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    Aptamer Conjugates with N-Heterocyclic Carbene Metal Complexes for Targeted Drug Delivery
    1.
    发明申请
    Aptamer Conjugates with N-Heterocyclic Carbene Metal Complexes for Targeted Drug Delivery 审中-公开

    公开(公告)号：US20200339993A1

    公开(公告)日：2020-10-29

    申请号：US16925545

    申请日：2020-07-10

    申请人： University of Florida Research Foundation, Inc.

    发明人： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

    IPC分类号： C12N15/115 ,  A61K47/54 ,  A61K31/555

    摘要： An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.

    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery
    3.
    发明授权
    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery 有权

    公开(公告)号：US11912999B2

    公开(公告)日：2024-02-27

    申请号：US16925545

    申请日：2020-07-10

    申请人： University of Florida Research Foundation, Inc.

    发明人： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

    IPC分类号： C12N15/115 ,  A61K47/54 ,  A61K31/555

    CPC分类号： C12N15/115 ,  A61K31/555 ,  A61K47/549 ,  C12N2310/16 ,  C12N2310/351

    摘要： An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.

    Macrocyclic poly(akane)s and poly(alkane-co-alkene)s
    4.
    发明授权
    Macrocyclic poly(akane)s and poly(alkane-co-alkene)s 有权

    公开(公告)号：US11807694B2

    公开(公告)日：2023-11-07

    申请号：US16648159

    申请日：2018-08-24

    申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

    发明人： Adam S. Veige

    IPC分类号： C08F110/06 ,  C08F138/00 ,  C08F110/14 ,  C08G61/08

    CPC分类号： C08F110/06 ,  C08F110/14 ,  C08F138/00 ,  C08G61/08 ,  C08F2500/25 ,  C08G2261/418 ,  C08G2261/419 ,  C08G2261/724

    摘要： Macrocyclic polyalkene homopolymers and copolymers can be formed and converted to macrocyclic polyalkanes or macrocyclic poly(alkane-co-alkene) upon hydrogenation or, when the macrocyclic polyalkene is reacted with an alkene in the presence of an olefin metathesis catalyst, to a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)—'s. Upon hydrogenation of a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)-'s, macrocyclic poly(alkane)s or poly(alkane-co-alkene)s with isolated —C(═CR2)- groups can be provided, depending on the degree of hydrogenation. The poly(alkane-co-alkene)s with isolated —C(═CR2)- units can be used to form poly(macrocyclic poly(alkane-co-alkene))s, poly(macrocyclic poly(alkane))s, and/or bi-, tri-, and/or multi-macrocyclic poly(alkane-co-alkene)s or bi-, tri-, and/or multi-macrocyclic poly(alkane)s.

    Functionalized Cyclic Polymers and Methods of Preparing Same
    5.
    发明申请
    Functionalized Cyclic Polymers and Methods of Preparing Same 有权

    公开(公告)号：US20220056167A1

    公开(公告)日：2022-02-24

    申请号：US17516191

    申请日：2021-11-01

    申请人： University of Florida Research Foundation, Inc.

    发明人： Adam S. Veige

    IPC分类号： C08F4/78

    摘要： The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure.

    MACROCYCLIC POLY(AKANE)S AND POLY(ALKANE-CO-ALKENE)S
    7.
    发明申请
    MACROCYCLIC POLY(AKANE)S AND POLY(ALKANE-CO-ALKENE)S 审中-公开

    公开(公告)号：US20200255560A1

    公开(公告)日：2020-08-13

    申请号：US16648159

    申请日：2018-08-24

    申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

    发明人： Adam S. Veige

    IPC分类号： C08F110/06 ,  C08G61/08 ,  C08F138/00 ,  C08F110/14

    摘要： Macrocyclic polyalkene homopolymers and copolymers can be formed and converted to macrocyclic polyalkanes or macrocyclic poly(alkane-co-alkene) upon hydrogenation or, when the macrocyclic polyalkene is reacted with an alkene in the presence of an olefin metathesis catalyst, to a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)—'s. Upon hydrogenation of a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)-'s, macrocyclic poly(alkane)s or poly(alkane-co-alkene)s with isolated —C(═CR2)- groups can be provided, depending on the degree of hydrogenation. The poly(alkane-co-alkene)s with isolated —C(═CR2)- units can be used to form poly(macrocyclic poly(alkane-co-alkene))s, poly(macrocyclic poly(alkane))s, and/or bi-, tri-, and/or multi-macrocyclic poly(alkane-co-alkene)s or bi-, tri-, and/or multi-macrocyclic poly(alkane)s.

    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery
    8.
    发明授权
    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery 有权

    公开(公告)号：US10731164B2

    公开(公告)日：2020-08-04

    申请号：US15397231

    申请日：2017-01-03

    申请人： University of Florida Research Foundation, Inc.

    发明人： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

    IPC分类号： A61K35/35 ,  C12N5/077 ,  C12N15/115 ,  A61K47/54 ,  A61K31/555

    摘要： An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.

    Functionalized cyclic polymers and methods of preparing same
    9.
    发明授权
    Functionalized cyclic polymers and methods of preparing same 有权

    公开(公告)号：US11814462B2

    公开(公告)日：2023-11-14

    申请号：US17516191

    申请日：2021-11-01

    申请人： University of Florida Research Foundation, Inc.

    发明人： Adam S. Veige

    IPC分类号： C08F4/78 ,  C08F138/00

    CPC分类号： C08F4/78

    摘要： The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure.