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公开(公告)号：US20240321426A1
公开(公告)日：2024-09-26
申请号：US18633597
申请日：2024-04-12
发明人： Ali Rezai , Victor Finomore , James Mahoney , Clay Marsh , Jeff Carpenter , Pierre D'haese , Marc Haut , Annahita Amireskandari
CPC分类号： G16H20/30 , A61N7/00 , A61M37/0092 , A61N2007/0026 , A61N2007/0039
摘要： Systems and methods are disclosed for providing focused ultrasound treatment. A patient is screened to determine if focused ultrasound treatment is appropriate for the patient to treat a disorder. The patient is monitored to measure a plurality of wellness-related parameters for the patient and detect or predict an onset of symptoms associated with the disorder from the wellness-related parameters if focused ultrasound treatment has been determined to be appropriate. A personalized location for focused ultrasound treatment is determined for the patient according to at least one of the wellness-related parameters. At least one parameter associated with the focused ultrasound treatment is selected according to at least one of the wellness-related parameters. Focused ultrasound treatment is provided to the patient at the selected location using the selected at least one parameter. The p wellness-related parameters are measured after focused ultrasound treatment is provided to determine an effectiveness of the treatment.
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公开(公告)号：US20240306974A1
公开(公告)日：2024-09-19
申请号：US18571127
申请日：2022-06-16
发明人： Partho SENGUPTA , Naveena YANAMALA
CPC分类号： A61B5/341 , A61B5/0006 , A61B5/256 , A61B5/6804 , A61B5/7264 , A61B2562/222
摘要： Various examples are provided related to synthetic echocardiography. In one example, a method includes receiving surface electrocardiography (ECG) signals obtained from a patient; synthesizing, through a machine learning model, a 3D model of a heart based upon the surface ECG signals; and generating a rendering of the heart based upon the synthesized model of the heart. In another example, a system includes a wearable monitoring device that can collect and transmit surface ECG signals; and a computing device that can receive the surface ECG signals obtained from a patient using the wearable monitoring device; synthesize, through a machine learning model, a 3D model of a heart based upon the surface ECG signals; and generate a rendering of the heart based upon the synthesized model of the heart. The rendering of the heart can be displayed locally (e.g., by the computing device) or transmitted to a user device for display.
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公开(公告)号：US20240302462A1
公开(公告)日：2024-09-12
申请号：US18573673
申请日：2022-06-24
发明人： Mark Tseytlin , Oxana Tseytlin , Ryan O’Connell
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/60 , H03J3/32
摘要： Various examples are provided related to bimodal electron paramagnetic resonance (EPR). In one example, a bimodal resonator includes a detection coil; first and second excitation coils, where the excitation coils are non-parallel separated by a fixed angle; and excitation controllers coupled to the first and second excitation coils. The excitation controllers can adjust radio frequency (RF) fields generated by the first and second excitation coils to produce a resonator field substantially parallel with the detection coil. In another example, a method including generating a first RF field by exciting the first excitation coil; generating a second RF field by exciting the second excitation coil; and producing a resonator field substantially parallel with a detection coil of the bimodal resonator by adjusting the RE field of the first excitation coil, the RF filed of the second excitation coil, or both.
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4.发明公开公开(公告)号：US20240230680A9
公开(公告)日：2024-07-11
申请号：US18383386
申请日：2023-10-24
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61N2007/0026 , A61N2007/0039
摘要： A method of improving a neurodegenerative or cognitive disorder in a human patient suffering therefrom is provided by determining a target site of the human patient's brain that is affected by the neurodegenerative disorder or cognitive disorder and providing a therapy to the human patient. The therapy includes applying a low intensity focused ultrasound (LiFUS) sonication via an ultrasound delivery device to the target site based on an imaging parameter, a microbubble cavitation; an optical parameter, a bodily fluid parameter, or a physiological or anatomical parameter of the human patient's brain. A therapeutic agent is introduced to the target site before, after or during application of the LiFUS sonication.
