公开(公告)号：US20160264536A1

公开(公告)日：2016-09-15

申请号：US15031505

申请日：2014-10-22

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masaki SETO ,  Yoshihiro BANNO ,  Toshihiro IMAEDA ,  Yuichi KAJITA ,  Tomoko ASHIZAWA ,  Masanori KAWASAKI ,  Shinji NAKAMURA ,  Satoshi MIKAMI ,  Izumi NOMURA ,  Takahiko TANIGUCHI ,  Shogo MARUI

IPC: C07D277/56 ,  C07D403/12 ,  C07D239/28 ,  C07D403/04 ,  C07D239/47 ,  C07D239/36 ,  C07D239/52 ,  C07D241/24 ,  C07D498/08 ,  C07D413/04 ,  C07D405/04 ,  C07D401/04 ,  C07D417/04 ,  C07D409/04 ,  C07D401/12 ,  C07D239/42

CPC classification number: C07D277/56 ,  C07D239/28 ,  C07D239/36 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/52 ,  C07D239/54 ,  C07D239/56 ,  C07D241/24 ,  C07D241/26 ,  C07D277/20 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D498/04 ,  C07D498/08

Abstract: The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Abstract translation: 其中每个符号如说明书中所述或其盐。

公开(公告)号：US20170129887A1

公开(公告)日：2017-05-11

申请号：US15264213

申请日：2016-09-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi MIKAMI ,  Shinji NAKAMURA ,  Tomoko ASHIZAWA ,  Shigekazu SASAKI ,  Takahiko TANIGUCHI ,  Izumi NOMURA ,  Masanori KAWASAKI

IPC: C07D471/04 ,  A61K31/555 ,  A61K31/498 ,  A61K9/20 ,  C07F7/18

CPC classification number: C07D471/04 ,  A61K9/20 ,  A61K31/498 ,  A61K31/555 ,  C07D519/00 ,  C07F7/1804

Abstract: The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like.The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20160052897A1

公开(公告)日：2016-02-25

申请号：US14781665

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Izumi NOMURA ,  Yoshiteru ITO ,  Eiji KIMURA ,  Haruhi ANDO ,  Tomoaki HASUI ,  Toshiya NISHI

IPC: C07D263/32 ,  C07D491/08 ,  C07D413/04 ,  C07D413/14 ,  C07D413/12 ,  C07D413/10

CPC classification number: C07D263/32 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/08

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

Abstract translation: 本发明涉及式（I）表示的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 在式（I）中，每个符号如说明书中所定义。