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公开(公告)号：US11180744B2
公开(公告)日：2021-11-23
申请号：US16454045
申请日：2019-06-26
发明人： Vincent Fischetti , Raymond Schuch , Rolf Lood , Benjamin Winer
IPC分类号： A61K47/64 , A61K38/16 , A61K38/47 , A61K38/00 , C12N9/24 , C12N9/88 , A61K9/00 , A61L2/16 , A61L29/04 , A61L29/08 , A61L29/16 , C12N9/96
摘要： Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acintobacter lysin polypeptides.
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公开(公告)号：US10590403B2
公开(公告)日：2020-03-17
申请号：US15321905
申请日：2015-06-26
发明人： Vincent Fischetti , Raymond Schuch , Rolf Lood , Benjamin Winer
IPC分类号： A61K9/00 , A61K38/00 , A61K47/64 , A61K38/16 , A61K38/47 , C12N9/96 , C12N9/88 , C12N9/24 , A61L2/16 , A61L29/04 , A61L29/08 , A61L29/16
摘要： Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acinetobacter lysin polypeptides.
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公开(公告)号：US20160018397A1
公开(公告)日：2016-01-21
申请号：US14332060
申请日：2014-07-15
发明人： Vincent Fischetti , Raymond Schuch , Sherry Kan
IPC分类号： G01N33/569 , C12N7/00 , G01N21/64 , C07K14/005
CPC分类号： G01N33/56911 , C07K14/005 , C07K2319/21 , C12N7/00 , C12N2795/10021 , C12N2795/10022 , C12N2795/10031 , C12Q1/04 , G01N21/6486 , G01N2333/32 , G01N2333/705
摘要： The present disclosure provides recombinant phages, a Wip1 p23 receptor binding protein and a Wip1 p24 receptor binding protein that bind to Bacillus anthracis. The disclosure further provides methods and uses thereof.
摘要翻译： 本公开提供重组噬菌体，Wip1 p23受体结合蛋白和结合炭疽芽孢杆菌的Wip1 p24受体结合蛋白。 本公开进一步提供其方法和用途。
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公开(公告)号：US11622999B2
公开(公告)日：2023-04-11
申请号：US16772048
申请日：2018-12-11
发明人： Vincent Fischetti , Qiong Wang
摘要： Provided are compositions and methods for use in selectively killing one or more of C. perfringens, C. sordelli and C. histolyticum. The compositions include lysin PlyCP025, as well as catalytically active fragments thereof, and variants thereof that retain killing activity. Methods for reducing one or more of C. perfringens, C. sordelli or C. histolyticum bacteria are provide and involve contacting such bacteria with a composition that contains PlyCP025 or an enzymatically active fragment or variant thereof, which can be provided as recombinant polypeptides. The composition and methods are useful for human and veterinary purposes. Diagnostic approaches are also included by contacting a sample obtained or derived from an animal, with a recombinant polypeptide, and detecting binding of the polypeptide to bacteria in the sample if said bacteria that are bound to the polypeptide are present in the sample. The polypeptide may thus be detectably labeled to produce a detectable signal.
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公开(公告)号：US09404922B2
公开(公告)日：2016-08-02
申请号：US14332060
申请日：2014-07-15
发明人： Vincent Fischetti , Raymond Schuch , Sherry Kan
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/554 , G01N33/567 , G01N33/569 , C07K14/005 , C12N7/00 , G01N21/64
CPC分类号： G01N33/56911 , C07K14/005 , C07K2319/21 , C12N7/00 , C12N2795/10021 , C12N2795/10022 , C12N2795/10031 , C12Q1/04 , G01N21/6486 , G01N2333/32 , G01N2333/705
摘要： The present disclosure provides recombinant phages, a Wip1 p23 receptor binding protein and a Wip1 p24 receptor binding protein that bind to Bacillus anthracis. The disclosure further provides methods and uses thereof.
摘要翻译： 本公开提供重组噬菌体，Wip1 p23受体结合蛋白和结合炭疽芽孢杆菌的Wip1 p24受体结合蛋白。 本公开进一步提供其方法和用途。
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公开(公告)号：US20170130214A1
公开(公告)日：2017-05-11
申请号：US15321905
申请日：2015-06-26
发明人： Vincent Fischetti , Raymond Schuch , Rolf Lood , Benjamin Winer
IPC分类号： C12N9/24 , A61K38/47 , A61L29/04 , A61L2/16 , A61L29/08 , A61K9/00 , A61K38/16 , C12N9/96 , A61L29/16
摘要： Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acinetobacter lysin polypeptides.
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