公开(公告)号：US20190240357A1

公开(公告)日：2019-08-08

申请号：US16213358

申请日：2018-12-07

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC: A61K51/04 ,  C07D267/16 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07D281/12 ,  C07D209/14 ,  C07D209/08 ,  C07C259/06 ,  C07D235/08 ,  C07C311/21

CPC classification number: A61K51/04 ,  C07B2200/05 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/74 ,  C07D209/08 ,  C07D209/14 ,  C07D235/08 ,  C07D267/16 ,  C07D281/12

Abstract: Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.

公开(公告)号：US20180258090A1

公开(公告)日：2018-09-13

申请号：US15326890

申请日：2015-07-17

Applicant: The General Hospital Corporation

Inventor： Genevieve Van de Bittner ,  Jacob M. Hooker

IPC: C07D473/40 ,  C07B59/00 ,  A61K51/04 ,  C07D473/16 ,  C07D487/04

CPC classification number: C07D473/40 ,  A61K51/0459 ,  C07B59/002 ,  C07B2200/05 ,  C07D473/16 ,  C07D473/34 ,  C07D487/04

Abstract: Provided herein are radiolabeled compounds useful for non-invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography. The present application also provides unlabeled compounds useful in methods of treating diseases of the central nervous system or disease of the peripheral nervous system. Methods for preparing radiolabeled compounds, preparing unlabeled compounds, and diagnostic methods using labeled or unlabeled compounds are also provided.

公开(公告)号：US10519160B2

公开(公告)日：2019-12-31

申请号：US15326890

申请日：2015-07-17

Applicant: The General Hospital Corporation

Inventor： Genevieve Van de Bittner ,  Jacob M. Hooker

IPC: C07D473/40 ,  C07D473/16 ,  C07D487/04 ,  C07D473/34 ,  C07B59/00 ,  A61K51/04

Abstract: Provided herein are radiolabeled compounds useful for non-invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography. The present application also provides unlabeled compounds useful in methods of treating diseases of the central nervous system or disease of the peripheral nervous system. Methods for preparing radiolabeled compounds, preparing unlabeled compounds, and diagnostic methods using labeled or unlabeled compounds are also provided.

公开(公告)号：US20170349540A1

公开(公告)日：2017-12-07

申请号：US15329346

申请日：2015-07-27

Applicant: The General Hospital Corporation

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick A. Schroeder

IPC: C07C259/06 ,  C07C237/20 ,  C07C2603/74

CPC classification number: C07C259/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C233/80 ,  C07C237/20 ,  C07C259/10 ,  C07C2601/14 ,  C07C2603/74 ,  C07D205/04 ,  C07D213/40 ,  C07D333/20 ,  C07D401/12 ,  C07D409/12

Abstract: Provided herein are brain penetrant histone deacetylase (HDAC) inhibitors useful for treating diseases or disorders associated with HDAC. An exemplary HDAC inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1. Pharmaceutical compositions comprising HDAC inhibitors and methods for treating diseases associated with HDAC are also provided.

公开(公告)号：US20160228056A1

公开(公告)日：2016-08-11

申请号：US15022373

申请日：2014-09-17

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Marjorie Villien

IPC: A61B5/00 ,  G01R33/48 ,  A61B5/055 ,  A61B6/03 ,  A61B6/00

CPC classification number: A61B5/4866 ,  A61B5/0035 ,  A61B5/0042 ,  A61B5/0263 ,  A61B5/055 ,  A61B6/037 ,  A61B6/486 ,  A61B6/501 ,  A61B6/507 ,  A61B6/508 ,  A61B2576/026 ,  G01R33/481

Abstract: An emission tomography system and method are used to acquire a series of medical images of a subject during an imaging process using a radiotracer. The system includes detectors for acquiring gamma rays emitted from the subject after administration of the radiotracer. A stimulus system tracks a stimulus associated with the subject during imaging. A data processing system receives signals from the detectors and stimulus feedback from the stimulus system and correlates the signals with information about the stimulus associated with the subject. A reconstruction system receives the correlated signals and information about the stimulus from the data processing system and reconstructs a series of medical images of the subject showing a physiological response of the subject to the stimulus over a time period.

Abstract translation: 使用发射断层摄影系统和方法在使用放射性示踪器的成像过程中获取被摄体的一系列医学图像。 该系统包括用于在施用放射性示踪器之后获取从受试者发射的γ射线的检测器。 刺激系统在成像期间跟踪与受试者相关的刺激。 数据处理系统接收来自检测器的信号和来自刺激系统的刺激反馈，并将信号与关于与受试者相关联的刺激的信息相关联。 重建系统从数据处理系统接收相关信号和关于刺激的信息，并且重建在一段时间内显示受试者对刺激的生理反应的对象的一系列医学图像。

公开(公告)号：US20210030899A1

公开(公告)日：2021-02-04

申请号：US17066925

申请日：2020-10-09

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC: A61K51/04 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07D235/08 ,  C07D267/16 ,  C07D209/08 ,  C07D209/14 ,  C07D281/12

Abstract: Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.

公开(公告)号：US10188756B2

公开(公告)日：2019-01-29

申请号：US15030214

申请日：2014-10-17

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC: A61K51/04 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07D235/08 ,  C07D267/16 ,  C07D209/08 ,  C07D209/14 ,  C07D281/12

Abstract: Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.