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1.发明申请COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE 有权化合物作为INDOLEAMINE 2,3-DIOXYGENASE的抑制剂有用公开(公告)号：US20150336903A1
公开(公告)日：2015-11-26
申请号：US14722413
申请日：2015-05-27
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Boyall , Christopher Davis , James Dodd , Simon Everitt , Andrew Miller , Peter Weber , James Westcott , Stephen Young , Luca Settimo
IPC: C07D249/04 , A61K31/4439 , C07D401/12 , A61K31/4192 , A61K45/06
CPC classification number: C07D249/04 , A61K31/4192 , A61K31/4439 , A61K45/06 , C07D249/10 , C07D401/12 , C07D403/12 , C07D413/12
Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications.The compounds of this invention have formula I-A: wherein the variables are as defined herein.
Abstract translation: 本发明涉及可用作吲哚胺2,3-双加氧酶（IDO）抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用该化合物的方法。 本发明的化合物具有式I-A：其中变量如本文所定义。
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公开(公告)号：US09499497B2
公开(公告)日：2016-11-22
申请号：US14722413
申请日：2015-05-27
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Boyall , Christopher Davis , James Dodd , Simon Everitt , Andrew Miller , Peter Weber , James Westcott , Stephen Young , Luca Settimo
IPC: C07D249/04 , C07D401/12 , A61K31/4192 , A61K45/06 , A61K31/4439 , C07D403/12 , C07D413/12 , C07D249/10
CPC classification number: C07D249/04 , A61K31/4192 , A61K31/4439 , A61K45/06 , C07D249/10 , C07D401/12 , C07D403/12 , C07D413/12
Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications.The compounds of this invention have formula I-A: wherein the variables are as defined herein.
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公开(公告)号：US20130252939A1
公开(公告)日：2013-09-26
申请号：US13873591
申请日：2013-04-30
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US09073875B2
公开(公告)日：2015-07-07
申请号：US14083693
申请日：2013-11-19
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Boyall , Christopher Davis , James Dodd , Simon Everitt , Andrew Miller , Peter Weber , James Westcott , Stephen Young , Luca Settimo
IPC: C07D249/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D249/10
CPC classification number: C07D249/04 , A61K31/4192 , A61K31/4439 , A61K45/06 , C07D249/10 , C07D401/12 , C07D403/12 , C07D413/12
Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications. The compounds of this invention have formula I-A: wherein the variables are as defined herein.
Abstract translation: 本发明涉及可用作吲哚胺2,3-双加氧酶（IDO）抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用该化合物的方法。 本发明的化合物具有式I-A：其中变量如本文所定义。
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公开(公告)号：US08815866B2
公开(公告)日：2014-08-26
申请号：US13737173
申请日：2013-01-09
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC: A61K31/497 , C07D401/00
CPC classification number: C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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Patent Agency Ranking
公开(公告)号：US20140148434A1
公开(公告)日：2014-05-29
申请号：US14030153
申请日：2013-09-18
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Dean Boyall , Guy Brenchley , Damien Fraysse , Juan-Miguel Jimenez , Luca Settimo
IPC: C07D471/04
CPC classification number: A01K39/01 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20130137703A1
公开(公告)日：2013-05-30
申请号：US13737173
申请日：2013-01-09
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Francois Maltais , Guy W. Bemis , Tiansheng Wang , Juan-Miguel Jimenez , Luca Settimo , Stephen Young , Dean Boyall , Damien Fraysse , Christopher John Davis
IPC: C07D417/14 , C07D401/14 , C07D401/10
CPC classification number: C07D417/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D407/04 , C07D407/12
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US09193722B2
公开(公告)日：2015-11-24
申请号：US13873591
申请日：2013-04-30
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC: C07D239/24 , C07D241/10 , A61K31/496 , A61K31/506 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. The compounds of the present invention are represented by the structure of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。 本发明的化合物由式I的结构或其药学上可接受的盐表示，其中变量在本文中定义。
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公开(公告)号：US09029546B2
公开(公告)日：2015-05-12
申请号：US14030153
申请日：2013-09-18
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Boyall , Guy Brenchley , Damien Fraysse , Juan-Miguel Jimenez , Luca Settimo
IPC: C07D515/02 , A61K31/44 , C07D471/04 , C07D519/00
CPC classification number: A01K39/01 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20140221334A1
公开(公告)日：2014-08-07
申请号：US14249614
申请日：2014-04-10
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
IPC: C07D213/73 , C07D401/12 , C07D401/04
CPC classification number: C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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