公开(公告)号：US20170349540A1

公开(公告)日：2017-12-07

申请号：US15329346

申请日：2015-07-27

Applicant: The General Hospital Corporation

Inventor： Jacob M. Hooker ,  Changning Wang ,  Frederick A. Schroeder

IPC: C07C259/06 ,  C07C237/20 ,  C07C2603/74

CPC classification number: C07C259/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C233/80 ,  C07C237/20 ,  C07C259/10 ,  C07C2601/14 ,  C07C2603/74 ,  C07D205/04 ,  C07D213/40 ,  C07D333/20 ,  C07D401/12 ,  C07D409/12

Abstract: Provided herein are brain penetrant histone deacetylase (HDAC) inhibitors useful for treating diseases or disorders associated with HDAC. An exemplary HDAC inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1. Pharmaceutical compositions comprising HDAC inhibitors and methods for treating diseases associated with HDAC are also provided.