公开(公告)号：US20180162842A1

公开(公告)日：2018-06-14

申请号：US15659926

申请日：2017-07-26

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sara S. HADIDA RUAH ,  Peter D.J. GROOTENHUIS ,  Fredrick VAN GOOR ,  Jinglan ZHOU ,  Brian BEAR ,  Mark T. MILLER ,  Jason McCARTNEY ,  Mehdi Michel Jamel NUMA ,  Xiaoqing YANG

IPC分类号： C07D405/12 ,  C07D487/04 ,  C07B59/00 ,  G01N33/68 ,  G01N33/50 ,  C07D403/12 ,  C07D471/04 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07B59/002 ,  C07B2200/05 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  G01N33/5008 ,  G01N33/6872 ,  G01N2333/705 ,  G01N2500/02 ,  G01N2500/10

摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：US20160332997A1

公开(公告)日：2016-11-17

申请号：US15162887

申请日：2016-05-24

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sara S. HADIDA RUAH ,  Peter D.J. GROOTENHUIS ,  Fredrick VAN GOOR ,  Jinglan ZHOU ,  Brian BEAR ,  Mark T. MILLER ,  Jason McCARTNEY ,  Mehdi Michel Jamel NUMA ,  Xiaoqing YANG

IPC分类号： C07D405/12 ,  C07D405/14 ,  C07B59/00 ,  C07D487/04

CPC分类号： C07D405/12 ,  C07B59/002 ,  C07B2200/05 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  G01N33/5008 ,  G01N33/6872 ,  G01N2333/705 ,  G01N2500/02 ,  G01N2500/10

摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：US20240092766A1

公开(公告)日：2024-03-21

申请号：US18108053

申请日：2023-02-10

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sara S. HADIDA RUAH ,  Peter D.J. GROOTENHUIS ,  Fredrick VAN GOOR ,  Jinglan ZHOU ,  Brian BEAR ,  Mark T. MILLER ,  Jason McCARTNEY ,  Mehdi Michel Jamel NUMA ,  Xiaoqing YANG

IPC分类号： C07D405/12 ,  C07D471/04 ,  A61K31/445 ,  A61K31/496 ,  A61K31/5377 ,  C07D405/14 ,  C07D403/12 ,  G01N33/50 ,  G01N33/68 ,  C07B59/00 ,  C07D487/04

CPC分类号： C07D405/12 ,  C07D471/04 ,  A61K31/445 ,  A61K31/496 ,  A61K31/5377 ,  C07D405/14 ,  C07D403/12 ,  G01N33/5008 ,  G01N33/6872 ,  C07B59/002 ,  C07D487/04 ,  G01N2333/705 ,  G01N2500/02 ,  G01N2500/10 ,  C07B2200/05

摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：US20220411410A1

公开(公告)日：2022-12-29

申请号：US17181931

申请日：2021-02-22

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sara S. HADIDA RUAH ,  Peter D.J. GROOTENHUIS ,  Fredrick VAN GOOR ,  Jinglan Zhou ,  Brian BEAR ,  Mark T. MILLER ,  Jason McCARTNEY ,  Mehdi Michel Jamel NUMA ,  Xiaoqing YANG

IPC分类号： C07D405/12 ,  C07D471/04 ,  A61K31/445 ,  A61K31/496 ,  A61K31/5377 ,  C07D405/14 ,  C07D403/12 ,  G01N33/50 ,  G01N33/68 ,  C07B59/00 ,  C07D487/04

摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.