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公开(公告)号：US20240309016A1
公开(公告)日：2024-09-19
申请号：US18606857
申请日：2024-03-15
发明人： Mitsunori KONO , Yusuke SASAKI , Yuya OGURO , Zenichi IKEDA , Osamu KUBO , Masaki SETO , Toru YAMASHITA , Makoto KAMATA , Kenjiro SATO , Matthew Thomas REYNOLDS , Kazuaki TAKAMI , Asato KINA , Takafumi YUKAWA , Minoru NAKAMURA , Taku KAMEI , Hiroyuki KAKEI , Fumie YAMAGUCHI , Tomohiro OHASHI , Keiko KAKEGAWA , Takuto KOJIMA , Florian PÜNNER , Masataka MURAKAMI , Takahiko TANIGUCHI , Tatsuki KOIKE , Yuichi KAJITA , Yuhei MIYANOHANA , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Yasushi HATTORI , Eiji KIMURA , Martin Alexander PAWLICZEK , Marilena PIRA , Shuhei IKEDA , Noriyuki TEZUKA , Yoshikazu WATANABE , Kevin CURRAN , Nicolle DOERING , Maria HOPKINS , Ben JOHNSON , Andre KIRYANOV , Jon LAM , Sean MURPHY , Natasha O'ROURKE , Holly REICHARD , Paul TANIS , Yunlong ZHANG
IPC分类号： C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
CPC分类号： C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20230063805A1
公开(公告)日：2023-03-02
申请号：US17846830
申请日：2022-06-22
发明人： Yuichi KAJITA , Yuhei MIYANOHANA , Tatsuki KOIKE , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D211/36 , C07D405/06 , A61P25/26 , C07D409/10 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20230042358A1
公开(公告)日：2023-02-09
申请号：US17413469
申请日：2019-12-11
发明人： Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Yasushi HATTORI , Norihito TOKUNAGA , Tsuneo ODA , Tohru MIYAZAKI , Dilhumar UYGHUR , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO , Koichiro FUKUDA , Yasuhisa KOHARA , Rei OKAMOTO , Taiichi OHRA , Naoki MIYAMOTO , Jun CHIBA , Yoshito TERAO , Masanori KAWASAKI
IPC分类号： C07D455/02 , A61P25/26 , C07D471/04 , C07D217/24 , C07D239/90 , C07D237/32 , C07D401/10 , C07D403/10 , C07D498/04 , C07D417/06 , C07D401/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20190040010A1
公开(公告)日：2019-02-07
申请号：US16052967
申请日：2018-08-02
发明人： Yuichi Kajita , Satoshi MIKAMI , Yuhei MIYANOHANA , Tatsuki KOIKE , Masaki DAINI , Norio OHYABU , Masaki OGINO , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D401/10 , C07D401/06 , C07D207/14 , C07D405/10 , C07D417/06 , C07D405/12 , C07D413/06 , C07D401/14 , C07D205/04 , C07D403/06 , C07D417/14 , A61P25/00
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20160052897A1
公开(公告)日：2016-02-25
申请号：US14781665
申请日：2014-04-03
发明人： Tatsuki KOIKE , Masato YOSHIKAWA , Izumi NOMURA , Yoshiteru ITO , Eiji KIMURA , Haruhi ANDO , Tomoaki HASUI , Toshiya NISHI
IPC分类号： C07D263/32 , C07D491/08 , C07D413/04 , C07D413/14 , C07D413/12 , C07D413/10
CPC分类号： C07D263/32 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D491/08
摘要： The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
摘要翻译： 本发明涉及式（I）表示的化合物，其可用作预防或治疗癫痫，神经变性疾病等的药剂。 在式（I）中，每个符号如说明书中所定义。
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公开(公告)号：US20230040770A1
公开(公告)日：2023-02-09
申请号：US17427490
申请日：2020-01-30
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Tatsuki KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D403/06 , C07D207/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20210276949A1
公开(公告)日：2021-09-09
申请号：US17239191
申请日：2021-04-23
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D207/14 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20200207715A1
公开(公告)日：2020-07-02
申请号：US16811426
申请日：2020-03-06
发明人： Yuichi Kajita , Yuhei MIYANOHANA , Tatsuki KOIKE , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D417/14 , C07D417/06 , C07D413/06 , C07D405/12 , C07D405/10 , C07D403/06 , C07D401/14 , C07D401/10 , C07D401/06 , C07D207/14 , C07D205/04 , A61P25/00 , C07D405/06 , C07D211/36
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20200017444A1
公开(公告)日：2020-01-16
申请号：US16577449
申请日：2019-09-20
发明人： Yuichi KAJITA , Satoshi MIKAMI , Yuhei MIYANOHANA , Tatsuki KOIKE , Masaki DAINI , Norio OYABU , Masaki OGINO , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14 , C07D211/36 , C07D405/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20230322683A1
公开(公告)日：2023-10-12
申请号：US17766400
申请日：2020-10-15
IPC分类号： C07D231/56 , C07D405/12 , C07D471/04 , C07D498/04 , A61P25/28
CPC分类号： C07D231/56 , C07D405/12 , C07D471/04 , C07D498/04 , A61P25/28
摘要： The present invention provides a compound having a cell degeneration inhibitory action, particularly a motor neuron degeneration inhibitory action, which is useful as an agent for the prophylaxis or treatment of motor neuron diseases (e.g., amyotrophic lateral sclerosis, progressive bulbar paralysis, progressive muscular atrophy, primary lateral sclerosis, progressive pseudobulbar paralysis, spinal muscular atrophy, Parkinson's disease, Lewy body dementia, multiple-system atrophy, Friedreich's ataxia) and the like.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof.
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