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公开(公告)号：US08188229B2
公开(公告)日：2012-05-29
申请号：US13027025
申请日：2011-02-14
IPC分类号： C07K17/00
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译： 本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。 本发明的一个方面是提供独特的机械和物理性质的纤维组分。 本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含 聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。
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公开(公告)号：US20110133368A1
公开(公告)日：2011-06-09
申请号：US13027025
申请日：2011-02-14
IPC分类号： B29C41/04
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译： 本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。 本发明的一个方面是提供独特的机械和物理性质的纤维组分。 本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含 聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。
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公开(公告)号：US20100331865A1
公开(公告)日：2010-12-30
申请号：US12495611
申请日：2009-06-30
IPC分类号： A61B17/08
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/30014 , A61F2002/30028 , A61F2002/30031 , A61F2002/30052 , A61F2002/30088 , A61F2002/30332 , A61F2002/3092 , A61F2002/30971 , A61F2002/4495 , A61F2210/008 , A61F2220/0033 , A61F2250/0018 , A61F2250/0043 , A61F2250/0051 , A61F2250/0056 , A61F2310/00365 , A61L27/24 , A61L27/48 , A61L27/50 , A61L27/52 , A61L27/56 , A61L2430/06
摘要： Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.
摘要翻译： 组织植入物准备用于修复组织，特别是无血管组织如软骨。 一个实施例呈现出当暴露于动态载荷时能够从周围流体接收和积聚期望因子或分子的电势。 在另一个实施方案中，所述植入物通过使用梯度来延缓，限制和控制细胞侵袭直到感染组织形成来促进组织传导。 组织植入物的其它实施方案可以形成为通过在植入物表面经历的机械和流体力的传导而提供深层组织机械刺激的多相装置。
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公开(公告)号：US10016278B2
公开(公告)日：2018-07-10
申请号：US12495611
申请日：2009-06-30
IPC分类号： A61F2/02 , A61F2/28 , A61F2/30 , A61L27/24 , A61L27/48 , A61L27/50 , A61L27/52 , A61L27/56 , A61F2/44
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/30014 , A61F2002/30028 , A61F2002/30031 , A61F2002/30052 , A61F2002/30088 , A61F2002/30332 , A61F2002/3092 , A61F2002/30971 , A61F2002/4495 , A61F2210/008 , A61F2220/0033 , A61F2250/0018 , A61F2250/0043 , A61F2250/0051 , A61F2250/0056 , A61F2310/00365 , A61L27/24 , A61L27/48 , A61L27/50 , A61L27/52 , A61L27/56 , A61L2430/06
摘要： Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.
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公开(公告)号：US08551514B2
公开(公告)日：2013-10-08
申请号：US12316798
申请日：2008-12-15
IPC分类号： A61F2/02
摘要： The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce salvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.
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公开(公告)号：US20090175944A1
公开(公告)日：2009-07-09
申请号：US12316798
申请日：2008-12-15
IPC分类号： A61K9/10
摘要： The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce salvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.
摘要翻译： 本发明涉及多孔聚合物凝胶材料的干燥形式，其可以被再水化并置于压力或压缩下以诱导救济，从而形成可注射的粘性油灰或面团形式的高浓度凝胶，其可以植入在 身体。
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公开(公告)号：US07910690B2
公开(公告)日：2011-03-22
申请号：US11741611
申请日：2007-04-27
IPC分类号： C07K17/00
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译： 本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。 本发明的一个方面是提供独特的机械和物理性质的纤维组分。 本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含 聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。
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公开(公告)号：US07214765B2
公开(公告)日：2007-05-08
申请号：US11178175
申请日：2005-07-08
IPC分类号： C07K17/00
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译： 本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。 本发明的一个方面是提供独特的机械和物理性质的纤维组分。 本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含 聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。
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公开(公告)号：US08633299B2
公开(公告)日：2014-01-21
申请号：US13481575
申请日：2012-05-25
IPC分类号： C07K17/00
CPC分类号： A61L27/16 , A61B17/68 , A61B17/70 , A61B17/7062 , A61B17/72 , A61B2017/00526 , A61F2/0059 , A61F2/24 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/4241 , A61F2/44 , A61F2/4465 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61F2210/0004 , A61F2310/00365 , A61L26/0033 , A61L26/008 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , C08H1/06 , C08K3/013 , C08L5/04 , C08L5/08 , C08L67/04 , C08L89/06 , C08L2205/16
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
摘要翻译： 本发明包括用于施用于组织部位以促进或促进新组织生长的可延展的，可生物降解的纤维组合物。 本发明的一个方面是提供独特的机械和物理性质的纤维组分。 本发明可以通过提供含有浆料的容器来产生，所述浆料包含多个天然或合成聚合物纤维和至少一种悬浮液，其中所述聚合物纤维基本均匀地分散并随机取向于整个悬浮液体积; 向包含所述浆料的所述容器施加力（例如离心），于是所述力用于使所述聚合物纤维迁移穿过悬浮液并聚集在容器的最远处，形成聚合物材料，所述聚合物材料包含 聚合物纤维具有足够的长度并且足够粘稠，交错或互锁以阻止所述聚合物纤维的解离。
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10.发明授权公开(公告)号：US08389588B2
公开(公告)日：2013-03-05
申请号：US12577047
申请日：2009-10-09
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61B17/80 , A61B17/866 , A61L27/56
摘要： A high strength porous biphasic polymeric reinforcement material manufactured by a compression and/or sintering process is disclosed. The material results in a network of interconnected collapsed pores, which forces thin overlapping walls and passages to be created. The network provides permeable access for fluid migration throughout the material. The strength and/or permeability are advantageous for medical devices and implants.
摘要翻译： 公开了通过压缩和/或烧结工艺制造的高强度多孔双相聚合物增强材料。 该材料导致相互连接的塌陷孔的网络，这迫使薄的重叠壁和通道产生。 网络为整个材料的流体迁移提供可渗透性。 强度和/或渗透性对于医疗装置和植入物是有利的。
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