专利检索 ap:("VERTEX PHARMACEUTICALS INCORPORATED") AND inv:"Joanne Louise PINDER" 第 1 页

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发明公开
HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS 审中-公开

公开(公告)号：US20240294512A1

公开(公告)日：2024-09-05

申请号：US18566305

申请日：2022-06-03

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Elizabeth Mary BECK , Robert PULLIN , Gorka ETXEBARRIA JARDI , Dean STAMOS , Yvonne SCHMIDT , Joseph PONTILLO , Stephen Andrew THOMSON , David Matthew SHAW , Nadia M. AHMAD , Lidio Marx CARVALHO MEIRELES , Sarah SKERRATT , Sara S. HADIDA RUAH , Timothy Donald NEUBERT , Dennis James HURLEY , Steven John DURRANT , Christopher WRAY , Anisa Nizarali VIRANI , Kiri NORTH , Bhairavi GALAN , Ronald Marcellus KNEGTEL , Ewa Iwona CHUDYK , Joanne Louise PINDER , Bruno Artur SOUSA , Francoise PIERARD

IPC分类号： C07D405/12 , A61K31/443 , A61K31/501

CPC分类号： C07D405/12 , A61K31/443 , A61K31/501

摘要： Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.