发明申请
- 专利标题： INHIBITORS TARGETING DRUG-RESISTANT INFLUENZA A
- 专利标题（中）： 抑制药物耐药性流感A
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申请号： US14363116申请日： 2012-12-06
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公开(公告)号： US20150191439A1公开(公告)日： 2015-07-09
- 发明人: Willaim F. DeGrado , Jizhou Wang , Jun Wang , Hyunil Jo , Belgin Canturk
- 申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 国际申请： PCT/US12/68163 WO 20121206
- 主分类号： C07D271/06
- IPC分类号： C07D271/06 ; A61K31/417 ; A61K45/06 ; C07C215/50 ; A61K31/137 ; C07C257/18 ; A61K31/155 ; A61K31/15 ; C07C251/24 ; C07C211/38 ; C07C271/28 ; A61K31/27 ; C07C255/58 ; A61K31/26 ; C07D257/04 ; A61K31/41 ; A61K31/4245 ; C07D213/38 ; A61K31/4402 ; C07D233/88 ; A61K31/505 ; C07D261/08 ; A61K31/5377 ; C07D207/335
摘要：
Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia′) or (Ib), as described herein.
公开/授权文献
- US09884832B2 Inhibitors targeting drug-resistant influenza A 公开/授权日：2018-02-06
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