公开(公告)号：US10807061B2

公开(公告)日：2020-10-20

申请号：US15412908

申请日：2017-01-23

申请人： TOPPAN PRINTING CO., LTD.

发明人： Takumi Hirase ,  Rii Morimura ,  Masato Nakayama

IPC分类号： B01J13/20 ,  G01N33/92 ,  B01J13/00 ,  C09K11/06 ,  G01N21/64 ,  G01N33/58 ,  G01N21/78

摘要： In methods of separating, moving, and detecting a vesicle of the present invention, either a vesicular-shaped lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane, or a lipid-membrane-structure-immobilization carrier, in which a lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane is immobilized on a carrier, is brought into contact with a sample containing the vesicle such that membrane fusion occurs between the lipid membrane structure and the vesicle.

公开(公告)号：US09632077B2

公开(公告)日：2017-04-25

申请号：US14589492

申请日：2015-01-05

申请人： TOPPAN PRINTING CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Takumi Hirase ,  Masato Nakayama ,  Hiroshi Handa ,  Satoshi Sakamoto ,  Yasuyuki Naito

IPC分类号： G01N33/543 ,  G01N21/64

CPC分类号： G01N33/54326 ,  G01N21/6428 ,  G01N21/645

摘要： A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.

公开(公告)号：US11898194B2

公开(公告)日：2024-02-13

申请号：US16872855

申请日：2020-05-12

申请人： TOPPAN PRINTING CO., LTD.

发明人： Takumi Hirase ,  Yoichi Makino ,  Yosuke Horiuchi

IPC分类号： C12Q1/68 ,  C12Q1/6806 ,  B01L3/00 ,  C12Q1/686 ,  G01N33/536

CPC分类号： C12Q1/6806 ,  B01L3/5027 ,  C12Q1/686 ,  G01N33/536 ,  B01L2200/0689 ,  B01L2300/0829

摘要： A method for detecting a target molecule, including supplying a liquid dispersion of a structural substance including a target molecule into a well array such that the structural substance is introduced into wells of the well array, supplying a sealing solution into the well array such that a layer of the sealing solution is formed on the liquid dispersion in the wells, and that the liquid dispersion is sealed in the wells, extracting the target molecule from the structural substance, and detecting the target molecule.

公开(公告)号：US20190085385A1

公开(公告)日：2019-03-21

申请号：US16194612

申请日：2018-11-19

申请人： TOPPAN PRINTING CO., LTD.

发明人： Yoichi Makino ,  Takumi Hirase ,  Noriaki Arai ,  Hiroyuki Noji

IPC分类号： C12Q1/6858 ,  C12Q1/6825 ,  C12Q1/6855 ,  C12Q1/6876 ,  C12Q1/6818 ,  C12Q1/6827 ,  G01N21/64

摘要： A method of detecting a target molecule including binding, to first target molecules, specific binding substances which are capable of recognizing different epitopes and labeled with nucleic acid fragments, respectively, detecting the specific binding substances based on fluorescence signals of different fluorescence wavelengths from the nucleic acid fragments, and detecting the first target molecules based on the fluorescence signals that correspond to the specific binding substances, respectively.