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公开(公告)号：US20240148915A1
公开(公告)日：2024-05-09
申请号：US18390906
申请日：2023-12-20
Applicant: The General Hospital Corporation
Inventor： Jacob Hooker , Changning Wang , Martin Georg Strebl-Bantillo , Johanna Kaarina Rokka
IPC: A61K51/04 , C07C259/10
CPC classification number: A61K51/04 , C07C259/10 , C07B2200/05 , C07C2602/42 , C07C2603/74
Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
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公开(公告)号：US11890356B2
公开(公告)日：2024-02-06
申请号：US17455170
申请日：2021-11-16
Applicant: The General Hospital Corporation
Inventor： Jacob Hooker , Changning Wang , Martin Georg Strebl-Bantillo , Johanna Kaarina Rokka
IPC: A61K51/04 , C07C259/10
CPC classification number: A61K51/04 , C07C259/10 , C07B2200/05 , C07C2602/42 , C07C2603/74
Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
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公开(公告)号：US20220133916A1
公开(公告)日：2022-05-05
申请号：US17455170
申请日：2021-11-16
Applicant: The General Hospital Corporation
Inventor： Jacob Hooker , Changning Wang , Martin Georg Strebl-Bantillo , Johanna Kaarina Rokka
IPC: A61K51/04 , C07C259/10
Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
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公开(公告)号：US20200054773A1
公开(公告)日：2020-02-20
申请号：US16603746
申请日：2018-04-11
Applicant: The General Hospital Corporation
Inventor： Jacob Hooker , Changning Wang , Martin Georg Strebl-Bantillo , Johanna Kaarina Rokka
IPC: A61K51/04 , C07C259/10
Abstract: Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
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