公开(公告)号：US20240166732A1

公开(公告)日：2024-05-23

申请号：US18383398

申请日：2023-10-24

申请人： West Virginia University Board of Governors on behalf of West Virginia University

发明人： Ali R. Rezai ,  Victor Finomore, JR. ,  Jeff Carpenter ,  Paul Lockman

IPC分类号： C07K16/18 ,  A61K9/50 ,  A61N7/00

CPC分类号： C07K16/18 ,  A61K9/50 ,  A61N7/00 ,  A61N2007/0021

摘要： A method of improving a neurodegenerative or cognitive disorder in a human patient suffering therefrom is provided by determining a target site of the human patient's brain that is affected by the neurodegenerative disorder or cognitive disorder and providing a therapy to the human patient. The therapy includes applying a low intensity focused ultrasound (LiFUS) sonication via an ultrasound delivery device to the target site based on an imaging parameter, a microbubble cavitation; an optical parameter, a bodily fluid parameter, or a physiological or anatomical parameter of the human patient's brain. A therapeutic agent is introduced to the target site before, after or during application of the LiFUS sonication.

公开(公告)号：US11209638B2

公开(公告)日：2021-12-28

申请号：US16026398

申请日：2018-07-03

申请人： West Virginia University

发明人： Paul Lockman ,  Afroz Mohammad ,  Neal Shah

IPC分类号： G02B21/34

摘要： A stage apparatus is disclosed for supporting and positioning a body tissue sample in a microscope. The stage apparatus has (a) an elongated base mount having a longitudinal body extending between a first end and a second end, (b) means for attaching the first end of the base to a mount or platform associated with the microscope, (c) a tissue mount having a tissue well attached to an elongated mount stem, the tissue well of sufficient size and shape to store the body tissue sample, and (d) means for attaching the second end of the base mount and the tissue mount, the tissue mount being removable and separable from the base mount.

公开(公告)号：US20190011689A1

公开(公告)日：2019-01-10

申请号：US16026398

申请日：2018-07-03

申请人： West Virginia University

发明人： Paul Lockman ,  Afroz Mohammad ,  Neal Shah

IPC分类号： G02B21/34

摘要： A stage apparatus is disclosed for supporting and positioning a body tissue sample in a microscope. The stage apparatus has (a) an elongated base mount having a longitudinal body extending between a first end and a second end, (b) means for attaching the first end of the base to a mount or platform associated with the microscope, (c) a tissue mount having a tissue well attached to an elongated mount stem, the tissue well of sufficient size and shape to store the body tissue sample, and (d) means for attaching the second end of the base mount and the tissue mount, the tissue mount being removable and separable from the base mount.

公开(公告)号：US11565251B2

公开(公告)日：2023-01-31

申请号：US16786335

申请日：2020-02-10

申请人： WEST VIRGINIA UNIVERSITY

发明人： Paul Lockman

IPC分类号： B01L3/00 ,  C12M3/06

摘要： A microfluidic device is useful for modelling drug transmission across the vasculature and vascular barriers. The device includes a frame, a fluid-permeable lumen configured to carry a fluid through the frame in a first direction, a first chamber surrounding the lumen, and a second chamber surrounding the first fluid-permeable chamber. At least one surface of the first chamber is configured for deposition of a first population of endothelial cells. An outer surface of the second chamber is configured for deposition a second population of cells. The second chamber is configured to carry a fluid through the frame in a second direction. The fluid-permeable lumen is configured to allow the fluid to permeate through a wall of the lumen into the first chamber, and the first chamber and the second chamber are in fluid communication with each other.