公开(公告)号：US20240294962A1

公开(公告)日：2024-09-05

申请号：US18532609

申请日：2023-12-07

申请人： The Scripps Research Institute

发明人： Floyd E. ROMESBERG ,  Vivian T. DIEN ,  Aaron W. FELDMAN ,  Rebekah J. KARADEEMA ,  Lingjun LI ,  Michael P. LEDBETTER ,  Anne Xiaozhou ZHOU

IPC分类号： C12P19/34 ,  C07H19/24 ,  C07H21/04

CPC分类号： C12P19/34 ,  C07H19/24 ,  C07H21/04

摘要： Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

公开(公告)号：US20200318122A1

公开(公告)日：2020-10-08

申请号：US16913226

申请日：2020-06-26

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Floyd E. ROMESBERG ,  Michael P. LEDBETTER ,  Rebekah J. KARADEEMA

IPC分类号： C12N15/67 ,  C12N9/22 ,  C12N15/113 ,  C12P19/34

摘要： Disclosed herein are methods, cells, engineered microorganisms, and kits for increasing the production of polypeptides comprising one or more unnatural amino acids. Further provided are cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.