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    MIDDLE-INFRARED VOLUMETRIC BRAGG GRATING BASED ON ALKALI HALIDE COLOR CENTER CRYSTALS
    5.
    发明申请
    MIDDLE-INFRARED VOLUMETRIC BRAGG GRATING BASED ON ALKALI HALIDE COLOR CENTER CRYSTALS 审中-公开
    基于ALKALI HALIDE彩色中心晶体的中红外体积分数

    公开(公告)号：US20140348200A1

    公开(公告)日：2014-11-27

    申请号：US14371970

    申请日：2013-01-14

    申请人： The UAB Research Foundation

    发明人： Anitha Arumugam ,  Dmitry V. Martyshkin ,  Vladimir V. Fedorov ,  David J. Hilton ,  Sergey B. Mirov

    IPC分类号： H01S3/08 ,  G02B5/18 ,  G03F7/20 ,  G02B6/124

    CPC分类号： H01S3/08009 ,  G02B1/02 ,  G02B5/1857 ,  G02B5/1861 ,  G02B6/124 ,  G03F7/20

    摘要： Volumetric Bragg grating devices that operate in middle-infrared region of the spectrum and methods for producing such devices are described. Such a Volumetric Bragg grating device can be produced by forming a plurality of color centers within an alkali-halide crystal and selectively removing a subset of the plurality of color centers to produce variations in refractive index of the alkali-halide crystal in the middle-infrared spectral region and to thereby produce a volumetric Bragg grating that operates in middle-infrared spectral range.

    摘要翻译： 描述了在频谱的中红外区域中操作的体积布拉格光栅装置以及用于制造这种装置的方法。 这样的体积布拉格光栅装置可以通过在碱卤化物晶体内形成多个颜色中心并选择性地去除多个颜色中心的子集来产生中间红外线中的碱卤化物晶体的折射率变化 并且由此产生在中红外光谱范围内操作的体积布拉格光栅。

    PHOTOTHERMAL NANOSTRUCTURES IN TUMOR THERAPY
    6.
    发明申请
    PHOTOTHERMAL NANOSTRUCTURES IN TUMOR THERAPY 审中-公开
    肿瘤治疗中的光热纳米结构

    公开(公告)号：US20130261444A1

    公开(公告)日：2013-10-03

    申请号：US13841259

    申请日：2013-03-15

    申请人： THE UAB RESEARCH FOUNDATION

    发明人： Hadiyah-Nicole Green ,  Sergey B. Mirov ,  Eben L. Rosenthal ,  Paul Castellanos ,  Dmitry V. Martyshkin

    IPC分类号： A61N5/06 ,  B05D3/10

    CPC分类号： A61N5/062 ,  A61N2005/063 ,  A61N2005/0644 ,  A61N2005/0659 ,  B05D3/108

    摘要： Methods, structures, devices and systems are disclosed for implementing a photothermal therapy using nanostructures. In one aspect, a device to produce a photothermal effect includes a particle having a molecular layer functionalized onto the external surface of the particle and structured to attach to one or more targeting molecules capable of binding to a receptor site of a cell, in which the particle is configured to absorb light energy at a particular wavelength to produce a plasmon resonance effect that causes the particle to emit heat energy. In some implementations, the device is deployed in an organism having a tumor that includes a plurality of the cell and binds to the receptor site of the tumor by the targeting molecules, in which the light energy is emitted at a region of the organism that contains the tumor and the heat energy causes cellular death of the tumor cell.

    摘要翻译： 公开了用于实施使用纳米结构的光热疗法的方法，结构，装置和系统。 在一个方面，产生光热效应的装置包括具有官能化到颗粒的外表面上并被构造成附着到一个或多个能够结合细胞的受体位点的靶向分子的分子层的颗粒，其中 颗粒被配置为吸收特定波长的光能以产生使得颗粒发射热能的等离子体共振效应。 在一些实施方案中，该装置部署在具有包括多个细胞并且通过靶向分子结合到肿瘤的受体位点的肿瘤的生物体中，其中光能量在包含 肿瘤和热能导致肿瘤细胞的细胞死亡。

    MIDDLE-INFRARED VOLUMETRIC BRAGG GRATING BASED ON ALKALI HALIDE OR ALKILI-EARTH FLOURIDE COLOR CENTER CRYSTALS
    10.
    发明申请
    MIDDLE-INFRARED VOLUMETRIC BRAGG GRATING BASED ON ALKALI HALIDE OR ALKILI-EARTH FLOURIDE COLOR CENTER CRYSTALS 审中-公开
    基于ALKALI卤化物或碱性金属粉末中等颜料中心晶体的中红外体积分数

    公开(公告)号：US20140321494A1

    公开(公告)日：2014-10-30

    申请号：US14330884

    申请日：2014-07-14

    申请人： The UAB Research Foundation

    发明人： Anitha Arumugam ,  Dmitry V. Martyshkin ,  Vladimir V. Fedorov ,  David J. Hilton ,  Sergey B. Mirov

    IPC分类号： H01S3/10 ,  G02B5/18

    CPC分类号： G02B5/1857 ,  G02B5/1861

    摘要： Volumetric Bragg grating devices that operate in middle-infrared region of the spectrum and methods for producing such devices are described. Such a Volumetric Bragg grating device can be produced by forming a plurality of color centers within an alkali-halide or an alkali-earth fluoride crystal and selectively removing a subset of the plurality of color centers to produce variations in refractive index of the alkali-halide or alkali-earth fluoride crystal in the middle-infrared spectral region and to thereby produce a volumetric Bragg grating that operates in middle-infrared spectral range.

    摘要翻译： 描述了在频谱的中红外区域中操作的体积布拉格光栅装置以及用于制造这种装置的方法。 这样的体积布拉格光栅装置可以通过在碱金属卤化物或碱土金属氟化物晶体内形成多个颜色中心并选择性地去除多个颜色中心的子集来产生碱卤化物的折射率变化 或中红外光谱区域中的碱土氟化物晶体，从而产生在中红外光谱范围内操作的体积布拉格光栅。