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公开(公告)号：US20150038535A1
公开(公告)日：2015-02-05
申请号：US14474887
申请日：2014-09-02
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily
IPC: C07D409/04
CPC classification number: C07D409/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20130310418A1
公开(公告)日：2013-11-21
申请号：US13868123
申请日：2013-04-23
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![5-cyano-4- (pyrrolo [2,3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors](/abs-image/US/2015/02/24/US08962642B2/abs.jpg.150x150.jpg)
3.发明授权5-cyano-4- (pyrrolo [2,3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors 有权可用作蛋白激酶抑制剂的5-氰基-4-（吡咯并[2,3B]吡啶-3-基） - 嘧啶衍生物公开(公告)号：US08962642B2
公开(公告)日：2015-02-24
申请号：US13961218
申请日：2013-08-07
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC: A01N43/54 , A61K31/505 , C07D471/04
CPC classification number: C07D471/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US09193722B2
公开(公告)日：2015-11-24
申请号：US13873591
申请日：2013-04-30
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC: C07D239/24 , C07D241/10 , A61K31/496 , A61K31/506 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. The compounds of the present invention are represented by the structure of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。 本发明的化合物由式I的结构或其药学上可接受的盐表示，其中变量在本文中定义。
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公开(公告)号：US09029546B2
公开(公告)日：2015-05-12
申请号：US14030153
申请日：2013-09-18
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Boyall , Guy Brenchley , Damien Fraysse , Juan-Miguel Jimenez , Luca Settimo
IPC: C07D515/02 , A61K31/44 , C07D471/04 , C07D519/00
CPC classification number: A01K39/01 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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Patent Agency Ranking
公开(公告)号：US20130310433A1
公开(公告)日：2013-11-21
申请号：US13911110
申请日：2013-06-06
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily
IPC: C07D409/04 , C12N9/99 , C07D409/14 , A61K31/4196 , A61K45/06
CPC classification number: C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US20150291601A1
公开(公告)日：2015-10-15
申请号：US14600214
申请日：2015-01-20
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Guy Brenchley , Jean-Damien Charrier , Chris Davis , Steven Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Knegtel , Francoise Pierard , Joanne Pinder , David Shaw , Pierre-Henri Storck , John Studley , Heather Twin
IPC: C07D487/04 , A61K31/519 , C07D519/00 , A61K31/5377 , A61N5/10 , A61K33/24 , A61K31/7068 , A61K31/36 , A61K31/4188 , C12N9/12 , A61K45/06 , A61K31/551
CPC classification number: C07D487/04 , A61K31/36 , A61K31/4188 , A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/7068 , A61K33/24 , A61K45/06 , A61N5/1028 , A61N5/1077 , A61N2005/1087 , A61N2005/1089 , A61N2005/109 , C07D453/02 , C07D471/08 , C07D491/107 , C07D519/00 , C12N9/12 , C12Y207/11001
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：或其药学上可接受的盐，其中变量如本文所定义。
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公开(公告)号：US08957078B2
公开(公告)日：2015-02-17
申请号：US14098640
申请日：2013-12-06
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Guy Brenchley , Jean-Damien Charrier , Chris Davis , Steven Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Knegtel , Francoise Pierard , Joanne Pinder , David Shaw , Pierre-Henri Storck , John Studley , Heather Twin
IPC: C07D487/04 , A61K31/437 , C07D453/02 , C07D471/08 , C07D491/107
CPC classification number: C07D487/04 , A61K31/36 , A61K31/4188 , A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/7068 , A61K33/24 , A61K45/06 , A61N5/1028 , A61N5/1077 , A61N2005/1087 , A61N2005/1089 , A61N2005/109 , C07D453/02 , C07D471/08 , C07D491/107 , C07D519/00 , C12N9/12 , C12Y207/11001
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：或其药学上可接受的盐，其中变量如本文所定义。
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公开(公告)号：US20140148434A1
公开(公告)日：2014-05-29
申请号：US14030153
申请日：2013-09-18
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Dean Boyall , Guy Brenchley , Damien Fraysse , Juan-Miguel Jimenez , Luca Settimo
IPC: C07D471/04
CPC classification number: A01K39/01 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20140275009A1
公开(公告)日：2014-09-18
申请号：US14098640
申请日：2013-12-06
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Guy Brenchley , Jean-Damien Charrier , Chris Davis , Steven Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Knegtel , Francoise Pierard , Joanne Pinder , David Shaw , Pierre-Henri Storck , John Studley , Heather Twin
IPC: C07D487/04 , C07D471/08 , C07D453/02 , C07D491/107
CPC classification number: C07D487/04 , A61K31/36 , A61K31/4188 , A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/7068 , A61K33/24 , A61K45/06 , A61N5/1028 , A61N5/1077 , A61N2005/1087 , A61N2005/1089 , A61N2005/109 , C07D453/02 , C07D471/08 , C07D491/107 , C07D519/00 , C12N9/12 , C12Y207/11001
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
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