且可用作治疗恶性肿瘤和其它疾病的药物。