公开(公告)号：US20160326136A1

公开(公告)日：2016-11-10

申请号：US15221761

申请日：2016-07-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Toshiya NISHI

IPC: C07D401/10 ,  C07D405/14 ,  C07D498/08 ,  C07D413/10 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US20210206781A1

公开(公告)日：2021-07-08

申请号：US16933092

申请日：2020-07-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY

IPC: C07D498/08 ,  C07D405/14 ,  C07D413/14 ,  C07D413/10 ,  C07D401/14 ,  C07D401/10 ,  C07D417/14 ,  C07D405/10

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.
The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20160024049A1

公开(公告)日：2016-01-28

申请号：US14781963

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Shuhei IKEDA ,  Yuichi KAJITA ,  Toshiya NISHI

IPC: C07D401/10 ,  C07D213/56 ,  C07D401/14 ,  C07D403/12 ,  C07D239/26 ,  C07D213/42 ,  C07D405/14 ,  C07D417/14 ,  C07D401/12 ,  C07D413/14

CPC classification number: C07D401/10 ,  C07D213/34 ,  C07D213/42 ,  C07D213/56 ,  C07D239/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20210139491A1

公开(公告)日：2021-05-13

申请号：US16622632

申请日：2018-06-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kazuaki TAKAMI ,  Masaki SETO ,  Shinobu SASAKI ,  Haruhi ANDO ,  Masaki OGINO ,  Tomoko OHASHI ,  Toshihiro IMAEDA ,  Ikuo FUJIMORI ,  Yasuhiro TSUKIMI ,  Masami YAMADA ,  Kenichiro SHIMOKAWA ,  Takeshi WAKABAYASHI ,  Masataka MURAKAMI ,  Makoto FUSHIMI ,  Tomohiro OKAWA ,  Jinichi YONEMORI ,  Tomohiro OHASHI ,  Hideo SUZUKI ,  Hironobu MAEZAKI ,  Ayumu SATO ,  Yasutomi ASANO ,  Steve SWANN

IPC: C07D491/048 ,  A61K31/4355 ,  A61P1/10

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20190233436A1

公开(公告)日：2019-08-01

申请号：US16381163

申请日：2019-04-11

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY

IPC: C07D498/08 ,  C07D405/10 ,  C07D417/14 ,  C07D413/10 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/10

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20190071455A1

公开(公告)日：2019-03-07

申请号：US16194540

申请日：2018-11-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY ,  Toshiya NISHI

IPC: C07D498/08 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D401/10 ,  C07D413/10 ,  C07D417/14 ,  C07D401/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20230303541A1

公开(公告)日：2023-09-28

申请号：US18081395

申请日：2022-12-14

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinobu SASAKI ,  Masaki SETO ,  Kazuaki TAKAMI ,  Haruhi ANDO

IPC: C07D405/14 ,  C07D405/04 ,  C07D409/14 ,  A61P1/10

CPC classification number: C07D405/14 ,  A61P1/10 ,  C07D405/04 ,  C07D409/14

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I):





wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20210380565A1

公开(公告)日：2021-12-09

申请号：US17280633

申请日：2019-09-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinobu SASAKI ,  Yasutomi ASANO ,  Kazuaki TAKAMI ,  Masaki SETO ,  Haruhi ANDO

IPC: C07D405/14 ,  A61P1/10 ,  C07D407/12 ,  C07D413/14 ,  C07D417/14 ,  C07D407/14

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group; and ring A is an optionally further substituted ring, or a salt thereof.

公开(公告)号：US20210292308A1

公开(公告)日：2021-09-23

申请号：US16606043

申请日：2018-04-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shinobu SASAKI ,  Masaki SETO ,  Kazuaki TAKAMI ,  Haruhi ANDO

IPC: C07D405/14 ,  C07D405/04 ,  C07D409/14 ,  A61P1/10

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, salt thereof.

公开(公告)号：US20200157117A1

公开(公告)日：2020-05-21

申请号：US16779797

申请日：2020-02-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Masato YOSHIKAWA ,  Haruhi ANDO ,  William John FARNABY

IPC: C07D498/08 ,  C07D405/14 ,  C07D413/14 ,  C07D413/10 ,  C07D401/14 ,  C07D401/10 ,  C07D417/14 ,  C07D405/10

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.