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公开(公告)号：US20190256516A1
公开(公告)日：2019-08-22
申请号：US16192134
申请日：2018-11-15
发明人： Jean-Damien Charrier , Christopher John Davis , Damien Fraysse , Gorka Etxebarria I Jardi , Simon Pegg , Francoise Pierard , Joanne Pinder , John Studley , Carl Zwicker , Tapan Sanghvi , Michael Waldo , Ales Medek , David Matthew Shaw , Maninder Panesar , Yuegang Zhang , Naziha Alem
IPC分类号： C07D487/04 , C07B59/00 , C07C45/63 , C07C45/00
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.
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公开(公告)号：US20180155346A1
公开(公告)日：2018-06-07
申请号：US15633477
申请日：2017-06-26
发明人： Nadia Ahmad , Dean Boyall , Jean-Damien Charrier , Christopher John Davis , Rebecca Davis , Steven John Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Marcellus Alphonsus Knegtel , Donald Middleton , Michael Edward O'Donnell , Maninder Panesar , Francoise Yvonne Theodora Marie Pierard , Joanne Pinder , David Matthew Shaw , Pierre-Henri Storck , John R. Studley , Heather Twin
IPC分类号： C07D487/04 , C07D498/10 , C07D498/04 , C07D453/02 , C07D487/08 , C07D471/08 , C07D491/107
CPC分类号： C07D487/04 , C07D453/02 , C07D471/08 , C07D487/08 , C07D491/107 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein.Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
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公开(公告)号：US20160326180A1
公开(公告)日：2016-11-10
申请号：US15144921
申请日：2016-05-03
发明人： Dean Boyall , Jean-Damien Charrier , Christopher John Davis , Steven John Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , David Kay , Ronald Marcellus Alphonsus Knegtel , Joanne Pinder
IPC分类号： C07D487/04 , A61N5/10 , C07D471/04 , A61K31/437 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/437 , A61K31/5025 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention are represented by formula I-A and formula I-B: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
摘要翻译： 或其药学上可接受的盐，其中变量如本文所定义。
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公开(公告)号：US11485739B2
公开(公告)日：2022-11-01
申请号：US16994968
申请日：2020-08-17
发明人： Jean-Damien Charrier , Christopher John Davis , Damien Fraysse , Gorka Etxebarria I Jardi , Simon Pegg , Francoise Pierard , Joanne Pinder , John Studley , Carl Zwicker , Tapan Sanghvi , Michael Waldo , Ales Medek , David Matthew Shaw , Maninder Panesar , Yuegang Zhang , Naziha Alem
IPC分类号： C07D487/04 , C07C45/00 , C07C45/63 , C07B59/00 , A61K31/519
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.-
公开(公告)号：US10160760B2
公开(公告)日：2018-12-25
申请号：US14561368
申请日：2014-12-05
发明人： Jean-Damien Charrier , Christopher John Davis , Damien Fraysse , Gorka Etxebarria I Jardi , Simon Pegg , Francoise Pierard , Joanne Pinder , John Studley , Carl Zwicker , Tapan Sanghvi , Michael Waldo , Ales Medek , David Matthew Shaw , Maninder Panesar , Yuegang Zhang , Naziha Alem
IPC分类号： C07D487/04 , A61K31/519 , C07C45/00 , C07C45/63 , C07B59/00 , A61P35/00
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.
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公开(公告)号：US08765751B2
公开(公告)日：2014-07-01
申请号：US13631730
申请日：2012-09-28
IPC分类号： A61K31/535 , A61K31/5377 , C07D413/14 , C07D413/04 , C07D413/10
CPC分类号： A61K31/5377 , A61K33/24 , C07D265/30 , C07D267/10 , C07D401/04 , C07D413/04 , C07D413/10 , C07D413/14
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein. Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates.
摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。 此外，本发明还涉及用于生产各种基于morpoholine的中间体的新方法。
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公开(公告)号：US20130252939A1
公开(公告)日：2013-09-26
申请号：US13873591
申请日：2013-04-30
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US09193722B2
公开(公告)日：2015-11-24
申请号：US13873591
申请日：2013-04-30
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： C07D239/24 , C07D241/10 , A61K31/496 , A61K31/506 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. The compounds of the present invention are represented by the structure of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。 本发明的化合物由式I的结构或其药学上可接受的盐表示，其中变量在本文中定义。
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公开(公告)号：US20140221334A1
公开(公告)日：2014-08-07
申请号：US14249614
申请日：2014-04-10
发明人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
IPC分类号： C07D213/73 , C07D401/12 , C07D401/04
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US10815239B2
公开(公告)日：2020-10-27
申请号：US16192134
申请日：2018-11-15
发明人： Jean-Damien Charrier , Christopher John Davis , Damien Fraysse , Gorka Etxebarria I Jardi , Simon Pegg , Francoise Pierard , Joanne Pinder , John Studley , Carl Zwicker , Tapan Sanghvi , Michael Waldo , Ales Medek , David Matthew Shaw , Maninder Panesar , Yuegang Zhang , Naziha Alem
IPC分类号： C07D487/04 , A61K31/519 , C07B59/00 , C07C45/00 , C07C45/63
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.
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