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    Antibodies against CXCR4 and methods of use thereof
    1.
    发明授权
    Antibodies against CXCR4 and methods of use thereof 有权
    抗CXCR4抗体及其使用方法

    公开(公告)号：US08329178B2

    公开(公告)日：2012-12-11

    申请号：US11883258

    申请日：2006-02-15

    Applicant: Wayne A. Marasco ,  Jianhua Sui ,  Chen Xu

    Inventor： Wayne A. Marasco ,  Jianhua Sui ,  Chen Xu

    IPC: A61K39/395 ,  C07K16/28 ,  C07K14/47 ,  C07K16/46 ,  C07K14/715

    CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/005 ,  C07K2317/21 ,  C07K2317/622

    Abstract: The invention provides human monoclonal antibodies or fragments thereof, that specifically bind to CXCR4. Disclosed are methods of use of such antibodies for the treatment and/or prevention of a CXCR4 disease or disorder such as cancer and X4-tropic HIV-1 infection Also provided are methods of use of such antibodies and antibody fragments for the treatment or prevention of cancer metastasis. The invention provides methods of mobilizing CD34+stem cells from the bone marrow and methods of blocking chemotaxis of CXCR4-expressing cells in response to SDF-1. Also provided are methods of use of the antibodies and fragments thereof for the prevention or treatment of graft-versus-host disease. Finally, the invention provides methods of inhibiting new tumor blood vessel formation and/or tumor cell angiogenesis.

    Abstract translation: 本发明提供特异性结合CXCR4的人单克隆抗体或其片段。 公开了使用这种抗体治疗和/或预防CXCR4疾病或病症如癌症和X4-嗜性HIV-1感染的方法。还提供了使用这种抗体和抗体片段来治疗或预防 癌转移。 本发明提供了从骨髓中移动CD34 +干细胞的方法以及阻断响应于SDF-1的CXCR4表达细胞趋化性的方法。 还提供了用于预防或治疗移植物抗宿主病的抗体及其片段的方法。 最后，本发明提供了抑制新的肿瘤血管形成和/或肿瘤细胞血管发生的方法。

    Antibodies to west nile virus polypeptides
    2.
    发明申请
    Antibodies to west nile virus polypeptides 审中-公开
    西尼罗病毒多肽的抗体

    公开(公告)号：US20090130123A1

    公开(公告)日：2009-05-21

    申请号：US11629825

    申请日：2005-06-15

    Applicant: Erol Fikrig ,  Hannah Gould ,  Raymond A. Koski ,  Michel Ledizet ,  Wayne A. Marasco ,  Jianhua Sui

    Inventor： Erol Fikrig ,  Hannah Gould ,  Raymond A. Koski ,  Michel Ledizet ,  Wayne A. Marasco ,  Jianhua Sui

    IPC: A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  C12N15/11 ,  C12N15/00 ,  C12P21/04 ,  A01K67/027 ,  A01H5/00 ,  A61K31/7088 ,  C12Q1/70

    CPC classification number: C07K16/1081 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/394

    Abstract: The present invention relates to anti-West Nile virus E protein (WNE) antibodies, including human antibodies, and antigen-binding portions thereof. In particular, the invention relates to such antibodies and portions that prevent, inhibit, or treat a flavivirus infection, including a West Nile Virus infection. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or that are portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-WNE antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-WNE antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis, prophylaxis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-WNE antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

    Abstract translation: 本发明涉及包含人抗体的抗西尼罗病毒E蛋白（WNE）抗体及其抗原结合部分。 特别地，本发明涉及预防，抑制或治疗黄病毒感染（包括西尼罗河病毒感染）的这些抗体和部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人类抗WNE抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗WNE抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断，预防和治疗的方法。 本发明还提供使用编码包含人抗WNE抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。

    Antibodies against CXCR4 and Methods of Use Thereof
    6.
    发明申请
    Antibodies against CXCR4 and Methods of Use Thereof 有权

    公开(公告)号：US20110250165A1

    公开(公告)日：2011-10-13

    申请号：US11883258

    申请日：2006-02-15

    Applicant: Wayne A. Marasco ,  Jianhun Sui ,  Chen Xu

    Inventor： Wayne A. Marasco ,  Jianhun Sui ,  Chen Xu

    IPC: A61K38/19 ,  A61K39/395 ,  A61P35/04 ,  A61P35/00 ,  A61P37/06 ,  C07K16/28 ,  A61P31/18

    CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/005 ,  C07K2317/21 ,  C07K2317/622

    Abstract: The invention provides human monoclonal antibodies, scFv antibodies, scFv-Fc fusions, a dAb (domain antibodies), Fab, Fab′ and F(ab)′2 fragments, single chain antibodies and/or minibodies that specifically bind to CXCR4. Also provided are methods of treating and/or preventing a CXCR4 disease or disorder such as cancer and X4-tropic HIV-I infection as well as uses of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of a CXCR4 disorder. The invention also provides methods of preventing diseases or disorders associated with CXCR4 function or expression. The invention further provides for the use of the antibodies (or fragments thereof) of the invention in the manufacture of a medicament for the prevention of diseases or disorders associated with CXCR4 expression. Also provided are methods of treating or preventing cancer metastasis in a patient suffering from a cancer involving tumor cells that express CXCR4. The invention also encompasses the use of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of cancer metastasis. The invention also includes methods of treating or preventing cancer metastasis in a patient suffering from a hypoxic tumor, such as any solid tumor characterized by HIF-dependent CXCR4 activation. The antibodies and fragments disclosed herein can be used in the manufacture of a medicament for the prevention of cancer metastasis in a patient suffering from a hypoxic tumor. The invention additionally provides methods of mobilizing CD34+ stem cells from the bone marrow as wells methods of blocking chemotaxis of CXCR4-expressing cells in response to SDF-1. Also provided are methods of treating or preventing graft-versus-host disease as well as the use of the antibodies and fragments thereof in the manufacture of a medicament for the prevention or treatment of GVHD. Finally, the invention also provides methods of inhibiting the formation of new tumor blood vessels and/or inhibiting tumor cell angiogenesis.

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