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公开(公告)号：US20150191439A1
公开(公告)日：2015-07-09
申请号：US14363116
申请日：2012-12-06
发明人： Willaim F. DeGrado , Jizhou Wang , Jun Wang , Hyunil Jo , Belgin Canturk
IPC分类号： C07D271/06 , A61K31/417 , A61K45/06 , C07C215/50 , A61K31/137 , C07C257/18 , A61K31/155 , A61K31/15 , C07C251/24 , C07C211/38 , C07C271/28 , A61K31/27 , C07C255/58 , A61K31/26 , C07D257/04 , A61K31/41 , A61K31/4245 , C07D213/38 , A61K31/4402 , C07D233/88 , A61K31/505 , C07D261/08 , A61K31/5377 , C07D207/335
CPC分类号： C07D271/06 , A61K31/137 , A61K31/15 , A61K31/155 , A61K31/26 , A61K31/27 , A61K31/41 , A61K31/417 , A61K31/422 , A61K31/4245 , A61K31/4402 , A61K31/505 , A61K31/5377 , A61K45/06 , C07C211/27 , C07C211/38 , C07C211/49 , C07C215/50 , C07C217/58 , C07C219/28 , C07C233/43 , C07C235/20 , C07C237/30 , C07C255/24 , C07C255/58 , C07C271/28 , C07C317/32 , C07C323/32 , C07C2601/02 , C07C2603/74 , C07D207/335 , C07D213/38 , C07D233/88 , C07D257/04 , C07D261/08 , C07D413/04
摘要： Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia′) or (Ib), as described herein.
摘要翻译： 提供了本文所述的根据式（Ia）或（Ib）的化合物，其能够例如通过与M2跨膜蛋白的相互作用和其它类似的维生素C调节流感病毒（例如甲型流感病毒）的活性 。 还提供了用于治疗受甲型流感感染的疾病状态或感染的方法，其包括如本文所述施用包含根据式（Ia'）或（Ib）的一种或多种化合物的组合物。
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公开(公告)号：US09884832B2
公开(公告)日：2018-02-06
申请号：US14363116
申请日：2012-12-06
发明人： William F. DeGrado , Jizhou Wang , Jun Wang , Hyunil Jo , Belgin Canturk
IPC分类号： C07D413/04 , A61K31/422 , C07D271/06 , C07D207/335 , A61K31/417 , A61K45/06 , C07C215/50 , A61K31/137 , A61K31/155 , A61K31/15 , C07C211/38 , C07C271/28 , A61K31/27 , C07C255/58 , A61K31/26 , C07D257/04 , A61K31/41 , A61K31/4245 , C07D213/38 , A61K31/4402 , C07D233/88 , A61K31/505 , C07D261/08 , A61K31/5377 , C07C211/27 , C07C211/49 , C07C217/58 , C07C219/28 , C07C233/43 , C07C235/20 , C07C237/30 , C07C255/24 , C07C317/32 , C07C323/32
CPC分类号： C07D271/06 , A61K31/137 , A61K31/15 , A61K31/155 , A61K31/26 , A61K31/27 , A61K31/41 , A61K31/417 , A61K31/422 , A61K31/4245 , A61K31/4402 , A61K31/505 , A61K31/5377 , A61K45/06 , C07C211/27 , C07C211/38 , C07C211/49 , C07C215/50 , C07C217/58 , C07C219/28 , C07C233/43 , C07C235/20 , C07C237/30 , C07C255/24 , C07C255/58 , C07C271/28 , C07C317/32 , C07C323/32 , C07C2601/02 , C07C2603/74 , C07D207/335 , C07D213/38 , C07D233/88 , C07D257/04 , C07D261/08 , C07D413/04
摘要： Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia′) or (Ib), as described herein.
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