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公开(公告)号：US20180162842A1
公开(公告)日：2018-06-14
申请号：US15659926
申请日：2017-07-26
发明人： Sara S. HADIDA RUAH , Peter D.J. GROOTENHUIS , Fredrick VAN GOOR , Jinglan ZHOU , Brian BEAR , Mark T. MILLER , Jason McCARTNEY , Mehdi Michel Jamel NUMA , Xiaoqing YANG
IPC分类号： C07D405/12 , C07D487/04 , C07B59/00 , G01N33/68 , G01N33/50 , C07D403/12 , C07D471/04 , C07D405/14
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20160332997A1
公开(公告)日：2016-11-17
申请号：US15162887
申请日：2016-05-24
发明人： Sara S. HADIDA RUAH , Peter D.J. GROOTENHUIS , Fredrick VAN GOOR , Jinglan ZHOU , Brian BEAR , Mark T. MILLER , Jason McCARTNEY , Mehdi Michel Jamel NUMA , Xiaoqing YANG
IPC分类号： C07D405/12 , C07D405/14 , C07B59/00 , C07D487/04
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20210024505A1
公开(公告)日：2021-01-28
申请号：US16789945
申请日：2020-02-13
IPC分类号： C07D405/12 , C07D317/12 , A61K31/443 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D405/14 , A61K31/47
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20180282311A9
公开(公告)日：2018-10-04
申请号：US15170263
申请日：2016-06-01
发明人： Sara S. HADIDA RUAH , Matthew M. Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： C07D405/12
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20170107205A1
公开(公告)日：2017-04-20
申请号：US15170263
申请日：2016-06-01
发明人： Sara S. HADIDA RUAH , Matthew M. Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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6.发明公开公开(公告)号：US20240294512A1
公开(公告)日：2024-09-05
申请号：US18566305
申请日：2022-06-03
发明人： Elizabeth Mary BECK , Robert PULLIN , Gorka ETXEBARRIA JARDI , Dean STAMOS , Yvonne SCHMIDT , Joseph PONTILLO , Stephen Andrew THOMSON , David Matthew SHAW , Nadia M. AHMAD , Lidio Marx CARVALHO MEIRELES , Sarah SKERRATT , Sara S. HADIDA RUAH , Timothy Donald NEUBERT , Dennis James HURLEY , Steven John DURRANT , Christopher WRAY , Anisa Nizarali VIRANI , Kiri NORTH , Bhairavi GALAN , Ronald Marcellus KNEGTEL , Ewa Iwona CHUDYK , Joanne Louise PINDER , Bruno Artur SOUSA , Francoise PIERARD
IPC分类号： C07D405/12 , A61K31/443 , A61K31/501
CPC分类号： C07D405/12 , A61K31/443 , A61K31/501
摘要： Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：US20220153729A1
公开(公告)日：2022-05-19
申请号：US17362597
申请日：2021-06-29
IPC分类号： C07D405/12 , C07D317/12 , A61K31/443 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D405/14 , A61K31/47
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20170107206A1
公开(公告)日：2017-04-20
申请号：US15173325
申请日：2016-06-03
发明人： Sara S. HADIDA RUAH , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20240092766A1
公开(公告)日：2024-03-21
申请号：US18108053
申请日：2023-02-10
发明人： Sara S. HADIDA RUAH , Peter D.J. GROOTENHUIS , Fredrick VAN GOOR , Jinglan ZHOU , Brian BEAR , Mark T. MILLER , Jason McCARTNEY , Mehdi Michel Jamel NUMA , Xiaoqing YANG
IPC分类号： C07D405/12 , C07D471/04 , A61K31/445 , A61K31/496 , A61K31/5377 , C07D405/14 , C07D403/12 , G01N33/50 , G01N33/68 , C07B59/00 , C07D487/04
CPC分类号： C07D405/12 , C07D471/04 , A61K31/445 , A61K31/496 , A61K31/5377 , C07D405/14 , C07D403/12 , G01N33/5008 , G01N33/6872 , C07B59/002 , C07D487/04 , G01N2333/705 , G01N2500/02 , G01N2500/10 , C07B2200/05
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20220411410A1
公开(公告)日：2022-12-29
申请号：US17181931
申请日：2021-02-22
发明人： Sara S. HADIDA RUAH , Peter D.J. GROOTENHUIS , Fredrick VAN GOOR , Jinglan Zhou , Brian BEAR , Mark T. MILLER , Jason McCARTNEY , Mehdi Michel Jamel NUMA , Xiaoqing YANG
IPC分类号： C07D405/12 , C07D471/04 , A61K31/445 , A61K31/496 , A61K31/5377 , C07D405/14 , C07D403/12 , G01N33/50 , G01N33/68 , C07B59/00 , C07D487/04
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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