公开(公告)号：US20240342218A1

公开(公告)日：2024-10-17

申请号：US18294700

申请日：2022-08-03

Applicant: University Health Network

Inventor： Michael George FEHLINGS ,  Mohammad KHAZAEI ,  Christopher S. AHUJA

IPC: A61K35/30 ,  A61P25/00 ,  C12N5/0797

CPC classification number: A61K35/30 ,  A61P25/00 ,  C12N5/0623 ,  C12N2501/119 ,  C12N2501/13 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2506/45

Abstract: The present disclosure relates generally to neural progenitor cells and therapeutic uses thereof. More particularly, the present disclosure provides cervical spinal cord-specific neural progenitor cells (cerNPCs), methods of producing cerNPCs, pharmaceutical compositions comprising cerNPCs. and methods of treating neurological diseases or disorders with the cerNPCs.

公开(公告)号：US20240009248A1

公开(公告)日：2024-01-11

申请号：US18044288

申请日：2021-09-08

Applicant: University Health Network

Inventor： Michael G FEHLINGS ,  Mohammad KHAZAEI ,  Christopher S AHUJA

IPC: A61K35/30 ,  C12N5/0793 ,  A61P25/28

CPC classification number: A61K35/30 ,  C12N5/0619 ,  A61P25/28 ,  C12N2506/45 ,  C12N2501/11 ,  C12N2501/42 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/415

Abstract: Provided herein are methods of producing spNPCs from iPSCs or NPCs, cell populations, compositions comprising cell populations, and uses of spNPCs made using the methods described. The method can comprise: a. obtaining unpatterned NPCs, the unpatterned NPCs expressing neuroectodermal markers including Pax6 and Sox1; b. priming the unpatterned NPCs of step a; and c. patterning the primed unpatterned NPCs to produce spNPCS.

公开(公告)号：US20240391967A1

公开(公告)日：2024-11-28

申请号：US18255136

申请日：2021-12-02

Applicant: University Health Network

Inventor： Michael George FEHLINGS ,  Mohammad KHAZAEI

IPC: C07K14/47 ,  A61K38/00 ,  A61P25/28 ,  C07K7/08 ,  C12N15/63 ,  C12N15/85

Abstract: Disclosed herein are methods for treating a neurodegenerative disease and/or an optic nerve, brain and/or spinal cord injury using a Ndfip1 fusion polypeptide, a Ndfip1 nucleic acid molecule, a construct or expression cassette comprising the Ndfip1 nucleic acid molecule, and a cell comprising the construct and/or expression the fusion polypeptide.