Process for the preparation of 2-ethoxy-4,6-dihydroxypyrimidine
    6.
    发明授权
    Process for the preparation of 2-ethoxy-4,6-dihydroxypyrimidine 失效
    2-乙氧基-4,6-二羟基嘧啶的制备方法

    公开(公告)号:US5552546A

    公开(公告)日:1996-09-03

    申请号:US282398

    申请日:1994-07-28

    IPC分类号: C07D239/60 C07D239/02

    CPC分类号: C07D239/60

    摘要: A salt of 2-ethoxy-4,6-dihydroxypyrimidine (DHEP) is prepared by contacting a salt of O-ethylisourea with dimethyl malonate in the presence of a methoxide base to form the salt of DHEP. The salt of DHEP can optionally be protonated with an acid to form neutral DHEP. The reaction is typically conducted in a methanol solvent at a temperature less than about 30.degree. C. Typically, the monosodium salt of DHEP is prepared by contacting O-ethylisourea hydrochloride with dimethyl malonate in the presence of sodium methoxide and methanol solvent.

    摘要翻译: 通过在甲醇盐碱存在下使O-乙基异脲的盐与丙二酸二甲酯接触以制备DHEP的盐来制备2-乙氧基-4,6-二羟基嘧啶(DHEP)的盐。 DHEP的盐可任选地用酸质子化形成中性DHEP。 反应通常在甲醇溶剂中在低于约30℃的温度下进行。通常,在甲醇钠和甲醇溶剂存在下,通过使O-乙基异脲盐酸盐与丙二酸二甲酯接触来制备DHEP的单钠盐。

    PROCESS FOR THE PREPARATION OF
2-TRIFLUOROMETHYL-5-(1-SUBSTITUTED)ALKYLPYRIDINES
    7.
    发明申请
    PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL-5-(1-SUBSTITUTED)ALKYLPYRIDINES 有权
    制备2-三氟甲基-5-(1-取代的)烷基吡啶的方法

    公开(公告)号:US20120142933A1

    公开(公告)日:2012-06-07

    申请号:US13303182

    申请日:2011-11-23

    IPC分类号: C07D213/32

    CPC分类号: C07D213/32

    摘要: 2-Trifluoromethyl-5-(1-substituted)alkylpyridines are produced efficiently and in high yield from an 4-alkoxy-1,1,1-trifluorobut-3-en-2-one by a condensation and a cyclization reaction. Both reactions are performed in the same nonpolar solvent without isolation and purification of intermediates.

    摘要翻译: 通过缩合和环化反应,由4-烷氧基-1,1,1-三氟丁-3-烯-2-酮有效地以高收率生产2-三氟甲基-5-(1-取代的)烷基吡啶。 两种反应都是在相同的非极性溶剂中进行,而不需要分离和纯化中间体。