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公开(公告)号：US20240115679A1
公开(公告)日：2024-04-11
申请号：US18529758
申请日：2023-12-05
发明人： James J. Moon , Rui Kuai , Anna A. Schwendeman , Jutaek Nam
IPC分类号： A61K39/00 , A61K9/127 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K45/06 , A61K47/54 , A61K47/69 , C12N15/11 , C12N15/113
CPC分类号： A61K39/0011 , A61K9/127 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K39/001106 , A61K39/00111 , A61K39/001132 , A61K39/001151 , A61K39/001156 , A61K39/001157 , A61K39/001162 , A61K39/001164 , A61K39/001166 , A61K39/001176 , A61K39/001181 , A61K39/001182 , A61K39/001184 , A61K39/001186 , A61K39/001188 , A61K39/001189 , A61K39/001191 , A61K39/001192 , A61K39/001193 , A61K39/001194 , A61K39/001195 , A61K39/001197 , A61K45/06 , A61K47/554 , A61K47/6917 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
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2.发明公开公开(公告)号：US20240277751A1
公开(公告)日：2024-08-22
申请号：US18031832
申请日：2021-10-15
发明人： James J. Moon , Xiaoqi Sun , Kyung Soo Park , Xuehui Huang
IPC分类号： A61K31/7084 , A61K39/12 , A61K45/06 , A61K47/60 , A61K47/64
CPC分类号： A61K31/7084 , A61K39/12 , A61K45/06 , A61K47/60 , A61K47/6455 , A61K2039/572 , C07B2200/13
摘要： This disclosure provides compositions and methods for stimulating the innate immune response in a subject with agents capable of stimulating an innate immune response in a subject upon administration to the subject. In particular, the present invention is directed to crystalline polymorphic forms (e.g. coordinate polymeric forms) of STING agonists associated (e.g. mixed) with one or more metal ions (e.g., Zn2+, Mn2+, Al3+, Fe3+, Cu2+), as well as systems and methods utilizing such compositions (e.g., in therapeutic settings).
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公开(公告)号：US20230346826A1
公开(公告)日：2023-11-02
申请号：US18027763
申请日：2021-09-23
发明人： James J. Moon , Kai Han , Fang Xie , Xingwu ZHOU
IPC分类号： A61P37/06 , A61K47/36 , A61K31/733 , A61K9/00
CPC分类号： A61K31/733 , A61K9/0053 , A61K47/36 , A61P37/06
摘要： This invention relates generally to compositions comprising a gel-based inulin formulation associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) one or more therapeutic agents (e.g., immunomodulatory agent, immunosuppressant, allergen) and related methods for the treatment of autoimmune disorders (e.g., colitis) (e.g, allergy, such as food allergy). Also provided herein are compositions and methods for modulating an immune response associated with an autoimmune disorder (e.g., allergy) and/or inducing immune tolerance or desensitization to an autoimmune disorder (e.g., allergy, such as a food allergy).
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公开(公告)号：US20180078625A1
公开(公告)日：2018-03-22
申请号：US15561374
申请日：2016-03-25
发明人： James J. Moon , Rui Kuai , Anna A. Schwendeman , Jutaek Nam
IPC分类号： A61K39/00 , A61K45/06 , C12N15/113 , A61K31/7088 , A61K47/69
CPC分类号： A61K39/0011 , A61K9/127 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K45/06 , A61K47/554 , A61K47/6917 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
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公开(公告)号：US20240173418A1
公开(公告)日：2024-05-30
申请号：US18284035
申请日：2022-03-23
发明人： James J. Moon , Xiaoqi Sun
CPC分类号： A61K47/549 , A61K45/06 , A61K49/0032 , A61K49/0052 , A61K49/085 , A61K49/10 , A61K51/0491
摘要： This invention is in the field of medicinal chemistry and relates to a new class of cyclic dinucleotide conjugates (e.g., Formula I) which function as tumor-targeted imaging agents, and their use in diagnostic and therapeutic intervention for disorders (e.g., cancer).
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6.发明申请公开(公告)号：US20220072023A1
公开(公告)日：2022-03-10
申请号：US17259819
申请日：2019-07-12
发明人： James J. Moon , Xiaoqi Sun
IPC分类号： A61K31/7084 , A61K31/4745 , A61K31/7068 , A61K31/52 , A61K39/39 , A61K39/00 , A61K39/395 , A61K31/573 , A61K31/42 , A61K31/519 , A61K31/192 , A61K31/167 , A61K38/20 , A61K33/242 , A61K31/655 , A61K31/5415 , A61K31/196 , A61K31/353 , A61K31/7034 , A61K31/7048 , A61K31/366 , A61K31/409 , A61K31/198 , A61K31/395 , A61K9/16 , A61K9/127 , A61K47/69 , A61P37/06
摘要： This disclosure provides compositions and methods for stimulating the innate immune response in a subject with agents capable of stimulating an innate immune response in a subject upon administration to the subject (e.g., damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs)). In particular, the present invention is directed to compositions of DAMPs/PAMPs and metals ions, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
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公开(公告)号：US11219673B2
公开(公告)日：2022-01-11
申请号：US15561374
申请日：2016-03-25
发明人： James J. Moon , Rui Kuai , Anna A. Schwendeman , Jutaek Nam
IPC分类号： A61K47/69 , A61K39/00 , A61K9/127 , A61K31/713 , A61K47/54 , A61K31/712 , C12N15/11 , A61K31/7088 , A61K45/06 , C12N15/113
摘要： The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
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公开(公告)号：US12050215B2
公开(公告)日：2024-07-30
申请号：US15776346
申请日：2016-11-16
IPC分类号： G01N33/544 , A01N25/10 , A01N57/16 , C12N11/089
CPC分类号： G01N33/544 , A01N25/10 , A01N57/16 , C12N11/089 , G01N2500/04
摘要： Provided herein are macromolecular structures comprising charged macromolecules. In particular, provided herein are synthetic neutrophil extracellular traps and uses thereof.
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公开(公告)号：US20230001010A1
公开(公告)日：2023-01-05
申请号：US17628418
申请日：2020-07-17
摘要： The present invention relates to compositions comprising nanoparticles associated with a plurality of tolerogenic antigens (e.g., between 1-30 tolerogenic 5 antigens per nanoparticle) in such a manner that facilitates strong immune tolerance upon administration to a subject (e.g., a human subject suffering from or at risk of suffering from an autoimmune disorder e.g., MS or celiac disease). The present invention further relates to methods for utilizing such nanoparticles to treat autoimmune disorders (e.g., MS or celiac disease).
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公开(公告)号：US20210106538A1
公开(公告)日：2021-04-15
申请号：US16310715
申请日：2017-06-20
发明人： James J. Moon , Rui Kuai , Anna A. Schwendeman , Jutaek Nam
IPC分类号： A61K9/51 , A61K39/39 , A61K47/69 , C12N15/113 , A61P35/00 , A61P37/04 , A61K39/00 , A61K9/127 , A61K33/38 , A61K38/17 , A61K39/395
摘要： The present invention relates to nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
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