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公开(公告)号：US10067130B2
公开(公告)日：2018-09-04
申请号：US14978413
申请日：2015-12-22
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Xiang-Jin Meng , Yaowei Huang
IPC: G01N33/569 , A61K39/12 , C12Q1/70 , C12N15/86 , C12N7/00 , C07K14/005 , A61K39/00
Abstract: The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of Torque teno sus virus (TTsuV). The present invention also provides methods for diagnosing TTsuV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies which indicate infections TTsuV1, TTsuV2, and individual TTsuV1 genotypes.
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公开(公告)号：US09897605B2
公开(公告)日：2018-02-20
申请号：US14946384
申请日：2015-11-19
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Xiang-Jin Meng , Yaowei Huang
IPC: G01N33/569 , C07K16/08 , C12Q1/70 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
Abstract: The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
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公开(公告)号：US09855327B2
公开(公告)日：2018-01-02
申请号：US15445084
申请日：2017-02-28
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Xiang-Jin Meng , Nathan M. Beach , Sheela Ramamoorthy
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10062
Abstract: The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).
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Patent Agency Ranking
4.发明公开公开(公告)号：US20240261394A1
公开(公告)日：2024-08-08
申请号：US17924963
申请日：2021-05-11
Inventor： Steven L. Zeichner , Xiang-Jin Meng , Debin Tian
CPC classification number: A61K39/225 , A61P31/14 , C12N1/205 , C12N7/00 , A61K2039/522 , A61K2039/523 , C12N2770/00034 , C12R2001/19
Abstract: Provided are modified bacteria and derivatives thereof that express nucleotide sequence encoding an antigen of a viral family selected from the group comprising Retroviridae (e.g., HIV, including a HIV Fusion Peptide antigen), Orthomyxoviridae, Paramyxoviridae, Arenaviridae, 5 Filoviridae, and/or Coronaviridae (e.g., an SARS-CoV, SARS-CoV-2 Fusion Peptide, and/or PEDV). In some embodiments, the bacterium has a reduced genome and induces an enhanced immune response against the viral antigen of interest when administered to a subject. In some embodiments, the viral (e.g., SARS-CoV, 10 SARS-CoV-2, PEDV, and/or HIV) antigen is expressed on a surface of a bacterium. Also provided are method for producing antibodies against viral antigens, vaccine compositions, methods for vaccinating subjects, methods for treating viral infections in subjects, and expression vectors for expressing viral antigens including but not limited to coronavirus (e.g., SARS-CoV, SARS-CoV-2, and/or PEDV) antigens and/or HIV antigens on the surface of reduced 15 genome bacteria.
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公开(公告)号：US09610344B2
公开(公告)日：2017-04-04
申请号：US14174635
申请日：2014-02-06
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Xiang-Jin Meng , Nathan M. Beach , Sheela Ramamoorthy
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10062
Abstract: The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).
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公开(公告)号：US20190091320A1
公开(公告)日：2019-03-28
申请号：US16082168
申请日：2017-03-03
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Xiang-Jin Meng , Shannon R. Matzinger , Nathan M. Beach
Abstract: Vaccine compositions and methods are described for providing immunity to porcine circovirus type two (PCV2) genotypes including by administration of a recombinant PCV2 capsid polypeptide which comprises antigenic epitopes from the capsids of multiple PCV2 genotypes. In other embodiments a recombinant chimeric porcine circovirus is provides for use as a vaccine that combines the nonpathogenic backbone of porcine circovirus type 1 (PCV1) with the sequences encoding a PCV2 capsid polypeptide comprises antigenic epitopes from the capsids of multiple PCV2 genotypes.
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公开(公告)号：US20160266116A1
公开(公告)日：2016-09-15
申请号：US14978413
申请日：2015-12-22
Applicant: Virginia Tech Intellectual Properties
Inventor： Xiang-Jin Meng , Yaowei Huang
IPC: G01N33/569 , C12N7/00 , A61K39/12
CPC classification number: G01N33/56983 , A61K39/12 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/00043 , C12Q1/701 , G01N2333/01 , G01N2469/20
Abstract: The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of Torque teno sus virus (TTsuV). The present invention also provides methods for diagnosing TTsuV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies which indicate infections TTsuV1, TTsuV2, and individual TTsuV1 genotypes.
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8.发明授权Infectious genomic DNA clone and serological profile of Torque teno sus virus 1 and 2 有权传染性基因组DNA克隆和扭矩腱sus病毒1和2的血清学特征公开(公告)号：US09249192B2
公开(公告)日：2016-02-02
申请号：US13840805
申请日：2013-03-15
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Xiang-Jin Meng , Yaowei Huang
IPC: C07K14/005 , C12N7/00 , C12N15/86 , A61K39/12 , G01N33/569 , C12Q1/70 , A61K39/00
CPC classification number: G01N33/56983 , A61K39/12 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/00043 , C12Q1/701 , G01N2333/01 , G01N2469/20
Abstract: The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of Torque teno sus virus (TTsuV). The present invention also provides methods for diagnosing TTsuV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies which indicate infections TTsuV1, TTsuV2, and individual TTsuV1 genotypes.
Abstract translation: 本发明还提供感染性DNA克隆，含有Torque teno sus病毒（TTsuV）的感染性核酸基因组分子的生物功能质粒或病毒载体。 本发明还提供了通过免疫学方法例如酶联免疫吸附测定（ELISA）和使用PTTV特异性抗原检测表明感染TTsuV1，TTsuV2和个体TTsuV1基因型的血清PTTV特异性抗体的蛋白质印迹来诊断TTsuV感染的方法。
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