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公开(公告)号：US20190236784A1
公开(公告)日：2019-08-01
申请号：US16317741
申请日：2017-07-13
发明人： Ryoma BISE , Yoshitaka MAEDA , Masatoshi KURODA , Kazumasa YAMAKI , Ryohei TAKEUCHI , Fumiya OHASHI , Kouichirou YORI
CPC分类号： G06T7/0016 , C12M1/00 , C12M41/00 , C12M41/36 , G06K9/00127 , G06K9/00134 , G06K9/00147 , G06K9/4642 , G06T7/0012 , G06T7/20 , G06T2207/10016 , G06T2207/10056 , G06T2207/20072 , G06T2207/30024
摘要： [Problem] To evaluate objective cell groups by estimating a mixing ratio of objective cell group without affecting treatment itself and its production process when the objective cell groups include plural kinds of cell groups having different attributes, and to provide an image analysis system and a culture management system capable of accurately perform a quality control and a production control with low cost.[Solution] The cell quality evaluation system 1 detects a feature amount in each cell easily analyzable from images, and estimates a mixing ratio of each of plural kinds of cell groups included in the objective cell groups based on a distribution of the detected feature amount and pre-recorded information of the feature amount. As the feature amount, the embodiment uses a migration speed of each cell, easily distinguishable by analyzing tracking of each cell from plural images in time series.
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公开(公告)号：US20240358765A1
公开(公告)日：2024-10-31
申请号：US18767576
申请日：2024-07-09
CPC分类号： A61K35/34 , A61P1/16 , C12N5/0658 , C12N2502/28
摘要： A composition comprising skeletal myoblasts for treating liver dysfunction or improving liver function, in which the liver dysfunction can be hepatitis, liver fibrosis, liver cirrhosis, liver cancer, or liver failure. The composition can be used for promoting the proliferation of liver cells, regeneration of the liver tissue and/or angiogenesis, and providing a method for treating liver dysfunction, including a step of treating applying the composition to a site exhibiting liver dysfunction.
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公开(公告)号：US20220347345A1
公开(公告)日：2022-11-03
申请号：US17869392
申请日：2022-07-20
发明人： Yasuhiro MARUYA , Shun YAMAGUCHI , Kengo KANETAKA , Miki HIGASHI , Susumu EGUCHI , Fumiya OHASHI , Masaki MATSUMURA
摘要： A bioadhesive sheet-shaped material configured to be attached onto a surface of an organ, a method for producing the bioadhesive sheet-shaped material, and a method for treating a disease by using the bioadhesive sheet-shaped material. The bioadhesive sheet-shaped material includes an extracellular matrix layer, a sheet-shaped cell culture, and a biodegradable gel layer, where the sheet-shaped cell culture is interposed between the extracellular matrix layer and the biodegradable gel layer, and the bioadhesive sheet-shaped material is by attaching the extracellular matrix layer onto a surface of an organ.
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公开(公告)号：US20230347017A1
公开(公告)日：2023-11-02
申请号：US18216380
申请日：2023-06-29
发明人： Yasuhiro MARUYA , Shun YAMAGUCHI , Kengo KANETAKA , Susumu EGUCHI , Miki HIGASHI , Fumiya OHASHI , Miho KAI , Naoki ARAMAKI
摘要： A sheet-shaped cell culture for covering a cut surface of a pancreas, the cut surface of the pancreas includes cut surfaces of a pancreatic parenchyma and a pancreatic duct, and is connected to an intestinal wall of a small intestine in a liquid-tight manner via the sheet-shaped cell culture. A method for preventing or treating pancreatic fistula includes a step of covering, using a sheet-shaped cell culture, a cut surface of a pancreas that includes cut surfaces of a pancreatic parenchyma and a pancreatic duct, and a step of connecting the cut surface of the pancreas to an intestinal wall of a small intestine in a liquid-tight manner via the sheet-shaped cell culture.
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公开(公告)号：US20220275316A1
公开(公告)日：2022-09-01
申请号：US17682418
申请日：2022-02-28
发明人： Risa YUKI , Kenji OYAMA , Isamu MATSUDA , Fumiya OHASHI
摘要： A container is disclosed for isolating living cells. The container for crushing a sample by pressing includes a container main body having an opening part and a partition which separates an upper space and a lower space of the container main body, in which at least a part of the partition has a portion which is not horizontal with respect to the bottom of the container.
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公开(公告)号：US20210307890A1
公开(公告)日：2021-10-07
申请号：US17351295
申请日：2021-06-18
IPC分类号： A61F2/00
摘要： A device for efficiently attaching a sheet-shaped object to a target site includes a support body for supporting a sheet-shaped object, and a protective member having a low coefficient of friction for protecting one surface of the support, in which the support body supporting the sheet-shaped object is rolled while being protected by the protective member and can be inserted into a tubular body.
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公开(公告)号：US20180153155A1
公开(公告)日：2018-06-07
申请号：US15872157
申请日：2018-01-16
发明人： Fumiya OHASHI , Shigeru MIYAGAWA , Yoshiki SAWA , Shigeo MASUDA , Satsuki FUKUSHIMA , Atsuhiro SAITO
IPC分类号： A01N1/02 , G01N33/50 , C12N5/077 , A61K35/545
CPC分类号： A01N1/0215 , A01N1/0221 , A61K35/28 , A61K35/34 , A61K35/545 , C12N5/0653 , C12N5/0657 , C12N5/10 , G01N33/5073
摘要： A method is disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, the method maintaining the function of the cardiocytes derived from differentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, and yet reducing the possibility for tumorigenesis of undifferentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow. A method is also disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells (derived from adipose tissue or bone marrow, the method including dissociating cells from a cell population which has been induced to differentiate into cardiocytes from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow.
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公开(公告)号：US20230363377A1
公开(公告)日：2023-11-16
申请号：US18357486
申请日：2023-07-24
发明人： Isamu MATSUDA , Fumiya OHASHI
CPC分类号： A01N1/0273 , A01N1/021 , A61F2/0095
摘要： A transport container is configured to capture air bubbles remaining in a container with a simple mechanism and a simple operation to protect a graft. The transport container includes: a lid that seals a container for housing a graft, in which the lid has a protrusion protruding toward a space inside the container in a state of being attached to the container. A substantially annular groove is formed on a lower surface of the protrusion. Gas and liquid inside the container housing the graft and liquid are pushed out by the lid to achieve a liquid-tight state, and air bubbles in the liquid can be captured in the groove on the lower surface.
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9.发明公开公开(公告)号：US20230200377A1
公开(公告)日：2023-06-29
申请号：US18165446
申请日：2023-02-07
发明人： Fumiya OHASHI
IPC分类号： A01N1/02
CPC分类号： A01N1/0268 , A01N1/0284 , A01N1/0221
摘要： An object of the present invention is to provide a unit capable of efficiently and quickly detaching a graft from a device without causing damage or wrinkles. The above problem has been solved by a medical device that transfers a graft to a target site, the medical device including the graft and a support with the graft placed on one surface, in which the graft and the support are frozen in a state where the graft is placed, and the graft can be detached from the support and transferred to the target site by thawing the frozen graft placed on the support.
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公开(公告)号：US20220226388A1
公开(公告)日：2022-07-21
申请号：US17716269
申请日：2022-04-08
发明人： Fumiya OHASHI , Masaki MATSUMURA
摘要： Systems and methods of the present disclosure include a cell culture, a method for producing the cell culture, a kit for producing the cell culture, a method for treating inflammatory disease using the cell culture, and the like, for treating inflammatory disease. The cell culture containing cells can be derived from skeletal muscle.
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