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公开(公告)号：US20240199525A1
公开(公告)日：2024-06-20
申请号：US18511496
申请日：2023-11-16
发明人： Yehenew Agazie
摘要： The present invention provides a compound of the formula:
wherein R1 is a hydrogen or a COOH, R2 is a hydrogen or a COOH, R3 is a hydrogen or a COOH, R4 is one selected from the group consisting of H, COOH, and CH2COOH, and R5 is one selected from the group consisting of H, COOH, and CH2COOH. The present invention provides a compound having the formula:
wherein R is COOH or CH2COOH. Pharmaceutical compositions comprising one of these compounds and at least one of an acceptable pharmaceutical carrier, are provided. Methods of treating a patient having cancer are provided.-
公开(公告)号：US20240174526A1
公开(公告)日：2024-05-30
申请号：US18284525
申请日：2022-03-27
发明人： Jianli HU , Yuxin WANG , Dushyant SHEKHAWAT , Christina WILDFIRE , Alexander David WELSH , Robert Edward WEISS
CPC分类号： C01C1/0411 , B01J3/04 , B01J23/10 , B01J23/462 , B01J23/58 , B01J37/346
摘要： The disclosure relates to relates to heterogeneous catalysts useful for the synthesis of ammonia under electromagnetic irradiation, processes for preparing the disclosed heterogeneous catalysts, processes for synthesizing ammonia at ambient pressures using hydrogen and nitrogen. The disclosed heterogeneous catalysts can be utilized in disclosed processes for efficient synthesis of ammonia utilizing a variable frequency reactor with an electromagnetic frequency generator and a reactor chamber. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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7.发明公开公开(公告)号：US20240158235A1
公开(公告)日：2024-05-16
申请号：US18240325
申请日：2023-08-30
发明人： Jianli HU , Sonit BALYAN , Changle JIANG
CPC分类号： C01B32/15 , C01B3/26 , C01B2202/34 , C01B2203/0277 , C01B2203/1058 , C01B2203/1082 , C01B2203/1088 , C01B2203/1235 , C01P2002/82 , C01P2002/88 , C01P2004/04
摘要： In one aspect, the disclosure relates to compositions, processes, and devices for conversion of acetylene to hydrogen and carbon nanomaterials. In a further aspect, the disclosed methods comprise microwave irradiation of a feed stream comprising acetylene in the presence of a catalyst. Also disclosed are compositions produced by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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8.发明公开公开(公告)号：US20240142472A1
公开(公告)日：2024-05-02
申请号：US18383393
申请日：2023-10-24
CPC分类号： G01N33/6896 , G01N29/34 , G01N33/53 , G01N2800/28
摘要： A method of improving a neurodegenerative or cognitive disorder in a human patient suffering therefrom is provided by determining a target site of the human patient's brain that is affected by the neurodegenerative disorder or cognitive disorder and providing a therapy to the human patient. The therapy includes applying a low intensity focused ultrasound (LiFUS) sonication via an ultrasound delivery device to the target site based on an imaging parameter, a microbubble cavitation; an optical parameter, a bodily fluid parameter, or a physiological or anatomical parameter of the human patient's brain. A therapeutic agent is introduced to the target site before, after or during application of the LiFUS sonication.
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公开(公告)号：US20240082023A1
公开(公告)日：2024-03-14
申请号：US18357999
申请日：2023-07-24
CPC分类号： A61F2/72 , A61B5/1107 , A61B5/4519 , A61F2/582 , A61F2/70 , B25J9/1075 , G06F3/011 , G06F3/015 , G16H30/20 , A61F2002/6827
摘要： An approximation method and system are provided for more quickly controlling a prosthetic or other device by reducing computational processing time in a muscle model that can be used to control the prosthetic. For a given muscle, the approximation method can quickly compute polynomial structures for a muscle length and for each associated moment arms, which may be used to generate a torque for a joint position of a physics model. The physics model, in turn, produces a next joint position and velocity data for driving a prosthetic. The approximation method expands the polynomial structures as long as expansion is possible and sufficiently beneficial. The computations can be performed quickly by expanding the polynomial structures in a way that constrains the muscle length polynomial to the moment arm polynomial structures, and vice versa.
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公开(公告)号：US20240058283A1
公开(公告)日：2024-02-22
申请号：US18336712
申请日：2023-06-16
申请人： West Virginia University Board of Governors on Behalf of West Virginia University , Temple University-Of the Commonwealth System of Higher Education , University of Pittsburgh-Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
IPC分类号： A61K31/167
CPC分类号： A61K31/167
摘要： A method of restoring the balance of osteoclast to osteoblast activity in a patient having rheumatoid arthritis comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. A method for treating arthritis-induced bone erosion in a patient comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. The compound N-(3,4-dichlorophenyl)-N-methylpropanamide is administered in a pharmaceutically acceptable composition to said patient. A mode of action of N-(3,4-dichlorophenyl)-N-methyl propanamide comprising targeting transient receptor potential channels is provided.
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