公开(公告)号：US20240400544A1

公开(公告)日：2024-12-05

申请号：US18566282

申请日：2022-06-03

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Elizabeth Mary BECK ,  Robert PULLIN ,  Gorka ETXEBARRIA JARDI ,  Dean STAMOS ,  Yvonne SCHMIDT ,  Joseph PONTILLO ,  Stephen Andrew THOMSON ,  David Matthew SHAW ,  Nadia M. AHMAD ,  Lidio Marx CARVALHO MEIRELES ,  Sarah SKERRATT ,  Sara S. HADIDA RUAH ,  Timothy Donald NEUBERT ,  Dennis James HURLEY ,  Alexander KINTZER ,  Steven John DURRANT ,  Christopher WRAY ,  Anisa Nizarali VIRANI ,  Kiri NORTH ,  Reece JACQUES ,  Mark Thomas Miller ,  Jinglan ZHOU ,  Ronald Marcellus KNEGTEL ,  Ewa Iwona CHUDYK ,  Joanne Louise PINDER ,  Bruno Artur SOUSA ,  James DODD ,  Michael Edward O'DONNELL ,  Bhairavi GALAN ,  Rebecca E. STEVENS

IPC: C07D413/14 ,  A61K31/4355 ,  A61K31/443 ,  A61K31/506 ,  A61K31/5377 ,  C07D405/12 ,  C07D405/14 ,  C07D491/04

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20240368135A1

公开(公告)日：2024-11-07

申请号：US18566297

申请日：2022-06-03

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Elizabeth Mary BECK ,  Robert PULLIN ,  Gorka ETXEBARRIA JARDI ,  Dean STAMOS ,  Yvonne SCHMIDT ,  Joseph PONTILLO ,  Stephen Andrew THOMSON ,  David Matthew SHAW ,  Nadia M. AHMAD ,  Lidio Marx CARVALHO MEIRELES ,  Sarah SKERRATT ,  Sara S. HADIDA RUAH ,  Mark Thomas Miller ,  Timothy Donald NEUBERT ,  Dennis James HURLEY ,  Jinglan ZHOU ,  Alexander KINTZER ,  Steven John DURRANT ,  Christopher WRAY ,  Anisa Nizarali VIRANI ,  Kiri NORTH ,  James DODD ,  Reece JACQUES ,  Stephen Michael GEDDIS ,  Bhairavi GALAN ,  Ronald Marcellus KNEGTEL ,  Ewa Iwona CHUDYK ,  Joanne Louise PINDER ,  Bruno Artur SOUSA ,  Rebecca E. STEVENS ,  Miranda Adele WRIGHT ,  Heather Clare TWIN ,  James Jun Bon MUI

IPC: C07D405/12 ,  A61K31/341 ,  A61K31/351 ,  A61K31/38 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551 ,  A61K31/665 ,  C07D307/24 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08 ,  C07F9/655

Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20240294512A1

公开(公告)日：2024-09-05

申请号：US18566305

申请日：2022-06-03

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Elizabeth Mary BECK ,  Robert PULLIN ,  Gorka ETXEBARRIA JARDI ,  Dean STAMOS ,  Yvonne SCHMIDT ,  Joseph PONTILLO ,  Stephen Andrew THOMSON ,  David Matthew SHAW ,  Nadia M. AHMAD ,  Lidio Marx CARVALHO MEIRELES ,  Sarah SKERRATT ,  Sara S. HADIDA RUAH ,  Timothy Donald NEUBERT ,  Dennis James HURLEY ,  Steven John DURRANT ,  Christopher WRAY ,  Anisa Nizarali VIRANI ,  Kiri NORTH ,  Bhairavi GALAN ,  Ronald Marcellus KNEGTEL ,  Ewa Iwona CHUDYK ,  Joanne Louise PINDER ,  Bruno Artur SOUSA ,  Francoise PIERARD

IPC: C07D405/12 ,  A61K31/443 ,  A61K31/501

CPC classification number: C07D405/12 ,  A61K31/443 ,  A61K31/501

Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.