公开(公告)号：US11890356B2

公开(公告)日：2024-02-06

申请号：US17455170

申请日：2021-11-16

Applicant: The General Hospital Corporation

Inventor： Jacob Hooker ,  Changning Wang ,  Martin Georg Strebl-Bantillo ,  Johanna Kaarina Rokka

IPC: A61K51/04 ,  C07C259/10

CPC classification number: A61K51/04 ,  C07C259/10 ,  C07B2200/05 ,  C07C2602/42 ,  C07C2603/74

Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.

公开(公告)号：US20240148915A1

公开(公告)日：2024-05-09

申请号：US18390906

申请日：2023-12-20

Applicant: The General Hospital Corporation

Inventor： Jacob Hooker ,  Changning Wang ,  Martin Georg Strebl-Bantillo ,  Johanna Kaarina Rokka

IPC: A61K51/04 ,  C07C259/10

CPC classification number: A61K51/04 ,  C07C259/10 ,  C07B2200/05 ,  C07C2602/42 ,  C07C2603/74

Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.

公开(公告)号：US20210030899A1

公开(公告)日：2021-02-04

申请号：US17066925

申请日：2020-10-09

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC: A61K51/04 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07D235/08 ,  C07D267/16 ,  C07D209/08 ,  C07D209/14 ,  C07D281/12

Abstract: Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.

公开(公告)号：US10188756B2

公开(公告)日：2019-01-29

申请号：US15030214

申请日：2014-10-17

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC: A61K51/04 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07D235/08 ,  C07D267/16 ,  C07D209/08 ,  C07D209/14 ,  C07D281/12

Abstract: Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.

公开(公告)号：US20240174608A1

公开(公告)日：2024-05-30

申请号：US18279162

申请日：2022-03-11

Applicant: The General Hospital Corporation

Inventor： Changning Wang ,  Yulong Xu ,  Can Zhang ,  Rudolph E. Tanzi

IPC: C07D209/88 ,  A61K51/04 ,  C07B59/00

CPC classification number: C07D209/88 ,  A61K51/0446 ,  C07B59/002 ,  A61K2123/00 ,  C07B2200/05

Abstract: The present application provides radiolabeled tetrahydrocarbazole compounds that can be used as positron emission tomography imaging probes. Pharmaceutical compositions and methods of using these compounds for diagnosis and monitoring treatment of neurodegenerative diseases (such as Alzheimer's disease) are also provided.

公开(公告)号：US20220133916A1

公开(公告)日：2022-05-05

申请号：US17455170

申请日：2021-11-16

Applicant: The General Hospital Corporation

Inventor： Jacob Hooker ,  Changning Wang ,  Martin Georg Strebl-Bantillo ,  Johanna Kaarina Rokka

IPC: A61K51/04 ,  C07C259/10

Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.

公开(公告)号：US20200054773A1

公开(公告)日：2020-02-20

申请号：US16603746

申请日：2018-04-11

Applicant: The General Hospital Corporation

Inventor： Jacob Hooker ,  Changning Wang ,  Martin Georg Strebl-Bantillo ,  Johanna Kaarina Rokka

IPC: A61K51/04 ,  C07C259/10

Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.

公开(公告)号：US20170349540A1

公开(公告)日：2017-12-07

申请号：US15329346

申请日：2015-07-27

Applicant: The General Hospital Corporation

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick A. Schroeder

IPC: C07C259/06 ,  C07C237/20 ,  C07C2603/74

CPC classification number: C07C259/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C233/80 ,  C07C237/20 ,  C07C259/10 ,  C07C2601/14 ,  C07C2603/74 ,  C07D205/04 ,  C07D213/40 ,  C07D333/20 ,  C07D401/12 ,  C07D409/12

Abstract: Provided herein are brain penetrant histone deacetylase (HDAC) inhibitors useful for treating diseases or disorders associated with HDAC. An exemplary HDAC inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1. Pharmaceutical compositions comprising HDAC inhibitors and methods for treating diseases associated with HDAC are also provided.

公开(公告)号：US11207431B2

公开(公告)日：2021-12-28

申请号：US16603746

申请日：2018-04-11

Applicant: The General Hospital Corporation

Inventor： Jacob Hooker ,  Changning Wang ,  Martin Georg Strebl-Bantillo

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  C07C259/10

Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.

公开(公告)号：US20190240357A1

公开(公告)日：2019-08-08

申请号：US16213358

申请日：2018-12-07

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC: A61K51/04 ,  C07D267/16 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07D281/12 ,  C07D209/14 ,  C07D209/08 ,  C07C259/06 ,  C07D235/08 ,  C07C311/21

CPC classification number: A61K51/04 ,  C07B2200/05 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/74 ,  C07D209/08 ,  C07D209/14 ,  C07D235/08 ,  C07D267/16 ,  C07D281/12

Abstract: Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.